Yanshan University

About: Yanshan University is a education organization based out in Qinhuangdao, China. It is known for research contribution in the topics: Microstructure & Control theory. The organization has 19544 authors who have published 16904 publications receiving 184378 citations. The organization is also known as: Yānshān dàxué.

Smart Collaborative Balancing for Dependable Network Components in Cyber-Physical Systems

Abstract: The evolution of cyber–physical system (CPS) benefits from substantial supports of many cutting-edge technologies. However, as a significant medium to bridge virtual and reality parts, the dependability of various network components is facing unprecedented challenges and threats. In this article, we propose a smart collaborative balancing (SCB) scheme to dynamically adjust the orchestration of network functions and efficiently optimize the workflow patterns. First, mathematical models of bandwidth allocation for multiuser with appropriate probability distribution are established. Matrix operations are utilized to solve the relevant issues based on individual congestion windows. Invasion defense mechanisms are also provided and discussed. Second, specific procedures of collaboration among different network components are presented. The capabilities of CPS, in terms of bandwidth allocation and invasion defense, are guaranteed via novel queueing policies and access control mechanisms. Third, we build a comprehensive prototype including multiple domains and users for validations. Experimental results in two scenarios illustrate that SCB not only supports service reliability of end hosts with different priorities, but also resists malicious attacks which are targeting the corresponding terminals inside domains. Compared to the benchmarks in software defined networks and traditional Internet, our scheme performs better in both available resource management and abnormal flow recognition aspects.

Oleanolic acid liposomes with polyethylene glycol modification: promising antitumor drug delivery.

Abstract: Background Oleanolic acid is a pentacyclic triterpene present in many fruits and vegetables, and has received much attention on account of its biological properties. However, its poor solubility and low bioavailability limit its use. The objective of this study was to encapsulate oleanolic acid into nanoliposomes using the modified ethanol injection method. Methods The liposomes contain a hydrophobic oleanolic acid core, an amphiphilic soybean lecithin monolayer, and a protective hydrophilic polyethylene glycol (PEG) coating. During the preparation process, the formulations described were investigated by designing 3⁴ orthogonal experiments as well as considering the effects of different physical characteristics. The four factors were the ratios of drug to soybean phosphatidylcholine (w/w), cholesterol (w/w), PEG-2000 (w/w), and temperature of phosphate-buffered saline at three different levels. We identified the optimized formulation which showed the most satisfactory lipid stability and particle formation. The morphology of the liposomes obtained was determined by transmission electron microscopy and atomic force microscopy. The existence of PEG in the liposome component was validated by Fourier transform infrared spectrum analysis. Results The PEGylated liposomes dispersed individually and had diameters of around 110-200 nm. Encapsulation efficiency was more than 85%, as calculated by high-performance liquid chromatography and Sephadex® gel filtration. Furthermore, when compared with native oleanolic acid, the liposomal formulations showed better stability in vitro. Finally, the cytotoxicity of the oleanolic acid liposomes was evaluated using a microtiter tetrazolium assay. Conclusion These results suggest that PEGylated liposomes would serve as a potent delivery vehicle for oleanolic acid in future cancer therapy.