Institution
University of Texas System
Education•Austin, Texas, United States•
About: University of Texas System is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 13901 authors who have published 10925 publications receiving 319328 citations. The organization is also known as: UT System.
Topics: Cancer, Population, Antigen, Gene, Antibody
Papers published on a yearly basis
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TL;DR: Potential regulatory mechanisms in CL synthesis and the effects of de-acylation pathways on steady state levels of CL and its interaction with cytochrome c are described and the model of fatty acid induced apoptosis is used as a paradigm to understanding of the temporal relationship between decreased mitochondrial CL, release of cy tochrome c, and initiation of apoptosis.
263 citations
Patent•
11 Oct 2000TL;DR: In this article, a method for regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract is presented.
Abstract: The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract. The invention is further directed to a method for reducing weight in a subject, again using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the stomach. The invention is further directed to a method of providing electrical field stimulation to a gastrointestinal organ, as well as a method of providing an electrical potential gradient in a gastrointestinal organ. Further provided is a method of stimulating the vagus nerve of a subject. Additionally provided is a method of placing a device in the gastrointestinal tract or wall of a subject from the exterior of the subject, using a needle to insert the device.
263 citations
TL;DR: Complementation analyses show that Lec2 mutants belong to the same genetic complementation group as clone 1021, a CHO mutant of similar phenotype, and it seems likely that the primary defect in Lec1 and 1021 cells is their inability to translocate CMP-sialic acid across Golgi vesicle membranes.
262 citations
TL;DR: General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances and it is shown that the contribution of F is as important as that of C and G.
262 citations
TL;DR: It is indicated that taxol differentially modulates microtubule dynamics depending upon the beta-tubulin isotype composition, which is consistent with recent studies correlating taxol resistance in tumor cells with increased levels of beta(III0- and beta(IV)-tubulin expression and suggest that altered cellular expression of beta- Tubulin isotypes can be an important mechanism by which tumor cells develop resistance to taxol.
Abstract: Substoichiometric binding of taxol to tubulin in microtubules potently suppresses microtubule dynamics, which appears to be the most sensitive antiproliferative mechanism of taxol. To determine whether the β-tubulin isotype composition of a microtubule can modulate sensitivity to taxol, we measured the effects of substoichiometric ratios of taxol bound to tubulin in microtubules on the dynamics of microtubules composed of purified αβII-, αβIII-, or αβIV-tubulin isotypes and compared the results with the effects of taxol on microtubules assembled from unfractionated tubulin. Substoichiometric ratios of bound taxol in microtubules assembled from purified β-tubulin isotypes or unfractionated tubulin potently suppressed the shortening rates and the lengths shortened per shortening event. Correlation of the suppression of the shortening rate with the stoichiometry of bound taxol revealed that microtubules composed of purified αβII-, αβIII-, and αβIV-tubulin were, respectively, 1.6-, 7.4-, and 7.2-fold less sen...
261 citations
Authors
Showing all 13902 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Yi Chen | 217 | 4342 | 293080 |
| Joseph L. Goldstein | 207 | 556 | 149527 |
| Eric N. Olson | 206 | 814 | 144586 |
| Hagop M. Kantarjian | 204 | 3708 | 210208 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Gordon B. Mills | 187 | 1273 | 186451 |
| Michael S. Brown | 185 | 422 | 123723 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Russel J. Reiter | 169 | 1646 | 121010 |
| John D. Minna | 169 | 951 | 106363 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Gabriel N. Hortobagyi | 166 | 1374 | 104845 |
| Rodney S. Ruoff | 164 | 666 | 194902 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Ronald A. DePinho | 160 | 486 | 104039 |