University of Illinois at Chicago

About: University of Illinois at Chicago is a education organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 57071 authors who have published 110536 publications receiving 4264936 citations.

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.

Abstract: The 2.2 A crystal structure of activated rod transducin, Gtα-GTPγS, shows the bound GTPγS molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data.

Heterogeneous Information Network Embedding for Recommendation

Abstract: Due to the flexibility in modelling data heterogeneity, heterogeneous information network (HIN) has been adopted to characterize complex and heterogeneous auxiliary data in recommender systems, called HIN based recommendation . It is challenging to develop effective methods for HIN based recommendation in both extraction and exploitation of the information from HINs. Most of HIN based recommendation methods rely on path based similarity, which cannot fully mine latent structure features of users and items. In this paper, we propose a novel heterogeneous network embedding based approach for HIN based recommendation, called HERec. To embed HINs, we design a meta-path based random walk strategy to generate meaningful node sequences for network embedding. The learned node embeddings are first transformed by a set of fusion functions, and subsequently integrated into an extended matrix factorization (MF) model. The extended MF model together with fusion functions are jointly optimized for the rating prediction task. Extensive experiments on three real-world datasets demonstrate the effectiveness of the HERec model. Moreover, we show the capability of the HERec model for the cold-start problem, and reveal that the transformed embedding information from HINs can improve the recommendation performance.

Validity in Interpretation

Abstract: By demonstrating the uniformity and universality of the principles of valid interpretation of verbal texts of any sort, this closely reasoned examination provides a theoretical foundation for a discipline that is fundamental to virtually all humanistic studies. It defines the grounds on which textual interpretation can claim to establish objective knowledge, defends that claim against such skeptical attitudes as historicism and psychologism, and shows that many confusions can be avoided if the distinctions between meaning and significance, interpretation and criticism are correctly understood. It provides perhaps the first genuinely comprehensive account of hermeneutic theory to appear in English and the first systematic presentation of the principles of valid interpretation in any language.Mr. Hirsch, associate professor of English at the University of Virginia, is the author of Wordsworth and Schelling and Innocence and Experience: An Introduction to Blake. "Here is a book that brings logic to the most unruly of disciplines, literary interpretation. Viewing this subject within the tradition of hermeneutics, Mr. Hirsch is able to trace its origins and development with brilliant insight. The result is a lucidly systemic and authoritative account of the premises and procedures applicable to the interpretation of a literary text. Mr. Hirsch has performed a monumental service thereby that of reinstating the credentials of objectivism and defining the limits of the aesthetics of truth. This study is a necessary took for anyone who wants to talk sense about literature."-Virginia Quarterly Review "Professor Hirsch demonstrates convincingly that objectivity is attainable in humane studies, and that it is not identified with the subject but with the evidence. A valid interpretation is not necessarily a correct one, but one which is more probably than any other on the basis of existing evidence. He makes a subtle and important distinction between a text's 'meaning' (which does not change) and its 'significance' (which does), and brilliantly relates meaning to understanding (the necessary preliminary to interpretation) and interpretation to explanation..." In short, this is a work which future students of literary theory cannot afford to neglect."-Notes and Queries E.D. Hirsch, Jr., is professor of English at the University of Virginia.