Institution
University of Illinois at Chicago
Education•Chicago, Illinois, United States•
About: University of Illinois at Chicago is a education organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 57071 authors who have published 110536 publications receiving 4264936 citations.
Topics: Population, Poison control, Health care, Cancer, Medicine
Papers published on a yearly basis
Papers
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TL;DR: In this paper, it was shown that it is the overproduction of Sup35 protein, and not the excess of SUP35 DNA or mRNA, that causes the appearance of non-Mendelian factors.
Abstract: We have previously shown that multicopy plasmids containing the complete SUP35 gene are able to induce the appearance of the non-Mendelian factor [ PSI ]. This result was later interpreted by others as a crucial piece of evidence for a model postulating that [ PSI ] is a self-modified, prion-like conformational derivative of the Sup35 protein. Here we support this interpretation by proving that it is the overproduction of Sup35 protein, and not the excess of SUP35 DNA or mRNA that causes the appearance of [ PSI ]. We also show that the “prion-inducing domain” of Sup35p is in the N-terminal region, which, like the “prion-inducing domain” of another yeast prion, Ure2p, was previously shown to be distinct from the functional domain of the protein. This suggests that such a chimeric organization may be a common pattern of some prion elements. Finally, we find that [ PSI ] factors of different efficiencies and different mitotic stabilities are induced in the same yeast strain by overproduction of the identical Sup35 protein. We suggest that the different [ PSI ]-containing derivatives are analogous to the mysterious mammalian prion strains and result from different conformational variants of Sup35p.
522 citations
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TL;DR: The prevalence of fecal incontinence appears to be more common than previously appreciated and it would seem important to more actively pursue this "silent affliction" particularly in patients who do not readily volunteer this information.
522 citations
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National Institutes of Health1, University of Utah2, Baystate Medical Center3, Georgetown University4, University of Illinois at Chicago5, Maimonides Medical Center6, University of Texas Health Science Center at Houston7, MetroHealth8, Christiana Care Health System9, Cedars-Sinai Medical Center10, University of Miami11, Indiana University12, Summa Health System13
TL;DR: To decrease cesarean delivery rate in the United States, reducing primary ces Harean delivery is the key, particularly in nulliparous women and in induced labor.
522 citations
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TL;DR: Lacunarity analysis is broadly applicable to many data sets used in the natural sciences; it is illustrated its application to both geological and ecological data.
Abstract: Lacunarity analysis is a multiscaled method for describing patterns of spatial dispersion. It can be used with both binary and quantitative data in one, two, and three dimensions. Although originally developed for fractal objects, the method is more general and can be readily used to describe nonfractal and multifractal patterns. Lacunarity analysis is broadly applicable to many data sets used in the natural sciences; we illustrate its application to both geological and ecological data. {copyright} {ital 1996 The American Physical Society.}
522 citations
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TL;DR: The modENCODE cis-regulatory annotation project as discussed by the authors has identified more than 20,000 candidate regulatory elements and validated a subset of predictions for promoters, enhancers and insulators in vivo.
Abstract: Systematic annotation of gene regulatory elements is a major challenge in genome science. Direct mapping of chromatin modification marks and transcriptional factor binding sites genome-wide has successfully identified specific subtypes of regulatory elements. In Drosophila several pioneering studies have provided genome-wide identification of Polycomb response elements, chromatin states, transcription factor binding sites, RNA polymerase II regulation and insulator elements; however, comprehensive annotation of the regulatory genome remains a significant challenge. Here we describe results from the modENCODE cis-regulatory annotation project. We produced a map of the Drosophila melanogaster regulatory genome on the basis of more than 300 chromatin immunoprecipitation data sets for eight chromatin features, five histone deacetylases and thirty-eight site-specific transcription factors at different stages of development. Using these data we inferred more than 20,000 candidate regulatory elements and validated a subset of predictions for promoters, enhancers and insulators in vivo. We identified also nearly 2,000 genomic regions of dense transcription factor binding associated with chromatin activity and accessibility. We discovered hundreds of new transcription factor co-binding relationships and defined a transcription factor network with over 800 potential regulatory relationships.
522 citations
Authors
Showing all 57433 results
Name | H-index | Papers | Citations |
---|---|---|---|
Meir J. Stampfer | 277 | 1414 | 283776 |
Frank B. Hu | 250 | 1675 | 253464 |
Lewis C. Cantley | 196 | 748 | 169037 |
Ronald Klein | 194 | 1305 | 149140 |
Anil K. Jain | 183 | 1016 | 192151 |
Yusuke Nakamura | 179 | 2076 | 160313 |
Bruce M. Spiegelman | 179 | 434 | 158009 |
Jie Zhang | 178 | 4857 | 221720 |
D. M. Strom | 176 | 3167 | 194314 |
Yury Gogotsi | 171 | 956 | 144520 |
Todd R. Golub | 164 | 422 | 201457 |
Rodney S. Ruoff | 164 | 666 | 194902 |
Philip A. Wolf | 163 | 459 | 114951 |
Barbara E.K. Klein | 160 | 856 | 93319 |
David Jonathan Hofman | 159 | 1407 | 140442 |