Institution
University of Nottingham
Education•Nottingham, Nottingham, United Kingdom•
About: University of Nottingham is a education organization based out in Nottingham, Nottingham, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 54772 authors who have published 119600 publications receiving 4227408 citations. The organization is also known as: The University of Nottingham & University College, Nottingham.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors derived a correlation for the Nusselt number of the form suggested by this evidence using a selection of the data and showed that this exponent should be a function of nozzle-to-plate spacing and of the radial displacement from the stagnation point.
1,030 citations
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TL;DR: The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) database provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome, and provides an expanded substrate for the biennially published compendium, the Concise Guide topharmacology.
Abstract: The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options.
1,030 citations
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TL;DR: Eleven evidence-based recommendations for the non-pharmacological core management of hip and knee OA were developed, concerning the following nine topics: assessment, general approach, patient information and education, lifestyle changes, exercise, weight loss, assistive technology and adaptations, footwear and work.
Abstract: The objective was to develop evidence -based recommendations and a research and educational agenda for the non-pharmacological management of hip and knee osteoarthritis (OA). The multidisciplinary task force comprised 21 experts: nurses, occupational therapists, physiotherapists, rheumatologists, orthopaedic surgeons, general practitioner, psychologist, dietician, clinical epidemiologist and patient representatives. After a preliminary literature review, a first task force meeting and five Delphi rounds, provisional recommendations were formulated in order to perform a systematic review. A literature search of Medline and eight other databases was performed up to February 2012. Evidence was graded in categories I-IV and agreement with the recommendations was determined through scores from 0 (total disagreement) to 10 (total agreement). Eleven evidence-based recommendations for the non-pharmacological core management of hip and knee OA were developed, concerning the following nine topics: assessment, general approach, patient information and education, lifestyle changes, exercise, weight loss, assistive technology and adaptations, footwear and work. The average level of agreement ranged between 8.0 and 9.1. The proposed research agenda included an overall need for more research into non-pharmacological interventions for hip OA, moderators to optimise individualised treatment, healthy lifestyle with economic evaluation and long-term follow-up, and the prevention and reduction of work disability. Proposed educational activities included the required skills to teach, initiate and establish lifestyle changes. The 11 recommendations provide guidance on the delivery of non-pharmacological interventions to people with hip or knee OA. More research and educational activities are needed, particularly in the area of lifestyle changes.
1,029 citations
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TL;DR: IL-1Ra is the first biologic agent to demonstrate a beneficial effect on the rate of joint erosion and is confirmed both the efficacy and the safety in a large cohort of patients with active and severe RA.
Abstract: Objective
To evaluate the efficacy and safety of interleukin-1 receptor antagonist (IL-1Ra) in patients with rheumatoid arthritis (RA).
Methods
Patients with active and severe RA (disease duration <8 years) were recruited into a 24-week, double-blind, randomized, placebo-controlled, multicenter study. Doses of nonsteroidal antiinflammatory drugs and/or oral corticosteroids (≤10 mg prednisolone daily) remained constant throughout the study. Any disease-modifying antirheumatic drugs that were being administered were discontinued at least 6 weeks prior to enrollment. Patients were randomized to 1 of 4 treatment groups: placebo or a single, self-administered subcutaneous injection of IL-1Ra at a daily dose of 30 mg, 75 mg, or 150 mg.
Results
A total of 472 patients were recruited. At enrollment, the mean age, sex ratio, disease duration, and percentage of patients with rheumatoid factor and erosions were similar in the 4 treatment groups. The clinical parameters of disease activity were similar in each treatment group and were consistent with active and severe RA. At 24 weeks, of the patients who received 150 mg/day IL-1Ra, 43% met the American College of Rheumatology criteria for response (the primary efficacy measure), 44% met the Paulus criteria, and statistically significant improvements were seen in the number of swollen joints, number of tender joints, investigator's assessment of disease activity, patient's assessment of disease activity, pain score on a visual analog scale, duration of morning stiffness, Health Assessment Questionnaire score, C-reactive protein level, and erythrocyte sedimentation rate. In addition, the rate of radiologic progression in the patients receiving IL-1Ra was significantly less than in the placebo group at 24 weeks, as evidenced by the Larsen score and the erosive joint count. IL-1Ra was well tolerated and no serious adverse events were observed. An injection-site reaction was the most frequently observed adverse event, and this resulted in a 5% rate of withdrawal from the study among those receiving IL-1Ra at 150 mg/day.
Conclusion
This study confirmed both the efficacy and the safety of IL-1Ra in a large cohort of patients with active and severe RA. IL-1Ra is the first biologic agent to demonstrate a beneficial effect on the rate of joint erosion.
1,028 citations
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ETH Zurich1, Centre national de la recherche scientifique2, University of Padua3, INAF4, Max Planck Society5, Brera Astronomical Observatory6, California Institute of Technology7, Paris Diderot University8, Institut d'Astrophysique de Paris9, University of Hawaii10, Tohoku University11, University of Nottingham12, University of Arizona13, Space Telescope Science Institute14, University of Bologna15, European Southern Observatory16, University of Edinburgh17, Columbia University18, Durham University19
TL;DR: The zCOSMOS-bright survey as discussed by the authors is a large-redshift survey that is being undertaken in the CosMOS field using 600 hr of observation with the VIMOS spectrograph on the 8 m VLT.
Abstract: zCOSMOS is a large-redshift survey that is being undertaken in the COSMOS field using 600 hr of observation
with the VIMOS spectrograph on the 8 m VLT. The survey is designed to characterize the environments of COSMOS
galaxies from the 100 kpc scales of galaxy groups up to the 100 Mpc scale of the cosmic web and to produce diagnostic
information on galaxies and active galactic nuclei. The zCOSMOS survey consists of two parts: (1) zCOSMOSbright,
a magnitude-limited I-band I_(AB) < 22.5 sample of about 20,000 galaxies with 0.1 < z < 1.2 covering the whole
1.7 deg^2 COSMOS ACS field, for which the survey parameters at z ~ 0.7 are designed to be directly comparable to
those of the 2dFGRS at z ~ 0.1; and (2) zCOSMOS-deep, a survey of approximately 10,000 galaxies selected through
color-selection criteria to have 1.4 < z < 3.0, within the central 1 deg^2. This paper describes the survey design and the
construction of the target catalogs and briefly outlines the observational program and the data pipeline. In the first
observing season, spectra of 1303 zCOSMOS-bright targets and 977 zCOSMOS-deep targets have been obtained.
These are briefly analyzed to demonstrate the characteristics that may be expected from zCOSMOS, and particularly
zCOSMOS-bright, when it is finally completed between 2008 and 2009. The power of combining spectroscopic and
photometric redshifts is demonstrated, especially in correctly identifying the emission line in single-line spectra and in
determining which of the less reliable spectroscopic redshifts are correct and which are incorrect. These techniques
bring the overall success rate in the zCOSMOS-bright so far to almost 90% and to above 97% in the 0.5 < z < 0.8
redshift range. Our zCOSMOS-deep spectra demonstrate the power of our selection techniques to isolate high-redshift
galaxies at 1.4 < z < 3.0 and of VIMOS to measure their redshifts using ultraviolet absorption lines.
1,026 citations
Authors
Showing all 55289 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Robert M. Califf | 196 | 1561 | 167961 |
Eric J. Topol | 193 | 1373 | 151025 |
Simon D. M. White | 189 | 795 | 231645 |
Douglas F. Easton | 165 | 844 | 113809 |
Elliott M. Antman | 161 | 716 | 179462 |
Pete Smith | 156 | 2464 | 138819 |
Christopher P. Cannon | 151 | 1118 | 108906 |
Scott T. Weiss | 147 | 1025 | 74742 |
Frede Blaabjerg | 147 | 2161 | 112017 |
Martin J. Blaser | 147 | 820 | 104104 |
Stephen Sanders | 145 | 1385 | 105943 |
Stuart J. Pocock | 145 | 684 | 143547 |
Peter B. Jones | 145 | 1857 | 94641 |
Alexander Belyaev | 142 | 1895 | 100796 |