Institution
University of Nottingham
Education•Nottingham, Nottingham, United Kingdom•
About: University of Nottingham is a education organization based out in Nottingham, Nottingham, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 54772 authors who have published 119600 publications receiving 4227408 citations. The organization is also known as: The University of Nottingham & University College, Nottingham.
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TL;DR: In this paper, a large-scale investigation of 40 ESOL classrooms in South Korea involving 27 teachers and more than 1,300 learners was conducted to examine the link between the teachers' motivational teaching practice and their students' language learning motivation.
Abstract: The teacher’s use of motivational strategies is generally believed to enhance student motivation, yet the literature has little empirical evidence to support this claim. Based on a large-scale investigation of 40 ESOL classrooms in South Korea involving 27 teachers and more than 1,300 learners, this study examined the link between the teachers’ motivational teaching practice and their students’ language learning motivation. The students’ motivation was measured by a self-report questionnaire and a classroom observation instrument specifically developed for this investigation, the motivation orientation of language teaching (MOLT). The MOLT observation scheme was also used to assess the teachers’ use of motivational strategies, along with a posthoc rating scale filled in by the observer. The MOLT follows the real-time coding principle of Spada and Frohlich’s (1995) communication orientation of language teaching (COLT) scheme but uses categories of observable teacher behaviors derived from Dornyei’s (2001) motivational strategies framework for foreign language classrooms. The results indicate that the language teachers’ motivational practice is linked to increased levels of the learners’ motivated learning behavior as well as their motivational state.
561 citations
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TL;DR: This work has shown that when a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
Abstract: Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
560 citations
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Durham University1, Carnegie Mellon University2, University of New South Wales3, Johns Hopkins University4, Australian National University5, Liverpool John Moores University6, University of St Andrews7, University of Cambridge8, California Institute of Technology9, University of Nottingham10, ETH Zurich11, University of Edinburgh12
TL;DR: In this article, the authors analyzed the observed correlation between galaxy environment and Halpha emission-line strength, using volume-limited samples and group catalogues of 24 968 galaxies at 0.05 < z < 0.095, drawn from the 2dF Galaxy Redshift Survey (M-bJ < -19.5) and the Sloan Digital Sky Survey(M-r < -20.6).
Abstract: We analyse the observed correlation between galaxy environment and Halpha emission-line strength, using volume-limited samples and group catalogues of 24 968 galaxies at 0.05 < z < 0.095, drawn from the 2dF Galaxy Redshift Survey (M-bJ < -19.5) and the Sloan Digital Sky Survey (M-r < -20.6). We characterize the environment by: (1) Sigma(5), the surface number density of galaxies determined by the projected distance to the fifth nearest neighbour; and (2) rho(1.1) and rho(5.5), three-dimensional density estimates obtained by convolving the galaxy distribution with Gaussian kernels of dispersion 1.1 and 5.5 Mpc, respectively. We find that star-forming and quiescent galaxies form two distinct populations, as characterized by their H equivalent width, W-0(Halpha). The relative numbers of star-forming and quiescent galaxies vary strongly and continuously with local density. However, the distribution of W-0(Halpha) amongst the star-forming population is independent of environment. The fraction of star-forming galaxies shows strong sensitivity to the density on large scales, rho(5.5), which is likely independent of the trend with local density, rho(1.1). We use two differently selected group catalogues to demonstrate that the correlation with galaxy density is approximately independent of group velocity dispersion, for sigma = 200-1000 km s(-1). Even in the lowest-density environments, no more than similar to70 per cent of galaxies show significant Halpha emission. Based on these results, we conclude that the present-day correlation between star formation rate and environment is a result of short-time-scale mechanisms that take place preferentially at high redshift, such as starbursts induced by galaxy-galaxy interactions.
560 citations
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TL;DR: In this paper, the authors consider epidemics with removal (SIR) in populations that mix at two levels: global and local, and develop a general modelling framework for such processes, which allows them to analyze the conditions under which a large outbreak is possible, the size of such outbreaks when they can occur and the implications for vaccination strategies, in each case comparing their results with the simpler homogeneous mixing case.
Abstract: We consider epidemics with removal (SIR epidemics) in populations that mix at two levels: global and local. We develop a general modelling framework for such processes, which allows us to analyze the conditions under which a large outbreak is possible, the size of such outbreaks when they can occur and the implications for vaccination strategies, in each case comparing our results with the simpler homogeneous mixing case. More precisely, we consider models in which each infectious individual i has a global probability $p_G$ for infecting each other individual in the population and a local probability $p_L$, typically much larger, of infecting each other individual among a set of neighbors $\mathscr{N}(i)$. Our main concern is the case where the population is partitioned into local groups or households, but our approach also applies to cases where neighborhoods do not form a partition, for instance, to spatial models with a mixture of local (e.g., nearest-neighbor) and global contacts. We use a variety of theoretical approaches: a random graph framework for the initial exposition of the simple case where an individual's contacts are independent; branching process approximations for the general threshold result; and an embedding representation for rigorous results on the final size of outbreaks. From the applied viewpoint the key result is that, compared with the homogeneous mixing model in which individuals make contacts simply with probability $p_G$, the local infectious contacts have an "amplification" effect. The basic reproductive ratio of the epidemic is increased from its individual-to-individual value $R_G$ in the absence of local infections to a group-to-group value $R_* = \mu R_G$, where $\mu$ is the mean size of an outbreak, started by a randomly chosen individual, in which only local infections count. Where the groups are large and the within-group epidemics are above threshold, this amplification can permit an outbreak in the whole population at very low levels of $p_G$, for instance, for $p_G = O(1/Nn)$ in a population of N divided into groups of size n. The implication of these results for control strategies is that vaccination should be directed preferentially toward reducing $\mu$; we discuss the conditions under which the equalizing strategy, aimed at leaving unvaccinated sets of neighbors of equal sizes, is optimal. We also discuss the estimation of our threshold parameter $R_*$ from data on epidemics among households.
559 citations
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TL;DR: It is shown that 2‐heptyl‐3‐hydroxy‐4(1H)‐quinolone (PQS) is also an integral component of the quorum sensing circuitry and is required for the production of rhl‐dependent exoproducts at the onset of stationary phase of Pseudomonas aeruginosa.
Abstract: In Pseudomonas aeruginosa, diverse exoproduct virulence determinants are regulated via N-acylhomoserine lactone-dependent quorum sensing. Here we show that 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS) is also an integral component of the quorum sensing circuitry and is required for the production of rhl-dependent exoproducts at the onset of stationary phase. Analysis of spent P. aeruginosa culture supernatants revealed that PQS is produced at the end of exponential phase in the parent strain and in the late stationary phase of a lasR mutant. Mutants defective in both PQS production (pqsR-) and response (pqsE-) produced substantially reduced levels of exoproducts but retained wild-type N-butanoyl homoserine lactone (C4-HSL) levels. In the wild type, provision of exogenous PQS at the time of inoculation significantly increased PA-IL lectin, pyocyanin and elastase production during early stationary phase and promoted biofilm formation. Exogenous PQS but not PQS derivatives lacking the 3-hydroxy group overcame the cell density but not growth phase-dependent production of exoproducts. PQS also overcame the transcriptional and post-transcriptional repression of lecA (which codes for the PA-IL lectin) mediated via the negative regulators MvaT and RsmA respectively. Increased expression of lecA in the presence of exogenous PQS can be explained partially by increases in RhlR, RpoS and C4-HSL levels. A refined model for quorum sensing in P. aeruginosa is presented.
559 citations
Authors
Showing all 55289 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Robert M. Califf | 196 | 1561 | 167961 |
Eric J. Topol | 193 | 1373 | 151025 |
Simon D. M. White | 189 | 795 | 231645 |
Douglas F. Easton | 165 | 844 | 113809 |
Elliott M. Antman | 161 | 716 | 179462 |
Pete Smith | 156 | 2464 | 138819 |
Christopher P. Cannon | 151 | 1118 | 108906 |
Scott T. Weiss | 147 | 1025 | 74742 |
Frede Blaabjerg | 147 | 2161 | 112017 |
Martin J. Blaser | 147 | 820 | 104104 |
Stephen Sanders | 145 | 1385 | 105943 |
Stuart J. Pocock | 145 | 684 | 143547 |
Peter B. Jones | 145 | 1857 | 94641 |
Alexander Belyaev | 142 | 1895 | 100796 |