Institution
Walter and Eliza Hall Institute of Medical Research
Nonprofit•Melbourne, Victoria, Australia•
About: Walter and Eliza Hall Institute of Medical Research is a nonprofit organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Antigen & Immune system. The organization has 5012 authors who have published 10620 publications receiving 873561 citations.
Topics: Antigen, Immune system, Population, T cell, Plasmodium falciparum
Papers published on a yearly basis
Papers
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TL;DR: This novel combination of venetoclax with bortezomib and dexamethasone has an acceptable safety profile and promising efficacy in patients with relapsed/refractory MM.
213 citations
TL;DR: This genetic analysis provides physiological evidence of cross-talk between GTPase proteins and suggests that a balance of these two GTPases controls HSC/P adhesion and mobilization in vivo.
Abstract: Critical to homeostasis of blood cell production by hematopoietic stem/progenitor (HSC/P) cells is the regulation of HSC/P retention within the bone marrow microenvironment and migration between the bone marrow and the blood. Key extracellular regulatory elements for this process have been defined (cell-cell adhesion, growth factors, chemokines), but the mechanism by which HSC/P cells reconcile multiple external signals has not been elucidated. Rac and related small GTPases are candidates for this role and were studied in HSC/P deficient in Rac2, a hematopoietic cell-specific family member. Rac2 appears to be critical for HSC/P adhesion both in vitro and in vivo, whereas a compensatory increase in Cdc42 activation regulates HSC/P migration. This genetic analysis provides physiological evidence of cross-talk between GTPase proteins and suggests that a balance of these two GTPases controls HSC/P adhesion and mobilization in vivo.
213 citations
TL;DR: It is concluded that in both primates and model organisms, stabilizing selection is likely to be the dominant mode of gene expression evolution, and mutations affecting gene expression will often be deleterious and might underlie many human diseases.
213 citations
TL;DR: It is demonstrated that the tight-junction components claudin-3 and claud in-4 were 'preferentially' expressed in Aire+ mTECs, suggesting that Aire+, mTecs represent terminally differentiated cells in a unique lineage arising during thymic organogenesis.
Abstract: Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin
212 citations
TL;DR: The latest in the understanding of the molecular composition of this highly complex and fascinating biological process of Plasmodium species cause malaria is reviewed.
212 citations
Authors
Showing all 5041 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Martin White | 196 | 2038 | 232387 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Tien Yin Wong | 160 | 1880 | 131830 |
| Mark J. Smyth | 153 | 713 | 88783 |
| Anne B. Newman | 150 | 902 | 99255 |
| James P. Allison | 137 | 483 | 83336 |
| Scott W. Lowe | 134 | 396 | 89376 |
| Rajkumar Buyya | 133 | 1066 | 95164 |
| Peter Hall | 132 | 1640 | 85019 |
| Ralph L. Brinster | 131 | 382 | 56455 |
| Nico van Rooijen | 130 | 513 | 62623 |
| David A. Hafler | 128 | 558 | 64314 |
| Andreas Strasser | 128 | 509 | 66903 |
| Marc Feldmann | 125 | 663 | 64916 |
| Herman Waldmann | 118 | 586 | 49942 |