University of Illinois at Chicago

About: University of Illinois at Chicago is a education organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 57071 authors who have published 110536 publications receiving 4264936 citations.

A longitudinal study on the early development of leader-member exchanges.

Abstract: The authors investigated the first 6 months that 166 newly hired employees and their immediate supervisors worked together. Expectations, perceived similarity, liking, demographic similarity, and performance were examined as determinants of leader-member exchanges (LMXs). Leader and member expectations of each other assessed in the first 5 days in the life of the dyad predicted LMXs at 2 weeks and at 6 weeks following the 1st day of the dyads' existence. Member expectations of leaders also predicted LMXs at 6 months. Following nearly the same pattern, perceived similarity and liking from both the leaders'and members' perspectives predicted LMXs at most time periods. Demographic similarity between leaders and members had no significant effects on LMX development, and subordinate performance ratings were relatively less important in predicting LMX than were affective variables

The 2.0 Å crystal structure of a heterotrimeric G protein

Abstract: The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates their interaction with receptor and effector molecules. The interaction involves two distinct interfaces and dramatically alters the conformation of the alpha but not of the beta gamma subunits. The location of the known sites for post-translational modification and receptor coupling suggest a plausible orientation with respect to the membrane surface and an activated heptahelical receptor.

Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan.

Abstract: Objective The National Health Insurance Research Database (NHIRD) is commonly used for pharmacoepidemiological research in Taiwan. This study evaluated the validity of the database for patients with a principal diagnosis of ischemic stroke. Study design and methods This cross-sectional study compares records in the NHIRD with those in one medical center. Patients hospitalized for ischemic stroke in 1999 were identified from both databases. The discharge notes, laboratory data, and medication orders during admission and the first discharge visit were reviewed to validate ischemic stroke diagnoses and aspirin prescribing in the NHIRD. Agreement between the two databases in comorbidities of ischemic stroke diagnosis was evaluated using ICD-9 codes. Results Three hundred and seventy two cases were identified from the NHIRD; among them, 364 cases (97.85%) were confirmed as ischemic stroke by radiology examination and clinical presentation. Among these confirmed cases, 344 (94.51%) were assigned ‘ischemic stroke’ as the principal diagnosis in the NHIRD. The overall agreement of comorbid diagnoses between the databases was 48.39%. The PPV for selected conditions also varied widely, from 0.50 for fracture to 1.00 for colon cancer. The accuracy of recorded aspirin prescriptions was higher in first post-discharge visits (PPV = 0.94) than during hospitalization (PPV = 0.88). Conclusion The accuracy of the NHIRD in recording ischemic stroke diagnoses and aspirin prescriptions was high, and the NHIRD appears to be a valid resource for population research in ischemic stroke. Copyright © 2010 John Wiley & Sons, Ltd.