University of Texas System

About: University of Texas System is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 13901 authors who have published 10925 publications receiving 319328 citations. The organization is also known as: UT System.

The relationship of acute to late skin injury in 2 and 5 fraction/week γ-ray therapy

Abstract: Areas of pigs' skin were exposed to fractionated doses of ..gamma.. rays, and their acute and late (several months) responses were measured as desquamation and degree of contraction, respectively. The purpose was to measure the relative changes in acute and late response when the dose fractionation pattern of a 6.5 week treatment was changed from five times to twice weekly. It was found that NSD formula did not predict isoeffect for reduced numbers of dose-fractions. Moreover, early skin response did not predict the magnitude of late damage when dose-fractionation was altered from conventional daily routines. Specifically, 200 rad five times weekly was equivalent, for acute response, to a dose greater than 435 rad twice weekly (p<0.01), whereas, for late response, equivalence was achieved at a dose less than 360 rad twice weekly (p<0.0526).

Prophylaxis and therapy of acquired immunodeficiency syndrome

Abstract: An active peptide consisting essentially of 7 to about 30 residence and having a sequence that corresponds to a conserved domain of an HIV protein is disclosed, as is a multimer containing that peptide, an aqueous composition containing the multimer and methods of using and making the same. The aqueous composition containing an immunologically effective amount of an active peptide multimer, when introduced into an immunocompetent host animal in an immunologically effective amount, is capable of inducing cellular immunity against the native HIV protein to which the active peptide of the multimer corresponds in sequence, but is not capable of inducing production of antibodies that immunoreact with that native HIV protein.

Mapping G1 phase by the structural morphology of the prematurely condensed chromosomes

Abstract: The object of this study was to develop a map of G1 phase on the basis of the progressive changes taking place in the morphology of the prematurely condensed chromosomes as the cells traverse through G1 and then use this technique to determine the cell cycle location of normal and transformed cell populations in plateau phase. The morphology of the prematurely condensed chromosomes (PCC) of G1 cells in random populations was found to be highly variable. For a better understanding of the relationship between the morphology of the G1-PCC and their position within G1 phase, synchronized populations of Chinese hamster ovary (CHO) cells in early, mid-, and late G1 phase were fused with mitotic cells. Early G1 cells resulted in highly condensed G1-PCC, while late G1 cells gave very extended G1-PCC. Mid-G1 cells resulted in PCC of intermediate condensation. To test the validity of these criteria for mapping the position of a cell in the cell cycle, synchronous G1 cell populations were treated with a variety of metabolic inhibitors. Cycloheximide and actinomycin D were shown to block cell in early G1 phase, while excess thymidine and hydroxyurea blocked cells in early S phase. The results presented here indicate that, upon reaching plateau phase, normal cell populations (BALB-C mouse 3T3, human PA-2, and WI 38) stop in early G1, while most cells in transformed cell lines (CHO, HeLa, and mouse SV-3T3) accumulate in late G1.