Institution
Walter and Eliza Hall Institute of Medical Research
Nonprofit•Melbourne, Victoria, Australia•
About: Walter and Eliza Hall Institute of Medical Research is a nonprofit organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Antigen & Immune system. The organization has 5012 authors who have published 10620 publications receiving 873561 citations.
Topics: Antigen, Immune system, Population, T cell, Plasmodium falciparum
Papers published on a yearly basis
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TL;DR: It is shown that female mice with a null mutation of the interleukin-11 receptor alpha chain are infertile because of defective decidualization, revealing a previously unrecognized critical role for IL-11 signaling in female reproduction.
Abstract: During early pregnancy, in response to the implanting embryo, the surrounding uterine stroma undergoes a dramatic transformation into a specialized tissue known as the decidua. The de-cidua encapsulates the developing embryo, facilitating nutrient transfer and limiting tro-phoblast invasion. Here we show that female mice with a null mutation of the interleukin-11 receptor alpha chain are infertile because of defective decidualization. A temporal analysis revealed IL-11 expression is maximal in the normal pregnant uterus at the time of decidualization, and in situ hybridization studies showed expression of the IL-11 and the IL-11 receptor alpha chain in the developing decidual cells. These observations reveal a previously unrecognized critical role for IL-11 signaling in female reproduction.
455 citations
TL;DR: Members of the tumour necrosis factor receptor family that contain a death domain have pleiotropic activities and signalling through FADD/MORT1 does not lead exclusively to cell death, but under certain circumstances can promote cell survival and proliferation.
Abstract: Members of the tumour necrosis factor receptor family that contain a death domain have pleiotropic activities. They induce apoptosis via interaction with intracellular FADD/MORT1 and trigger cell growth or differentiation via TRADD and TRAF molecules. The impact of FADD/MORT1-transduced signals on T lymphocyte development was investigated in transgenic mice expressing a dominant negative mutant protein, FADD-DN. Unexpectedly, FADD-DN enhanced negative selection of self-reactive thymic lymphocytes and inhibited T cell activation by increasing apoptosis. Thus signalling through FADD/MORT1 does not lead exclusively to cell death, but under certain circumstances can promote cell survival and proliferation.
453 citations
Naturalis1, University of Helsinki2, American Museum of Natural History3, University of Copenhagen4, Institut national de la recherche agronomique5, Centre national de la recherche scientifique6, University of Maryland, College Park7, University of Oulu8, University of Turku9, National Sun Yat-sen University10, National Museum of Natural History11, University of Valencia12, Smithsonian Institution13, Sam Houston State University14, Royal Museum for Central Africa15, California Department of Food and Agriculture16, Walter and Eliza Hall Institute of Medical Research17, Florida Museum of Natural History18, Agriculture and Agri-Food Canada19, National University of San Marcos20, Mississippi State University21, University of New Orleans22, Canadian Food Inspection Agency23
TL;DR: This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
Abstract: van Nieukerken, Erik J.; Kaila, Lauri; Kitching, Ian J.; Kristensen, Niels Peder; Lees, David C.; Minet, Joël; Mitter, Charles; Mutanen, Marko; Regier, Jerome C.; Simonsen, Thomas J.; Wahlberg, Niklas; Yen, Shen-Horn; Zahiri, Reza; Adamski, David; Baixeras, Joaquin; Bartsch, Daniel; Bengtsson, Bengt Å.; Brown, John W.; Bucheli, Sibyl Rae; Davis, Donald R.; de Prins, Jurate; de Prins, Willy; Epstein, Marc E.; Gentili-Poole, Patricia; Gielis, Caes; Hättenschwiler, Peter; Hausmann, Axel; Holloway, Jeremy D.; Kallies, Axel; Karsholt, Ole; Kawahara, Akito Y.; Koster, Sjaak; Kozlov, Mikhail; Lafontaine, J. Donald; Lamas, Gerardo; Landry, JeanFrançois; Lee, Sangmi; Nuss, Matthias; Park, Kyu-Tek; Penz, Carla; Rota, Jadranka; Schintlmeister, Alexander; Schmidt, B. Christian; Sohn, Jae-Cheon; Solis, M. Alma; Tarmann, Gerhard M.; Warren, Andrew D.; Weller, Susan; Yakovlev, Roman V.; Zolotuhin, Vadim V.; Zwick, Andreas
450 citations
TL;DR: Knobs at the surface of erythrocytes infected with Plasmodium falciparum have been proposed to be important in adherence of these cells to the vascular endothelium, but the gene encoding KAHRP is disrupted and it is shown that it is essential for knob formation.
450 citations
TL;DR: Three families of proteins, the SH2-containing phosphatases (SHP), the protein inhibitors of activated STATs (PIAS), and the suppressors of cytokine signaling (SOCS), inhibit specific and distinct aspects of cytokines signal transduction.
449 citations
Authors
Showing all 5041 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Martin White | 196 | 2038 | 232387 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Tien Yin Wong | 160 | 1880 | 131830 |
| Mark J. Smyth | 153 | 713 | 88783 |
| Anne B. Newman | 150 | 902 | 99255 |
| James P. Allison | 137 | 483 | 83336 |
| Scott W. Lowe | 134 | 396 | 89376 |
| Rajkumar Buyya | 133 | 1066 | 95164 |
| Peter Hall | 132 | 1640 | 85019 |
| Ralph L. Brinster | 131 | 382 | 56455 |
| Nico van Rooijen | 130 | 513 | 62623 |
| David A. Hafler | 128 | 558 | 64314 |
| Andreas Strasser | 128 | 509 | 66903 |
| Marc Feldmann | 125 | 663 | 64916 |
| Herman Waldmann | 118 | 586 | 49942 |