Showing papers by "University of Massachusetts Boston published in 2009"

Breast cancer after use of estrogen plus progestin in postmenopausal women

Abstract: We analyzed the results of the WHI randomized clinical trial — in which one study group received 0.625 mg of conjugated equine estrogens plus 2.5 mg of medroxyprogesterone acetate daily and another group received placebo — and examined temporal trends in breast-cancer diagnoses in the WHI observational-study cohort. Risk factors for breast cancer, frequency of mammography, and time-specific incidence of breast cancer were assessed in relation to combined hormone use. Results In the clinical trial, there were fewer breast-cancer diagnoses in the group receiving estrogen plus progestin than in the placebo group in the initial 2 years of the study, but the number of diagnoses increased over the course of the 5.6-year intervention period. The elevated risk decreased rapidly after both groups stopped taking the study pills, despite a similar frequency of mammography. In the observational study, the incidence of breast cancer was initially about two times as high in the group receiving menopausal hormones as in the placebo group, but this difference in incidence decreased rapidly in about 2 years, coinciding with year-to-year reductions in combined hormone use. During this period, differences in the frequency of mammography between the two groups were unchanged. Conclusions The increased risk of breast cancer associated with the use of estrogen plus progestin declined markedly soon after discontinuation of combined hormone therapy and was unrelated to changes in frequency of mammography.

Clinical Assessment and Management of Toddlers With Suspected Autism Spectrum Disorder: Insights From Studies of High-Risk Infants

Abstract: With increased public awareness of the early signs and recent American Academy of Pediatrics recommendations that all 18- and 24-month-olds be screened for autism spectrum disorders, there is an increasing need for diagnostic assessment of very young children. However, unique challenges exist in applying current diagnostic guidelines for autism spectrum disorders to children under the age of 2 years. In this article, we address challenges related to early detection, diagnosis, and treatment of autism spectrum disorders in this age group. We provide a comprehensive review of findings from recent studies on the early development of children with autism spectrum disorders, summarizing current knowledge on early signs of autism spectrum disorders, the screening properties of early detection tools, and current best practice for diagnostic assessment of autism spectrum disorders before 2 years of age. We also outline principles of effective intervention for children under the age of 2 with suspected/confirmed autism spectrum disorders. It is hoped that ongoing studies will provide an even stronger foundation for evidence-based diagnostic and intervention approaches for this critically important age group.

Influence of Arabidopsis thaliana accessions on rhizobacterial communities and natural variation in root exudates

Abstract: Plant species is considered to be one of the most important factors in shaping rhizobacterial communities, but specific plant-microbe interactions in the rhizosphere are still not fully understood. Arabidopsis thaliana, for which a large number of naturally occurring ecotype accessions exist, lacks mycorrhizal associations and is hence an ideal model for rhizobacterial studies. Eight Arabidopsis accessions were found to exert a marked selective influence on bacteria associated with their roots, as determined by terminal-restriction fragment length polymorphism (T-RFLP) and ribosomal intergenic spacer analysis (RISA). Community differences in species composition and relative abundance were both significant (P <0.001). The eight distinct and reproducible accession-dependent community profiles also differed from control bulk soil. Root exudates of these variants were analysed by high performance liquid chromatography (HPLC) to try to establish whether the unique rhizobacterial assemblages among accessions could be attributed to plant-regulated chemical changes in the rhizosphere. Natural variation in root exudation patterns was clearly exhibited, suggesting that differences in exudation patterns among accessions could be influencing bacterial assemblages. Other factors such as root system architecture are also probably involved. Finally, to investigate the Arabidopsis rhizosphere further, the phylogenetic diversity of rhizobacteria from accession Cvi-0 is described.

Infants of Depressed Mothers

Abstract: Depression is the most frequent psychiatric disorder and has long-term, compromising effects on the mother-infant relationship and the child's development. The infant continuously faces a climate of negative affect that disrupts the interactive experience of the infant and the mother. This article presents findings on the impact of maternal depression on the infant affective state and the specific interactive patterns associated with infant affect regulation. Mother-infant interactions were studied using microanalytic, second-by-second methods in the laboratory and also by using naturalistic home observations. The empirical findings highlight the impact of maternal depression on the infant affective state and on the capacity for repairing states of miscoordination. The impact is seen not only in severely and acutely depressed mothers, but in mothers who have only high levels of depressive symptoms. These infants develop negative affective states that bias their interactions with others and exacerbate their affective problems. Further findings with regard to gender-specific effects show that male infants are more vulnerable than female infants to maternal depression. The findings point out the need for therapeutic interventions that focus on the mother-infant dyad and infant affective state in the treatment of maternal depression.

An artificial neural network to estimate physical activity energy expenditure and identify physical activity type from an accelerometer.

Abstract: The aim of this investigation was to develop and test two artificial neural networks (ANN) to apply to physical activity data collected with a commonly used uniaxial accelerometer. The first ANN model estimated physical activity metabolic equivalents (METs), and the second ANN identified activity type. Subjects (n = 24 men and 24 women, mean age = 35 yr) completed a menu of activities that included sedentary, light, moderate, and vigorous intensities, and each activity was performed for 10 min. There were three different activity menus, and 20 participants completed each menu. Oxygen consumption (in ml x kg(-1) x min(-1)) was measured continuously, and the average of minutes 4-9 was used to represent the oxygen cost of each activity. To calculate METs, activity oxygen consumption was divided by 3.5 ml x kg(-1) x min(-1) (1 MET). Accelerometer data were collected second by second using the Actigraph model 7164. For the analysis, we used the distribution of counts (10th, 25th, 50th, 75th, and 90th percentiles of a minute's second-by-second counts) and temporal dynamics of counts (lag, one autocorrelation) as the accelerometer feature inputs to the ANN. To examine model performance, we used the leave-one-out cross-validation technique. The ANN prediction of METs root-mean-squared error was 1.22 METs (confidence interval: 1.14-1.30). For the prediction of activity type, the ANN correctly classified activity type 88.8% of the time (confidence interval: 86.4-91.2%). Activity types were low-level activities, locomotion, vigorous sports, and household activities/other activities. This novel approach of applying ANNs for processing Actigraph accelerometer data is promising and shows that we can successfully estimate activity METs and identify activity type using ANN analytic procedures.

Sensory Over-Responsivity in Elementary School: Prevalence and Social-Emotional Correlates

Abstract: Sensory over-responsivity (SOR) towards tactile and auditory input can impact children's participation in academic and social activities; however the prevalence of SOR behaviors and their relation to social-emotional problems and competence has not been rigorously studied. This study investigated SOR in a representative sample of elementary school-aged children (n=925, 50% boys, ages 7-11 years) who were followed from infancy. Sixteen percent of parents reported that at least four tactile or auditory sensations bothered their children. Being bothered by certain sensations was common while others were relatively rare. Parents of children with versus without elevated SOR in school-age reported higher frequencies of early and co-occurring internalizing, externalizing, and dysregulation problems, and lower levels of concurrent adaptive social behaviors. Early identification of elevated SOR and assessment of concurrent social-emotional status are important to minimize their impact on social adaptive behaviors at school age.

The leadership of emergence: A complex systems leadership theory of emergence at successive organizational levels☆

Abstract: Complexity science reframes leadership by focusing on the dynamic interactions between all individuals, explaining how those interactions can, under certain conditions, produce emergent outcomes. We develop a Leadership of Emergence using this approach, through an analysis of three empirical studies which document emergence in distinct contexts. Each of these studies identifies the same four “conditions” for emergence: the presence of a Dis-equilibrium state, Amplifying actions, Recombination/“Self-organization”, and Stabilizing feedback. From these studies we also show how these conditions can be generated through nine specific behaviors which leaders can enact, including: Disrupt existing patterns through embracing uncertainty and creating controversy, Encourage novelty by allowing experiments and supporting collective action, Provide sensemaking and sensegiving through the artful use of language and symbols, and Stabilize the system by Integrating local constraints. Finally, we suggest ways for advancing a meso-model of leadership, and show how our findings can improve complexity science applications in management.

Anger, Stress Proliferation, and Depressed Mood Among Parents of Children with ASD: A Longitudinal Replication

Abstract: Stress proliferation (the tendency for stressors to create additional stressors) has been suggested as an important contributor to depression among caregivers. The present study utilized longitudinal data from 90 parents of children with ASD to replicate and extend a prior cross-sectional study on stress proliferation by Benson (J Autism Develop Disord 36:685-695, 2006). Consistent with Benson's earlier findings, regression analyses indicated that stress proliferation mediated the effect of child symptom severity on parent depression. Parent anger was also found to mediate the effect of symptom severity on stress proliferation as well as the effect of stress proliferation on parent depression. Finally, informal social support was found to be related to decreased parent depressed mood over time. Implications of study findings are discussed.

Toward an Intercultural Perspective of Racial and Ethnic Minority College Student Persistence

Abstract: Six of every 10 Black and Latina/o undergraduates who begin higher education at a four-year institution will fail to earn a bachelor’s degree within six years. These low rates of attainment are accompanied by negative consequences for individual students and the larger society. Consequently, scholars have advocated for the importance of considering new perspectives of minority college student persistence in higher education research. This study is aimed at generating a new intercultural framework for understanding racial/ethnic minority student persistence processes using existing literature and the voices of students of color. Implications for future research and practice are discussed.

A framework for adapting agile development methodologies

Abstract: Agile development methodologies such as Extreme Programming are becoming increasingly popular due to their focus on managing time to market constraints and the ability to accommodate changes during the software development life cycle. However, such methodologies need to be adapted to suit the needs of different contexts. Past literature has paid little attention to examine the adaptation of agile methodologies. Using adaptive structuration theory as a lens to analyze data from a multisite case study, we examine how the structure of agile methods, projects, and organizations affect the adaptation of agile methodologies. We describe the various sources of structure that affect appropriation of agile practices, the set of appropriated practices and their characteristics, and their link to process outcomes. Based on our findings, we provide prescriptions for adapting agile development methodologies. We also discuss how adapted agile practices can address several challenges faced by agile development teams.

Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia

Abstract: Oscillatory electroencephalogram (EEG) abnormalities may reflect neural circuit dysfunction in neuropsychiatric disorders. Previously we have found positive correlations between the phase synchronization of beta and gamma oscillations and hallucination symptoms in schizophrenia patients. These findings suggest that the propensity for hallucinations is associated with an increased tendency for neural circuits in sensory cortex to enter states of oscillatory synchrony. Here we tested this hypothesis by examining whether the 40 Hz auditory steady-state response (ASSR) generated in the left primary auditory cortex is positively correlated with auditory hallucination symptoms in schizophrenia. We also examined whether the 40 Hz ASSR deficit in schizophrenia was associated with cross-frequency interactions. Sixteen healthy control subjects (HC) and 18 chronic schizophrenia patients (SZ) listened to 40 Hz binaural click trains. The EEG was recorded from 60 electrodes and average-referenced offline. A 5-dipole model was fit from the HC grand average ASSR, with 2 pairs of superior temporal dipoles and a deep midline dipole. Time-frequency decomposition was performed on the scalp EEG and source data. Phase locking factor (PLF) and evoked power were reduced in SZ at fronto-central electrodes, replicating prior findings. PLF was reduced in SZ for non-homologous right and left hemisphere sources. Left hemisphere source PLF in SZ was positively correlated with auditory hallucination symptoms, and was modulated by delta phase. Furthermore, the correlations between source evoked power and PLF found in HC was reduced in SZ for the LH sources. These findings suggest that differential neural circuit abnormalities may be present in the left and right auditory cortices in schizophrenia. In addition, they provide further support for the hypothesis that hallucinations are related to cortical hyperexcitability, which is manifested by an increased propensity for high-frequency synchronization in modality-specific cortical areas.

Plant age and genotype impact the progression of bacterial community succession in the Arabidopsis rhizosphere.

Abstract: The rhizosphere is strongly influenced by plant-derived phytochemicals exuded by roots and plant species exert a major selective force for bacteria colonizing the root-soil interface. We have previously shown that rhizobacterial recruitment is tightly regulated by plant genetics, by showing that natural variants of Arabidopsis thaliana support genotype-specific rhizobacterial communities while also releasing a unique blend of exudates at six weeks post-germination. To further understand how exudate release is controlled by plants, changes in rhizobacterial assemblages of two Arabidopsis accessions, Cvi and Ler where monitored throughout the plants' life cycle. Denaturing gradient gel electrophoresis (DGGE) fingerprints revealed that bacterial communities respond to plant derived factors immediately upon germination in an accession-specific manner. Rhizobacterial succession progresses differently in the two accessions in a reproducible manner. However, as plants age, rhizobacterial and control bulk soil communities converge, indicative of an attenuated rhizosphere effect, which coincides with the expected slow down in the active release of root exudates as plants reach the end of their life cycle. These data strongly suggest that exudation changes during plant development are highly genotype-specific, possibly reflecting the unique, local co-evolutionary communication processes that developed between Arabidopsis accessions and their indigenous microbiota.

Deconstructing the model minority myth and how it contributes to the invisible minority reality in higher education research

Abstract: A better understanding of the model minority myth of Asian American and Pacific Islanders can help move toward generating an authentic understanding of these students.

The impact of agricultural intensification and irrigation on land-atmosphere interactions and Indian monsoon precipitation — A mesoscale modeling perspective

Abstract: article i nfo Article history: Accepted 8 February 2008 Available online xxxx Using the Regional Atmospheric Modeling System (RAMS) we show that agricultural intensification and irrigation can modify the surface moisture and energy distribution, which alters the boundary layer and regional convergence, mesoscale convection, and precipitation patterns over the Indian monsoon region. Four experiments were conducted to simulate a rain event from 16 to 20 July 2002 over the Indian region: (i) a control with Global Land Cover land use and observed Normalized Difference Vegetation Index, (ii) an irrigated crop scenario, (iii) a non-irrigated crop scenario, and (iv) a scenario for potential (natural) vegetation. Results indicate that even under active monsoon conditions, the simulated surface energy and moisture flux over the Indian monsoon region are sensitive to the irrigation intensity and this effect is more pronounced than the impact of land use change from the potential vegetation to the agricultural landscape. When model outputs were averaged over the south Asia model domain, a statistically significant decrease in mean sensible heat flux between the potential vegetation and the irrigated agriculture scenarios of 11.7 Wm −2

Climate Change and the Emergence of New Organizational Landscapes

Abstract: There is general agreement across the world that human-made climate change is a serious global problem, although there are still some sceptics who challenge this view. Research in organization studies on the topic is relatively new. Much of this research, however, is instrumental and managerialist in its focus on ‘win-win’ opportunities for business or its treatment of climate change as just another corporate social responsibility (CSR) exercise. In this paper, we suggest that climate change is not just an environmental problem requiring technical and managerial solutions; it is a political issue where a variety of organizations – state agencies, firms, industry associations, NGOs and multilateral organizations – engage in contestation as well as collaboration over the issue. We discuss the strategic, institutional and political economy dimensions of climate change and develop a socioeconomic regimes approach as a synthesis of these different theoretical perspectives. Given the urgency of the problem and ...

Fluorous linker-facilitated chemical synthesis.

Abstract: 2.2.6. Tetrahydropyran (THP)-Type Linkers 763 2.2.7. Carbonyl Linkers 764 2.2.8. Phenol Linkers 765 2.2.9. Benzaldehyde Linkers for Diol Protections 766 2.3. Carboxyl Group Protections 768 2.3.1. Trimetylsilylethyl (TMSE)-Type Linkers 768 2.3.2. Benzhydryl (Rink)-Type Linkers 768 2.3.3. PMB-OH-Type Linkers 768 2.3.4. t-Butyl-Type Linkers 770 2.4. Diol Linkers for Carbonyl Group Protections 770 3. Synthetic Applications of Fluorous Displaceable Linkers 772

Catalytic pyrolysis of solid biomass and related biofuels, aromatic, and olefin compounds

Abstract: This invention relates to compositions and methods for fluid hydrocarbon product, and more specifically, to compositions and methods for fluid hydrocarbon product via catalytic pyrolysis. Some embodiments relate to methods for the production of specific aromatic products (e.g., benzene, toluene, naphthalene, xylene, etc.) via catalytic pyrolysis. Some such methods may involve the use of a composition comprising a mixture of a solid hydrocarbonaceous material and a heterogeneous pyrolytic catalyst component. In some embodiments, the mixture may be pyrolyzed at high temperatures (e.g., between 500 °C and 1000 °C). The pyrolysis may be conducted for an amount of time at least partially sufficient for production of discrete, identifiable biofuel compounds. Some embodiments involve heating the mixture of catalyst and hydrocarbonaceous material at high rates (e.g., from about 50 °C per second to about 1000 0C per second). The methods described herein may also involve the use of specialized catalysts. For example, in some cases, zeolite catalysts may be used; optionally, the catalysts used herein may have high silica to alumina molar ratios. In some instances, the composition fed to the pyrolysis reactor may have a relatively high catalyst to hydrocarbonaceous material mass ratio (e.g., from about 5: 1 to about 20:1).

Consumers’ Willingness to Pay for Organic Products: A Case From Kathmandu Valley

Abstract: This paper presents the consumers' willingness to pay a price premium for organic products in Kathmandu Valley. The Nepal Permaculture Group surveyed 180 consumers using semi-structured questionnaires to examine peoples' perception about organic products and assess their willingness to pay for such products. The study revealed that all respondents are willing to pay price premium, but the level of acceptability varied considerably. A total of 58% of the consumers are willing to pay 6- 20% price premium, whereas 13% are willing to pay up to 50% premium. The average premium was estimated about 30%. About 39% of the respondents feel the extra cost for organic products is reasonable, while 27% considered it too high. The survey also suggested that the consumption of organic products is increasing; however, product development and innovations in certification, processing, labeling and packaging are needed to further stimulate demand. Key words: Certification; Consumer perception; Organic products; Price premium; Processing; Willingness to pay The Journal of Agriculture and Environment Vol:10, Jun.2009 Page: 15-26

Involvement of adult siblings of persons with developmental disabilities in future planning.

Abstract: This study examined factors influencing involvement of siblings of individuals with developmental disabilities in future planning and their expectation of future caregiving. The sample con...

Closing the Gap: Addressing the Vocabulary Needs of English-Language Learners in Bilingual and Mainstream Classrooms:

Abstract: Gaps in reading performance between Anglo and Latino children are associated with gaps in vocabulary knowledge. An intervention was designed to enhance fifth graders' academic vocabulary. The meanings of academically useful words were taught together with strategies for using information from context, from morphology, from knowledge about multiple meanings, and from cognates to infer word meaning. Among the principles underlying the intervention were that new words should be encountered in meaningful text, that native Spanish speakers should have access to the text's meaning through Spanish, that words should be encountered in varying contexts, and that word knowledge involves spelling, pronunciation, morphology, and syntax as well as depth of meaning. Fifth graders in the intervention group showed greater growth than the comparison group on knowledge of the words taught, on depth of vocabulary knowledge, on understanding multiple meanings, and on reading comprehension. The intervention effects were as la...

Stability and individual change in depressive symptoms among mothers raising young children with ASD: maternal and child correlates.

Abstract: Mothers raising children with Autism Spectrum Disorders (ASD) evidence elevated depressive symptoms, but symptom stability has not been examined. Mothers (N=143) of toddlers with ASD (77% boys) were enrolled and assessed when their children were 18 to 33 months old and followed annually for 2 years. Multilevel modeling revealed no significant change in group depressive symptom level, which was in the moderately elevated range (Intercept=13.67; SE=.96). In contrast, there was significant individual variation in change over time. Child problem behaviors and delayed competence, maternal anxiety symptoms and angry/hostile mood, low parenting efficacy and social supports, and coping styles were associated with depression severity. Only maternal anxiety and parenting efficacy predicted individual change. Many mothers do not appear to adapt, supporting the need for early intervention for maternal well-being.

Effects of warming and altered precipitation on plant and nutrient dynamics of a New England salt marsh

Abstract: Salt marsh structure and function, and consequently ability to support a range of species and to provide ecosystem services, may be affected by climate change. To better understand how salt marshes will respond to warming and associated shifts in precipitation, we conducted a manipulative experiment in a tidal salt marsh in Massachusetts, USA. We exposed two plant communities (one dominated by Spartina patens-Distichlis spicata and one dominated by short form Spartina alterniflora) to five climate manipulations: warming via passive open-topped chambers, doubled precipitation, warming and doubled precipitation, extreme drought via rainout shelter, and ambient conditions. Modest daytime warming increased total aboveground biomass of the S. alterniflora community (24%), but not the S. patens-D. spicata community. Warming also increased maximum stem heights of S. alterniflora (8%), S. patens (8%), and D. spicata (15%). Decomposition was marginally accelerated by warming in the S. alterniflora community. Drought markedly increased total biomass of the S. alterniflora community (53%) and live S. patens (69%), perhaps by alleviating waterlogging of sediments. Decomposition was accelerated by increased precipitation and slowed by drought, particularly in the S. patens-D. spicata community. Flowering phenology responded minimally to the treatments, and pore water salinity, sulfide, ammonium, and phosphate concentrations showed no treatment effects in either plant community. Our results suggest that these salt marsh communities may be resilient to modest amounts of warming and large changes in precipitation. If production increases under climate change, marshes will have a greater ability to keep pace with sea-level rise, although an increase in decomposition could offset this. As long as marshes are not inundated by flooding due to sea-level rise, increases in aboveground biomass and stem heights suggest that marshes may continue to export carbon and nutrients to coastal waters and may be able to increase their carbon storage capability by increasing plant growth under future climate conditions.

Corporate financial crime: social diagnosis and treatment

Abstract: Purpose – The purpose of this viewpoint paper is to assist in finding solutions for the growing moral and social issues of financial crime plaguing corporations today.Design/methodology/approach – Methodology includes the synthesis of existing theories in economic sociology and criminology to “diagnose” and “treat” the existing flaws in corporate structures that have led to malaise and malfeasance. Theories include differential association, self‐control, and control balance, taking into consideration the characteristics of individuals and corporate structures.Findings – Findings suggest that corporate structure has to be critically scrutinized and changes implemented, including close examination of informal and formal communication and salary structures.Practical implications – This paper suggests concrete strategies and policy changes for regulators, corporate decision makers, and academics.Originality/value – The synthesis of existing theories in white collar malfeasance and crime provides a template to...

Knowledge Management Systems Diffusion in Chinese Enterprises: A Multistage Approach Using the Technology-Organization-Environment Framework

Abstract: With the recognition of the importance of organizational knowledge management (KM), researchers have paid increasing attention to knowledge management systems (KMS). However, since most prior studies were conducted in the context of Western societies, we know little about KMS diffusion in other regional contexts. Moreover, even with the increasing recognition of the influence of social factors in KM practices, there is a dearth of studies that examine how unique social cultural factors affect KMS diffusion in specific countries. To fill in this gap, this study develops an integrated framework, with special consideration on the influence of social cultures, to understand KMS diffusion in Chinese enterprises. In our framework, we examine how specific technological, organizational, and social cultural factors can influence the three-stage KMS diffusion process, that is, initiation, adoption, and routinization. This study provides a holistic view of the KMS diffusion in Chinese enterprises with practical guidance for successful KMS implementation.

Introducing English Linguistics

Abstract: Introduction English Linguistics accomplishes this goal in two ways. Unlike traditional text, it takes a top-down approach to language, beginning with the largest unit of linguistic structure, the text, and working it way down through successively smaller structure.