Institution
University of Illinois at Chicago
Education•Chicago, Illinois, United States•
About: University of Illinois at Chicago is a education organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 57071 authors who have published 110536 publications receiving 4264936 citations.
Topics: Population, Poison control, Health care, Cancer, Medicine
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the validity of cross-sectional versus longitudinal surveys is compared using two data sets and a Monte Carlo simulation. And the authors provide a set of guidelines to assist researchers in deciding whether to employ a longitudinal survey approach.
Abstract: Marketing academics and practitioners frequently employ cross-sectional surveys. In recent years, editors, reviewers, and authors have expressed increasing concern about the validity of this approach. These validity concerns center on reducing common method variance bias and enhancing causal inferences. Longitudinal data collection is commonly offered as a solution to these problems. In this article, the authors conceptually examine the role of longitudinal surveys in addressing these validity concerns. Then, they provide an illustrative comparison of the validity of cross-sectional versus longitudinal surveys using two data sets and a Monte Carlo simulation. The conceptualization and findings suggest that under certain conditions, the results from cross-sectional data exhibit validity comparable to the results obtained from longitudinal data. This article concludes by offering a set of guidelines to assist researchers in deciding whether to employ a longitudinal survey approach.
748 citations
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TL;DR: The crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution is determined and it is found that the active site of memapin 2 is more open and less hydrophobic than that of other human aspartic proteases.
Abstract: Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity.
748 citations
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TL;DR: In this article, the effects of 13 material and operating parameters on electrospun fiber diameters are determined by varying the parameter values in an electrospinning theoretical model, and the results show that the five parameters (volumetric charge density, distance from nozzle to collector, initial jet/orifice radius, relaxation time, and viscosity) have the most significant effect on the jet radius.
747 citations
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TL;DR: It is shown that strain CP1200 produces a 17-residue peptide that induces cells of the Streptococcus pneumoniae species to develop competence and the hypothesis is presented that this transport protein is encoded by comA, previously shown to be required for elaboration of the pneumococcal competence activator.
Abstract: Competence for genetic transformation in Streptococcus pneumoniae has been known for three decades to arise in growing cultures at a critical cell density, in response to a secreted protease-sensitive signal. We show that strain CP1200 produces a 17-residue peptide that induces cells of the species to develop competence. The sequence of the peptide was found to be H-Glu-Met-Arg-Leu-Ser-Lys-Phe-Phe-Arg-Asp-Phe-Ile-Leu-Gln-Arg- Lys-Lys-OH. A synthetic peptide of the same sequence was shown to be biologically active in small quantities and to extend the range of conditions suitable for development of competence. Cognate codons in the pneumococcal chromosome indicate that the peptide is made ribosomally. As the gene encodes a prepeptide containing the Gly-Gly consensus processing site found in peptide bacteriocins, the peptide is likely to be exported by a specialized ATP-binding cassette transport protein as is characteristic of these bacteriocins. The hypothesis is presented that this transport protein is encoded by comA, previously shown to be required for elaboration of the pneumococcal competence activator.
746 citations
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TL;DR: In all of the brain areas studied, RELN and its mRNA were significantly reduced in patients with schizophrenia; this decrease was similar in patients affected by undifferentiated or paranoid schizophrenia and is interpreted within a neurodevelopmental/vulnerability "two-hit" model for the etiology of schizophrenia.
Abstract: Postmortem prefrontal cortices (PFC) (Brodmann’s areas 10 and 46), temporal cortices (Brodmann’s area 22), hippocampi, caudate nuclei, and cerebella of schizophrenia patients and their matched nonpsychiatric subjects were compared for reelin (RELN) mRNA and reelin (RELN) protein content. In all of the brain areas studied, RELN and its mRNA were significantly reduced (≈50%) in patients with schizophrenia; this decrease was similar in patients affected by undifferentiated or paranoid schizophrenia. To exclude possible artifacts caused by postmortem mRNA degradation, we measured the mRNAs in the same PFC extracts from γ-aminobutyric acid (GABA)A receptors α1 and α5 and nicotinic acetylcholine receptor α7 subunits. Whereas the expression of the α7 nicotinic acetylcholine receptor subunit was normal, that of the α1 and α5 receptor subunits of GABAA was increased when schizophrenia was present. RELN mRNA was preferentially expressed in GABAergic interneurons of PFC, temporal cortex, hippocampus, and glutamatergic granule cells of cerebellum. A protein putatively functioning as an intracellular target for the signal-transduction cascade triggered by RELN protein released into the extracellular matrix is termed mouse disabled-1 (DAB1) and is expressed at comparable levels in the neuroplasm of the PFC and hippocampal pyramidal neurons, cerebellar Purkinje neurons of schizophrenia patients, and nonpsychiatric subjects; these three types of neurons do not express RELN protein. In the same samples of temporal cortex, we found a decrease in RELN protein of ≈50% but no changes in DAB1 protein expression. We also observed a large (up to 70%) decrease of GAD67 but only a small decrease of GAD65 protein content. These findings are interpreted within a neurodevelopmental/vulnerability “two-hit” model for the etiology of schizophrenia.
744 citations
Authors
Showing all 57433 results
Name | H-index | Papers | Citations |
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Meir J. Stampfer | 277 | 1414 | 283776 |
Frank B. Hu | 250 | 1675 | 253464 |
Lewis C. Cantley | 196 | 748 | 169037 |
Ronald Klein | 194 | 1305 | 149140 |
Anil K. Jain | 183 | 1016 | 192151 |
Yusuke Nakamura | 179 | 2076 | 160313 |
Bruce M. Spiegelman | 179 | 434 | 158009 |
Jie Zhang | 178 | 4857 | 221720 |
D. M. Strom | 176 | 3167 | 194314 |
Yury Gogotsi | 171 | 956 | 144520 |
Todd R. Golub | 164 | 422 | 201457 |
Rodney S. Ruoff | 164 | 666 | 194902 |
Philip A. Wolf | 163 | 459 | 114951 |
Barbara E.K. Klein | 160 | 856 | 93319 |
David Jonathan Hofman | 159 | 1407 | 140442 |