scispace - formally typeset
Search or ask a question
Institution

University of Texas System

EducationAustin, Texas, United States
About: University of Texas System is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 13901 authors who have published 10925 publications receiving 319328 citations. The organization is also known as: UT System.
Topics: Cancer, Population, Antigen, Gene, Antibody


Papers
More filters
Journal ArticleDOI
TL;DR: Design of MAIQ-1, a derivative of this class with strong inhibitory potency for ribonucleoside diphosphate reductase activity, as well as the other necessary requisite properties for clinical trial as an antineoplastic agent is proposed.

119 citations

Patent
16 Jul 1992
TL;DR: In this article, a solution of a single polylactide enantiomer is gelled to produce solid materials, or may be extracted with a nonsolvent prior to drying to make microporous materials.
Abstract: Resorbable materials and their preparation based on gelling a solution of a single polylactide enantiomer. The gel may be dried to produce solid materials, or may be extracted with a nonsolvent prior to drying to make microporous materials. Physical and mechanical properties of the material may be varied by varying the molecular weight of the gelling polymer, or by blending the gelling solution with other polymers or fillers. The resorbable materials can be used to make biodegradable implantation devices.

119 citations

Patent
16 Apr 1997
TL;DR: In this paper, the authors describe a new approach to three-dimensional molecular tailoring of surfaces, in which a plasma deposition step is initially employed to deposit reactive functional groups on the surface of a solid substrate, then immersion of the coated substrate in a solution during which time solute molecules react with the functional surface groups introduced during the plasma process.
Abstract: This invention describes a new approach to three-dimensional molecular tailoring of surfaces. In this process, a plasma deposition step is initally employed to deposit reactive functional groups on the surface of a solid substrate. This is then followed by immersion of the coated substrate in a solution during which time solute molecules react with the functional surface groups introduced during the plasma process. Solute molecules are attached to the surface during this second step. This simple two-step process is of general utility in that both the nature of the plasma introduced surface group and the nature of the solute molecules can be varied. Additionally it is possible to provide exact control of the surface density of reactive groups introduced during the plasma process and thus the concentration of solute molecules coupled to the solid surfaces. A particularly significant aspect of this invention is that the second step chemical derivatization reactions can be carried out using aqueous solutions at room temperature. The RF plasma polymerization of substituted perfluorohexenes is shown to produce films having unusually high -CF3 content. These films are produced under both pulsed and continuous-wave plasma deposition conditions. The relative -CF3 content of these polymers increases with decreasing average RF power absorbed during the film formation processes. The films produced under the least energetic condition (i.e., pulsed plasma, 0.1 ms on/3.0 ms off and 100 watts peak power) are exceptionally hydrophobic, exhibiting advancing and receding water contact angles in excess of those observed with Teflon® surfaces. The most hydrophobic films have a -CF3 content which represents 40 % of the carbon atoms present in the sample.

119 citations

Journal ArticleDOI
TL;DR: It is demonstrated that nuclear matrices prepared from the yeast Saccharomyces cerevisiae will specifically bind an MAR sequence derived from the mouse kappa light chain immunoglobulin gene, suggesting that both MAR sequences and their binding sites have been strongly evolutionarily conserved.

119 citations

Journal ArticleDOI
01 Sep 1988-Blood
TL;DR: A combined method of S1 nuclease protection and polymerase chain reaction is used to amplified sequences representative of the chimeric bcr/abl transcripts, which have the potential to identify a subpopulation of Ph1-positive CML patients in remission who are at high risk of relapse.

119 citations


Authors

Showing all 13902 results

NameH-indexPapersCitations
Yi Chen2174342293080
Joseph L. Goldstein207556149527
Eric N. Olson206814144586
Hagop M. Kantarjian2043708210208
Thomas C. Südhof191653118007
Gordon B. Mills1871273186451
Michael S. Brown185422123723
Eric Boerwinkle1831321170971
Russel J. Reiter1691646121010
John D. Minna169951106363
Timothy A. Springer167669122421
Gabriel N. Hortobagyi1661374104845
Rodney S. Ruoff164666194902
Ralph A. DeFronzo160759132993
Ronald A. DePinho160486104039
Network Information
Related Institutions (5)
Memorial Sloan Kettering Cancer Center
65.3K papers, 4.4M citations

87% related

National Institutes of Health
297.8K papers, 21.3M citations

87% related

University of Texas Southwestern Medical Center
75.2K papers, 4.4M citations

87% related

University of Pittsburgh
201K papers, 9.6M citations

87% related

University of Texas MD Anderson Cancer Center
92.5K papers, 4.7M citations

87% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20222
2021123
2020197
2019239
2018248
2017290