University of Illinois at Chicago

About: University of Illinois at Chicago is a education organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 57071 authors who have published 110536 publications receiving 4264936 citations.

Joint Estimation of Model Parameters and Outlier Effects in Time Series

Abstract: Time series data are often subject to uncontrolled or unexpected interventions, from which various types of outlying observations are produced. Outliers in time series, depending on their nature, may have a moderate to significant impact on the effectiveness of the Standard methodology for time series analysis with respect to model identification, estimation, and forecasting. In this article we use an iterative outlier detection and adjustment procedure to obtain joint estimates of model parameters and outlier effects. Four types of outliers are considered, and the issues of spurious and masking effects are discussed. The major differences between this procedure and those proposed in earlier literature include (a) the types and effects of outliers are obtained based on less contaminated estimates of model parameters, (b) the outlier effects are estimated simultaneously using multiple regression, and (c) the model parameters and the outlier effects are estimated jointly. The sampling behavior of the test s...

The Rise of Anti-foreigner Sentiment in European Societies, 1988-2000

Abstract: The study examines change over time in sentiments toward out-group populations in European societies. For this purpose data were compiled from four waves of the Eurobarometer surveys for 12 countries that provided detailed and comparable information on attitudes toward foreigners between 1988 and 2000. A series of multilevel hierarchical linear models were estimated to examine change in the effects of individual- and country-level sources of threat on anti-foreigner sentiment. The analysis shows a substantial rise in antiforeigner sentiment between 1988 and 2000 in all 12 countries. The rise in anti-foreigner sentiment was steep in the early period (between 1988 and 1994), then leveled off after that. Although anti-foreigner sentiment tends to be more pronounced in places with a large proportion of foreign populations and where economic conditions are less prosperous, the effects of both factors on anti-foreigner sentiment have not changed over time. The analysis also shows that anti-foreigner sentiment i...

Synonymous codon usage in Drosophila melanogaster: natural selection and translational accuracy.

Abstract: I present evidence that natural selection biases synonymous codon usage to enhance the accuracy of protein synthesis in Drosophila melanogaster. Since the fitness cost of a translational misincorporation will depend on how the amino acid substitution affects protein function, selection for translational accuracy predicts an association between codon usage in DNA and functional constraint at the protein level. The frequency of preferred codons is significantly higher at codons conserved for amino acids than at nonconserved codons in 38 genes compared between D. melanogaster and Drosophila virilis or Drosophila pseudoobscura (Z = 5.93, P

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Abstract: In recent years there has been a growing interest among cancer biologists in cancer metabolism. This Review summarizes past and recent advances in our understanding of the reprogramming of glucose metabolism in cancer cells, which is mediated by oncogenic drivers and by the undifferentiated character of cancer cells. The reprogrammed glucose metabolism in cancer cells is required to fulfil anabolic demands. This Review discusses the possibility of exploiting the reprogrammed glucose metabolism for therapeutic approaches that selectively target cancer cells.