Institution
University of South Africa
Education•Pretoria, South Africa•
About: University of South Africa is a education organization based out in Pretoria, South Africa. It is known for research contribution in the topics: Context (language use) & Population. The organization has 8478 authors who have published 19960 publications receiving 237688 citations. The organization is also known as: Unisa.
Papers published on a yearly basis
Papers
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TL;DR: In vitro and in vivo validation is needed to study and develop an anti-COVID-19 drug based on the structures of the most promising compounds identified in this study.
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused about 2 million infections and is responsible for more than 100,000 deaths worldwide. To date, there is no specific drug registered to combat the disease it causes, named coronavirus disease 2019 (COVID-19). In the current study, we used an in silico approach to screen natural compounds to find potent inhibitors of the host enzyme transmembrane protease serine 2 (TMPRSS2). This enzyme facilitates viral particle entry into host cells, and its inhibition blocks virus fusion with angiotensin-converting enzyme 2 (ACE2). This, in turn, restricts SARS-CoV-2 pathogenesis. A three-dimensional structure of TMPRSS2 was built using SWISS-MODEL and validated by RAMPAGE. The natural compounds library Natural Product Activity and Species Source (NPASS), containing 30,927 compounds, was screened against the target protein. Two techniques were used in the Molecular Operating Environment (MOE) for this purpose, i.e., a ligand-based pharmacophore approach and a molecular docking-based screening. In total, 2140 compounds with pharmacophoric features were retained using the first approach. Using the second approach, 85 compounds with molecular docking comparable to or greater than that of the standard inhibitor (camostat mesylate) were identified. The top 12 compounds with the most favorable structural features were studied for physicochemical and ADMET (absorption, distribution, metabolism, excretion, toxicity) properties. The low-molecular-weight compound NPC306344 showed significant interaction with the active site residues of TMPRSS2, with a binding energy score of -14.69. Further in vitro and in vivo validation is needed to study and develop an anti-COVID-19 drug based on the structures of the most promising compounds identified in this study.
134 citations
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TL;DR: MnO2 and g-C3N4 heterostructure were constructed by simple solgel technique combined with annealing process were characterized different variety of techniques to understand the structural, morphological, optical and elemental composition were using XRD, TEM, Raman, UV, PL, BET and EDAX analysis as discussed by the authors.
134 citations
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TL;DR: Countries should first identify their health problems in order to properly address their health worker needs, retention, recruitment and training, if they are to come close to reaching the Millennium Development Goals (MDGs) for health.
Abstract: With increased globalization and interdependence among countries, sustained health worker migration and the complex threats of rapidly spreading infectious diseases, as well as changing lifestyles, a strong health workforce is essential. Building the human resources for health should not only include healthcare professionals like physicians and nurses, but must take into consideration community health workers, mid-level workers and strengthened primary healthcare systems to increase coverage and address the basic health needs of societies. This is especially true in low and middle-income countries where healthcare access is a critical challenge. There is a global crisis in the health workforce, expressed in acute shortages and maldistribution of health workers, geographically and professionally. This massive global shortage, though imprecise quantitatively, is estimated at more than 4 million workers. To respond to this crisis, policies and actions are needed to address the dynamics of the health labour market and the production and management of the health workforce, and to strengthen the performance of existing health systems. Schools of public health need to develop the range of capacity and leadership in addition to the traditional training of healthcare managers and researchers. Countries should first identify their health problems in order to properly address their health worker needs, retention, recruitment and training, if they are to come close to reaching the Millennium Development Goals (MDGs) for health.
134 citations
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TL;DR: In this paper, the authors apply the bounds testing approach to cointegration within an autoregressive distributed lag framework to examine the aggregate demand for electricity in South Africa during the period 1960-2007.
133 citations
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TL;DR: In this article, MgO decked few layer Graphene Coated Fullers' Earth (MgO-FLG-FE) was used as an adsorbent to remove acid blue 9 (AB9) and Safranin O (SO) dye from aqueous solutions.
133 citations
Authors
Showing all 8743 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alvaro Avezum | 93 | 279 | 48888 |
Jordan J. Louviere | 93 | 356 | 38739 |
Jürgen Eckert | 92 | 1368 | 42119 |
Simon Henry Connell | 83 | 506 | 25147 |
Elina Hyppönen | 81 | 258 | 33011 |
David Wilkinson | 80 | 631 | 27578 |
Béla Bollobás | 78 | 566 | 34767 |
Richard A. Matzner | 72 | 317 | 16389 |
Tim Olds | 71 | 412 | 21758 |
Nicolin Govender | 71 | 412 | 18740 |
Paul A. Webley | 70 | 374 | 18633 |
Dusan Losic | 70 | 398 | 16550 |
Alexander Shapiro | 70 | 252 | 26450 |
Kerin O'Dea | 69 | 359 | 16435 |
Shrikant I. Bangdiwala | 68 | 359 | 21650 |