University of Texas System

About: University of Texas System is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 13901 authors who have published 10925 publications receiving 319328 citations. The organization is also known as: UT System.

Iontophoretic device and method for killing bacteria and other microbes

Abstract: An apparatus and method for killing microbes, including bacteria or yeast-like fungus within or on a conductive medium, is provided including positive and negative electrodes which may be activated to generate antimicrobial agents from within the conductive medium. The agents are any form of anions including atoms or molecules derived from inorganic salts present within the conductive medium. Due to residual killing effect caused by the presence of internally generated antimicrobial agents, constant activation of the electrodes is not necessary thereby allowing intermittent activation in order to prolong the life of the metallic or non-metallic electrodes. Electrode polarity can be reversed periodically to drive precipitation from the electrode surface and to also extend electrode life.

The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents.

Abstract: Mammalian target of rapamycin (mTOR) has emerged as an important target for cancer therapy. Rapamycin has a distinct, well-documented toxicity profile and most of the toxicity data has been reported in patients with organ transplantation. Newer mTOR inhibitors have slightly different pharmacokinetic properties, yet they present toxicity profiles similar to rapamycin. Most of these toxicities are mild to moderate in severity and can be managed clinically by dose modification and supportive measures. Mucositis and pneumonitis are the most commonly reported toxicities, but they rarely lead to treatment discontinuation. Pathogenesis of pneumonitis is uncertain, but various hypotheses have been suggested, including cell-mediated immune response to the drug.

Localized Ewing's sarcoma--treatment and results.

Abstract: The experience at M. D. Anderson Hospital in the management of 59 patients with apparently localized Ewing's sarcoma from 1948 to May, 1972 is presented. Necropsy examination was performed in 18 cases. Disease-free survival times are compared between 19 patients treated by the combination of high-dose irradiation and intensive chemotherapy, and 40 patients treated by radiation therapy alone (25) or in combination with relatively less intensive drug therapy (15). Results favor the former group: local recurrence in 1 case of 19 compared to 19 of 40; and median time to first metastasis of >15 months compared to 8 months.

Conservation surgery and irradiation for the treatment of favorable breast cancer.

Abstract: The results in 162 patients with clinically favorable breast cancer treated with conservation surgery and radiation therapy are presented. The surgical procedures were simple excision with and without positive microscopic margins, segmental mastectomy, and segmental mastectomy with axillary dissection. Details of the radiation techniques are described with an explanation of the modifications in technique depending on the prior surgical procedure. Excellent control of local and regional tumor (96%) gives support to the combined treatment without removing the breast.