Institution
University of Modena and Reggio Emilia
Education•Modena, Italy•
About: University of Modena and Reggio Emilia is a education organization based out in Modena, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 8179 authors who have published 22418 publications receiving 671337 citations. The organization is also known as: Università degli Studi di Modena e Reggio Emilia & Universita degli Studi di Modena e Reggio Emilia.
Topics: Population, Medicine, Cancer, Context (language use), Computer science
Papers published on a yearly basis
Papers
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TL;DR: Cochrane reviews fared better than systematic reviews published in paper based journals in terms of assessment of methodological quality of primary studies, although they both largely failed to take it into account in the interpretation of results.
Abstract: Objectives To describe how the methodological quality of primary studies is assessed in systematic reviews and whether the quality assessment is taken into account in the interpretation of results. Data sources Cochrane systematic reviews and systematic reviews in paper based journals. Study selection 965 systematic reviews (809 Cochrane reviews and 156 paper based reviews) published between 1995 and 2002. Data synthesis The methodological quality of primary studies was assessed in 854 of the 965 systematic reviews (88.5%). This occurred more often in Cochrane reviews than in paper based reviews (93.9% v 60.3%, P < 0.0001). Overall, only 496 (51.4%) used the quality assessment in the analysis and interpretation of the results or in their discussion, with no significant differences between Cochrane reviews and paper based reviews (52% v 49%, P = 0.58). The tools and methods used for quality assessment varied widely. Conclusions Cochrane reviews fared better than systematic reviews published in paper based journals in terms of assessment of methodological quality of primary studies, although they both largely failed to take it into account in the interpretation of results. Methods for assessment of methodological quality by systematic reviews are still in their infancy and there is substantial room for improvement.
228 citations
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Agency for Science, Technology and Research1, Charité2, University of Cologne3, Istanbul University4, United Arab Emirates University5, University of Chieti-Pescara6, Casa Sollievo della Sofferenza7, University of California, Los Angeles8, Max Planck Society9, University of Jordan10, University of Modena and Reggio Emilia11, University of Otago12, King Edward Memorial Hospital13, Ohio State University14, Royal Children's Hospital15, Innsbruck Medical University16, University of Innsbruck17, Children's Hospital at Westmead18
TL;DR: The authors' findings link mutations in PYCR1 to altered mitochondrial function and progeroid changes in connective tissues, which led to epidermal hypoplasia and blistering that was accompanied by a massive increase of apoptosis.
Abstract: Autosomal recessive cutis laxa (ARCL) describes a group of syndromal disorders that are often associated with a progeroid appearance, lax and wrinkled skin, osteopenia and mental retardation. Homozygosity mapping in several kindreds with ARCL identified a candidate region on chromosome 17q25. By high-throughput sequencing of the entire candidate region, we detected disease-causing mutations in the gene PYCR1. We found that the gene product, an enzyme involved in proline metabolism, localizes to mitochondria. Altered mitochondrial morphology, membrane potential and increased apoptosis rate upon oxidative stress were evident in fibroblasts from affected individuals. Knockdown of the orthologous genes in Xenopus and zebrafish led to epidermal hypoplasia and blistering that was accompanied by a massive increase of apoptosis. Our findings link mutations in PYCR1 to altered mitochondrial function and progeroid changes in connective tissues.
226 citations
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TL;DR: A natural extension of analysis of Tikhonov regularization to the continuous (population) case and study the interplay between the discrete and continuous problems allows to draw a clear connection between the consistency approach in learning theory and the stability convergence property in ill-posed inverse problems.
Abstract: Many works related learning from examples to regularization techniques for inverse problems, emphasizing the strong algorithmic and conceptual analogy of certain learning algorithms with regularization algorithms. In particular it is well known that regularization schemes such as Tikhonov regularization can be effectively used in the context of learning and are closely related to algorithms such as support vector machines. Nevertheless the connection with inverse problem was considered only for the discrete (finite sample) problem and the probabilistic aspects of learning from examples were not taken into account. In this paper we provide a natural extension of such analysis to the continuous (population) case and study the interplay between the discrete and continuous problems. From a theoretical point of view, this allows to draw a clear connection between the consistency approach in learning theory and the stability convergence property in ill-posed inverse problems. The main mathematical result of the paper is a new probabilistic bound for the regularized least-squares algorithm. By means of standard results on the approximation term, the consistency of the algorithm easily follows.
226 citations
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TL;DR: High pre-ART CD4 cell counts, a high CD4/CD8 ratio at baseline, and negative cytomegalovirus serological findings were associated with normalisation, while low ratios wereassociated with increased risk of serious events and deaths.
226 citations
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TL;DR: Theoretical predictions suggest that reducing the laser wavelength can provide the possibility of HR-LIPSS production on principally any metal and makes this laser-writing technology to be flexible, robust and, hence, highly competitive for advanced industrial applications based on surface nanostructuring.
Abstract: Highly regular laser-induced periodic surface structures (HR-LIPSS) have been fabricated on surfaces of Mo, steel alloy and Ti at a record processing speed on large areas and with a record regularity in the obtained sub-wavelength structures. The physical mechanisms governing LIPSS regularity are identified and linked with the decay length (i.e. the mean free path) of the excited surface electromagnetic waves (SEWs). The dispersion of the LIPSS orientation angle well correlates with the SEWs decay length: the shorter this length, the more regular are the LIPSS. A material dependent criterion for obtaining HR-LIPSS is proposed for a large variety of metallic materials. It has been found that decreasing the spot size close to the SEW decay length is a key for covering several cm2 of material surface by HR-LIPSS in a few seconds. Theoretical predictions suggest that reducing the laser wavelength can provide the possibility of HR-LIPSS production on principally any metal. This new achievement in the unprecedented level of control over the laser-induced periodic structure formation makes this laser-writing technology to be flexible, robust and, hence, highly competitive for advanced industrial applications based on surface nanostructuring.
226 citations
Authors
Showing all 8322 results
Name | H-index | Papers | Citations |
---|---|---|---|
Carlo M. Croce | 198 | 1135 | 189007 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Peter M. Rothwell | 134 | 779 | 67382 |
Claudio Franceschi | 120 | 856 | 59868 |
Lorenzo Galluzzi | 118 | 477 | 71436 |
Leonardo M. Fabbri | 109 | 566 | 60838 |
David N. Reinhoudt | 107 | 1082 | 48814 |
Stefano Pileri | 100 | 635 | 43369 |
Andrea Bizzeti | 99 | 1168 | 46880 |
Brian K. Shoichet | 98 | 281 | 40313 |
Dante Gatteschi | 97 | 727 | 48729 |
Roberta Sessoli | 95 | 424 | 41458 |
Thomas A. Buchholz | 93 | 494 | 33409 |
Pier Luigi Zinzani | 92 | 857 | 35476 |