University of Texas System

About: University of Texas System is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 13901 authors who have published 10925 publications receiving 319328 citations. The organization is also known as: UT System.

Management with chemotherapy only of stage I and II malignant lymphoma of aggressive histologic types.

Abstract: Thirty patients with clinical stage I-II malignant lymphoma of aggressive histologic types (histiocytic, undifferentiated, and mixed) were treated with chemotherapy alone. Of 25 patients with measurable disease, 22 (88%) achieved a complete remission. The remaining five patients had been rendered disease-free at the time of excisional biopsy; for this reason, they are considered evaluable only for duration of disease-free survival. Of the 27 patients who achieved disease-free status, 23 (85%) remain free of any evidence of disease. All eight patients with stage I disease and 15 of the 19 patients with stage II disease remain free of disease. The use of clinical instead of surgical staging, followed promptly by systemic treatment with combination chemotherapy, results in a substantial cure rate and avoids the undesirable morbidity and treatment delay associated with laparotomy. The results of this approach compare favorably with those obtained by radiotherapy alone or with combined radiation and chemotherapy for surgically staged patients.

Release of Newly Synthesized Dopamine into the Hypophysial Portal Vasculature of the Rat

Abstract: . The concentrations of dopamine and norepinephrine in pituitary stalk and arterial plasma from rats were determined after the administration of pharmacological agents known to influence neurotransmission in dopaminergic neurons of the brain and to alter the release of PRL from the anterior pituitarygland. The concentrations of dopamine and norepinephrine in pituitary stalk plasma from male rats were markedly elevated after an infusion of rf-amphetamine (5.0 mg/kg, iv). In addition, the arterial plasma concentrations of norepinephrine, but not dopamine, were also elevated in these animals. In male rats which had been pretreated with α-methyltyrosine (50 mg/kg, iv), amphetamine was ineffective in elevating the concentration of dopamine in stalk plasma but was effective in increasing the concentration of norepinephrine in pituitary stalk and arterial plasma. Although reserpine treatment led to a 95% reduction in the dopamine content of the median eminence and a reduction in catecholamine concentrati...

Role of the C-10 Substituent in Mitomycin C-1−DNA Bonding

Abstract: The structural requirements for mitomycin C-1 bonding have been investigated by comparing the bonding specificity of mitomycin C (1) with selectively modified porfiromycins (N-methylmitomycin C) at the C-10 position under reductive conditions and then comparing N-methyl-7-methoxyaziridinomitosene (10) with 7-methoxy-10-noraziridinomitosene (11) under nonreductive conditions. Enzymatic and chemical reductive activation of mitomycin C in the presence of the 129-bp fragment from pBR322 led to exclusive guanine (G*) modification with drug bonding that occurred preferentially at 5‘CG* sites, while C-10 chloro (8) and C-10 bromo (9) deoxycarbamoylporfiromycins modified DNA at guanines but with significantly diminished 5‘CG* sequence selectivity. A similar set of bonding profiles were observed with 10 and 11 upon incubation with DNA. Mitosene 10 selectively modified 5‘CG* sites in DNA, while 11 did not. These studies provided support for the hypothesis that a hydrogen bond between the C-10 oxygen in the activate...