University of Texas System

About: University of Texas System is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 13901 authors who have published 10925 publications receiving 319328 citations. The organization is also known as: UT System.

Delivery system and method for deployment and endovascular assembly of multi-stage stent graft

Abstract: This invention is a coaxial delivery system for the delivery, and endo-vascular assembly of a multi-stage stent graft. Each stage or layer of the stent graft may comprise radially compressible spring portions (9). The system may have a first sheath (11) which comprises a first portion (12) to enclose a stage (2), and a second portion (20) smaller than the first portion (12). The system further has a second sheath (24) configured to enclose the second portion (20) of the first sheath (11), and another stage (4, 3). The multi-stage stent graft may be formed by the stage (2), and the stage (4, 3).

Multimodal treatment of locoregionally advanced breast cancer.

Abstract: Fifty-two patients with locally advanced primary breast cancer (T3, T4/N2, N3) without distant metastases were treated with three cycles of combination chemotherapy consisting of 5-FU, Adriamycin and cyclophosphamide (FAC) and immunotherapy with Bacillus Calmette-Guerin (BCG) followed by local therapy (simple mastectomy and/or radiotherapy to breast/chest wall and regional lymphatics) and adjuvant chemotherapy to complete two years of treatment. Forty-nine of 52 (94%) patients were rendered free of clinically detectable disease. The median disease-free interval was 24 months. At a median follow-up time of 60 months, 40% of patients remained free of disease, off all therapy. Those patients who completed two years of therapy and started adjuvant chemotherapy promptly after local treatment had a 48% disease-free survival at five years. Local recurrences were observed in 21% of patients. Distant metastases developed in 40% of patients. Despite good tolerance, treatment compliance was poor. The complete remission rate with this multimodal approach is high and long-term disease-free survival is achieved in a considerable number of patients.

B cells expressing CD5 are increased in Sjögren's syndrome.

Abstract: In this investigation of B cells expressing the CD5 (Leu-1) cell surface marker, we found increased numbers of these cells in 13 of 19 patients with primary Sjogren's syndrome (SS) (68%), as well as in the rheumatoid arthritis patients. The percentage of B cells that demonstrated increased expression of CD5 was 46% in SS patients, 47% in rheumatoid arthritis patients, 24% in systemic lupus erythematosus patients, and 26% in normal subjects. Over a 2-year period, CD5 expression on B cells was a stable finding in several patients, except for 2 who required either steroid therapy or combined chemotherapy and irradiation for malignant lymphoma. Both of these patients had clinical remissions and their levels of CD5+ B cells returned to normal. The first patient had a clinical picture of SS/systemic lupus erythematosus overlap, associated with polyclonal B cell activation and decreased production of interleukin-2 in response to stimulation with phytohemagglutinin. These cellular immune abnormalities returned to normal after the institution of corticosteroids. Our observations suggest a relationship between the CD5+ B cell abnormality and disease activity. The results are discussed in relation to immunoregulatory properties of CD5+ B cells in autoimmune mice and the characteristic predisposition to malignant lymphoma among SS patients.

A Comparison of Techniques for Coupling Porous Flow and Geomechanics

Abstract: Summary This paper compares three techniques for coupling multiphase porous flow and geomechanics. Sample simulations are presented to highlight the similarities and differences in the techniques. One technique uses an explicit algorithm to couple porous flow and displacements in which flow calculations are performed every timestep and displacements are calculated only during selected timesteps. A second technique uses an iteratively coupled algorithm in which flow calculations and displacement calculations are performed sequentially for the nonlinear iterations during each timestep. The third technique uses a fully coupled approach in which the program’s linear solver must solve simultaneously for fluid-flow variables and displacement variables. The techniques for coupling porous flow with displacements are described and comparison problems are presented for single-phase and threephase flow problems involving poroelastic deformations. All problems in this paper are described in detail, so the results presented here may be used for comparison with other geomechanical/ porous-flow simulators.