Journal ArticleDOI
Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience.
Dandan Wang,Huayong Zhang,Jun Liang,Xia Li,Xuebing Feng,Hong Wang,Bingzhu Hua,Bujun Liu,Liwei Lu,Gary S. Gilkeson,Richard M. Silver,Wanjun Chen,Songtao Shi,Lingyun Sun +13 more
TLDR
Allogeneic MSCT resulted in the induction of clinical remission and improvement in organ dysfunction in drug-resistant SLE patients, and disease activity declined as revealed by significant changes in the SLEDAI score, levels of serum autoantibodies, albumin, and complements.About:
This article is published in Cell Transplantation.The article was published on 2013-12-01. It has received 229 citations till now. The article focuses on the topics: Transplantation.read more
Citations
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Clinical Trials with Mesenchymal Stem Cells: An Update:
TL;DR: Clinical trials using MSCs for representative diseases, including hematological disease, graft-versus-host disease, organ transplantation, diabetes, inflammatory diseases, and diseases in the liver, kidney, and lung are analyzed, as well as cardiovascular, bone and cartilage, neurological, and autoimmune diseases.
Journal ArticleDOI
Mesenchymal stem cells and immunomodulation: current status and future prospects
Fei Gao,Sm M. Chiu,Dal A. L. Motan,Zhao Zhang,L. Chen,Hong-Lin Ji,Hf-F. Tse,Qinf-Ling Fu,Qizhou Lian +8 more
TL;DR: The preclinical and clinical studies of MSCs from different adult tissues are summarized, the current hurdles to their use are discussed, and the future development of pluripotent stem cell-derived M SCs are proposed as an approach to immunomodulation therapy.
Journal ArticleDOI
Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial.
Aurelio Vega,Miguel Ángel Martín-Ferrero,Francisco Del Canto,Mercedes Alberca,Verónica García,Anna Munar,Lluis Orozco,Robert Soler,Juan Jose Fuertes,Marina Huguet,Ana Sánchez,Javier García-Sancho +11 more
TL;DR: Allogeneic MSC therapy may be a valid alternative for the treatment of chronic knee osteoarthritis that is more logistically convenient than autologous MSC treatment and significantly improves cartilage quality.
Journal ArticleDOI
Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications.
TL;DR: The effects of MSCs on T cells, principal effectors of the immune response, and the immunosuppressive effects mediated by the secretion of soluble factors and membrane molecules are emphasized.
Journal ArticleDOI
Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
TL;DR: Though immunotherapy of MSCs remains controversial, these clinical trials pave the way for their widespread therapeutic application in immune-based diseases, and the latest research findings and clinical trials on MSC-based immunomodulation are updated.
References
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Journal ArticleDOI
Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE.
TL;DR: The development of the SLEDAI is described, a validated model of experienced clinicians' global assessments of disease activity in lupus, which represents the consensus of a group of experts in the field of l upus research.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study.
Katarina Le Blanc,Francesco Frassoni,Lynne M. Ball,Franco Locatelli,Helene Roelofs,Ian D. Lewis,Edoardo Lanino,Berit Sundberg,Maria Ester Bernardo,Mats Remberger,Giorgio Dini,R. Maarten Egeler,Andrea Bacigalupo,Willem E. Fibbe,Olle Ringdén +14 more
TL;DR: Infusion of mesenchymal stem cells expanded in vitro, irrespective of the donor, might be an effective therapy for patients with steroid-resistant, acute GVHD.
Journal ArticleDOI
Adult bone marrow stromal cells differentiate into neural cells in vitro.
Juan Sanchez-Ramos,Shijie Song,Fernando Cardozo-Pelaez,C. Hazzi,Todd Stedeford,Alison E. Willing,Thomas B. Freeman,Samuel Saporta,William J. Janssen,Niketa A. Patel,Denise R. Cooper,Paul R. Sanberg +11 more
TL;DR: It is demonstrated that human and mouse BMSC can be induced to differentiate into neural cells under experimental cell culture conditions.
Journal ArticleDOI
Immunomodulatory properties of mesenchymal stromal cells.
Alma J. Nauta,Willem E. Fibbe +1 more
TL;DR: The aim of this review is to critically discuss the immunogenicity and immunomodulatory properties of MSCs, both in vitro and in vivo, the possible underlying mechanisms, the potential clinical use of M SCs as modulators of immune responses in vivo and to indicate clinical safety concerns and recommendations for future research.