Institution
University of Texas System
Education•Austin, Texas, United States•
About: University of Texas System is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 13901 authors who have published 10925 publications receiving 319328 citations. The organization is also known as: UT System.
Topics: Cancer, Population, Antigen, Gene, Antibody
Papers published on a yearly basis
Papers
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18 Nov 1993TL;DR: In this article, the authors describe methods of producing recombinant polypeptides in protease-deficient bacterial hosts. But they do not consider the use of recombinant proteins in E. coli, and their methods are limited to single, double, triple, quadruple, and quadruple protease deficient and protease/rpoH mutants.
Abstract: The invention relates to methods of producing recombinant polypeptides in protease-deficient bacterial hosts. Constructs of single, double, triple and quadruple protease deficient and protease/rpoH mutants of E. coli are described. Proteolytically sensitive polypeptides may be expressed and secreted in such cells, providing significantly increased yields compared with expression in wild-type strains.
132 citations
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TL;DR: It is concluded that many patients with longstanding insulin-dependent diabetes have (a) reduced acid secretory responses to sham feeding, suggesting vagal neuropathy; (b) normal acid secretORY responses to infused food, despite an enhanced serum gastrin response; and (c) delayed gastric emptying.
132 citations
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TL;DR: The lymphocytes in the blood samples collected at 1 and 2 h after melatonin ingestion and exposed in vitro to 150 cGy gamma radiation exhibited a significant decrease in the incidence of chromosome aberrations and micronuclei, as compared with similarly irradiated lymphocytes from the blood sample collected at 0 h.
Abstract: Peripheral blood samples were collected from human volunteers at 0 (5–10 min before), and at 1 and 2 h after a single oral dose of 300 mg of melatonin. At each time point, (i) the concentration of melatonin in the serum and in the leukocytes were cultured with mitogenic stimulation to determine the extent of radiation-induced genetic damage, viz., chromosome aberrations and micronuclei. For each volunteer, the results showed a significant increase in the concentration of melatonin in the serum and in the leukocytes at 1 h after the oral dose of melatonin, as compared to the sample collected at 0 h. The lymphocytes in the blood samples collected at 1 and 2 h after melatonin ingestion and exposed in vitro to 150 cGy gamma radiation exhibited a significant decrease in the incidence of chromosome aberrations and micronuclei, as compared with similarly irradiated lymphocytes from the blood sample collected at 0 h; the frequencies abserved in the cells sampled at 2 h after the ingestion of melatonin were consistently lower when compared with those collected at 1 h. The data may have important implications for the protection of human lymphocytes from the genetic damage induced by free radical-producing mutagens and carcinogens.
131 citations
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TL;DR: The morphology and distribution of vasoactive intestinal polypeptide-like immunoreactive neurons in the visual cortex of albino rats whose ages were closely spaced in time between the first postnatal day and adulthood were examined using immunocytochemistry.
Abstract: Using immunocytochemistry, we have examined the morphology and distribution of vasoactive intestinal polypeptide-like immunoreactive neurons in the visual cortex of albino rats whose ages were closely spaced in time between the first postnatal day and adulthood. In the adult, immunoreactive neurons were located in layers II to VI but were concentrated in layers II and III. All labelled neurons had the morphological characteristics of cortical non-pyramidal cells with the majority being of the bipolar variety as described in Golgi preparations. Some multipolar forms were also present.
131 citations
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TL;DR: Although HAART significantly reduces HIV viral load, the entire T-cell repertoire and immune function may not be completely restored, and clinically significant immune deficiency is not necessary for the induction of KSHV-related malignancy.
Abstract: Discovered in 1994, Kaposi’s sarcoma-associated herpesvirus (KSHV) has been associated with four human malignancies including Kaposi’s sarcoma, primary effusion lymphoma, a subset of multicentric Castleman’s disease, and KSHV inflammatory cytokine syndrome. These malignancies mostly occur in immunocompromised patients including patients with acquired immunodeficiency syndrome and often cause significant mortality because of the lack of effective therapies. Significant progresses have been made to understand the molecular basis of KSHV infection and KSHV-induced oncogenesis in the last two decades. This chapter provides an update on the recent advancements focusing on the molecular events of KSHV primary infection, the mechanisms regulating KSHV life cycle, innate and adaptive immunity, mechanism of KSHV-induced tumorigenesis and inflammation, and metabolic reprogramming in KSHV infection and KSHV-transformed cells.
131 citations
Authors
Showing all 13902 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Joseph L. Goldstein | 207 | 556 | 149527 |
Eric N. Olson | 206 | 814 | 144586 |
Hagop M. Kantarjian | 204 | 3708 | 210208 |
Thomas C. Südhof | 191 | 653 | 118007 |
Gordon B. Mills | 187 | 1273 | 186451 |
Michael S. Brown | 185 | 422 | 123723 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Russel J. Reiter | 169 | 1646 | 121010 |
John D. Minna | 169 | 951 | 106363 |
Timothy A. Springer | 167 | 669 | 122421 |
Gabriel N. Hortobagyi | 166 | 1374 | 104845 |
Rodney S. Ruoff | 164 | 666 | 194902 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Ronald A. DePinho | 160 | 486 | 104039 |