University of Nottingham

About: University of Nottingham is a education organization based out in Nottingham, Nottingham, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 54772 authors who have published 119600 publications receiving 4227408 citations. The organization is also known as: The University of Nottingham & University College, Nottingham.

Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update.

Abstract: Purpose.— To update key recommendations of the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) human epidermal growth factor receptor 2 (HER2) testing in breast ...

Human CD14 mediates recognition and phagocytosis of apoptotic cells

Abstract: Cells undergoing programmed cell death (apoptosis) are cleared rapidly in vivo by phagocytes without inducing inflammation1. Here we show that the glycosylphosphatidylinositol-linked plasma-membrane glycoprotein CD14 (refs 2, 3) on the surface of human macrophages is important for the recognition and clearance of apoptotic cells. CD14 can also act as a receptor that binds bacterial lipopolysaccharide (LPS), triggering inflammatory responses4. Overstimulation of CD14 by LPS can cause the often fatal toxic-shock syndrome5,6. Here we show that apoptotic cells interact with CD14, triggering phagocytosis of the apoptotic cells. This interaction depends on a region of CD14 that is identical to, or at least closely associated with, a region known to bind LPS. However, apoptotic cells, unlike LPS, do not provoke the release of pro-inflammatory cytokines from macrophages. These results indicate that clearance of apoptotic cells is mediated by a receptor whose interactions with ‘non-self’ components (LPS) and ‘self’ components (apoptotic cells) produce distinct macrophage responses.

Galaxy Zoo 1: data release of morphological classifications for nearly 900 000 galaxies

Abstract: Morphology is a powerful indicator of a galaxy’s dynamical and merger history. It is strongly correlated with many physical parameters, including mass, star formation history and the distribution of mass. The Galaxy Zoo project collected simple morphological classifications of nearly 900 000 galaxies drawn from the Sloan Digital Sky Survey, contributed by hundreds of thousands of volunteers. This large number of classifications allows us to exclude classifier error, and measure the influence of subtle biases inherent in morphological classification. This paper presents the data collected by the project, alongside measures of classification accuracy and bias. The data are now publicly available and full catalogues can be downloaded in electronic format from http://data.galaxyzoo.org.

Spaces of Global Capitalism: Towards a Theory of Uneven Geographical Development

Abstract: to the rise of a neoliberalism which has both commoditized otherness and stripped away the buffers of the welfare state. The introduction establishes that, although Brennan critiques the formation of \"theory,\" he is not dismissive of theory in principle; he actually is deeply invested in a trajectory of theory, embodied in the Hegel-Marx line: Bakhtin, Lukács, Benjamin, Adorno, Marcuse, Gramsci, Bourdieu, and Said. Lamenting the predominance of the Nietszchèan line—in which he includes Heidegger, Deleuze and Guattari, Baudrillard, Lyotard, Derrida, Vattimo, Negri, and Virilio—Brennan blasts the celebratory and uncritical use of \"poststructuralism's infinitely interchangeable metaphors of dispersal: decentered subjects, nomadism, ambivalence, the supplement, rhizomatic identity, and the constructed self—terms whose sheer quantity nervously intimates a lack of variation.\" At such polemical textual moments, we feel the full force of Brennan's bile at a discipline that has abnegated its responsibilities; at the same time, the polemic (as all polemics do) tends to create the fantasy of an other whose totality is self-evident and whose heterogeneity is merely superficial. What, indeed, about the politically engaged work of Cary Nelson, BarrettWatten, Michael Bibby, andMichael True, among others, not to mention the intellectuals left of Noam Chomsky, whose dissident work may share the anarchism of the academic left, but whose consequences have been real and whose relationship to dissenting movements in the US and throughout the world is undeniable? (Chomsky gets three short mentions in this book.) Brennan's relative exclusion of contemporary examples of Gramscian intellectuals actively engaged with social movements makes Wars ofPosition a difficult book, because it offers few models for emerging from the malaise that the academy seems to Detailfrom cover suffer from. Yet Brennan is clearly at his best when he is arguing against the received versions of theorists, engaging his Hegelian impulses to reverse the unexamined consensus. His critical reassessment of Orientalism (1978), for example, suggests that Said's foundational text on the Western fantasies of the Middle East has been misread as a Foucauldian project; rather, for Brennan, while Orientalism clearly borrows heavily from Foucault, Said ultimately is arguing against the poststructuralist doxa that underwrite much of contemporary postcolonial theory. Said, in Brennan's reading, is a crucial figure not only for his resistance to the sacred cows of poststructuralism, but also for his embrace of the public responsibilities of the intellectual.

Apoptosis in resolution of inflammation

Abstract: The last few years have seen the accumu- lation of compelling evidence that apoptosis (pro- grammed cell death) plays a major role in promoting resolution of the acute inflammatory response. Neutro- pulls are constitutively programmed to undergo apop- tosis, which limits their pro-inflammatory potential and leads to rapid, specific, and non-phlogistic recognition