Showing papers in "Cellular Signalling in 2019"

TL;DR: Interleukin-1 signaling (IL-1) plays a central role and its effects on the different cell types involved in OA are discussed in this review with a special focus on the chondrocyte.

TL;DR: It is proposed that two forms of the ligand binding two receptors and activating two signaling pathways enables fine-tuned neutrophil function compared to a single form, a single receptor, or a single pathway.

TL;DR: D-dopachrome tautomerase (D-DT or MIF-2) was recognized to be a structural and functional homolog of MIF, which could exert overlapping effects, raising further the complexity of canonical MIF signaling pathways.

TL;DR: This review aims to provide recent advances in the importance of hyaluronan-CD44 interactions in the acquisition and maintenance of a CSC phenotype through induction of EMT program, oxidative stress resistance, secretion of extracellular vesicles/exosomes and epigenetic control.

TL;DR: An overview of TGFβ signalling in SMCs is presented, highlighting the ways in which this multifaceted cytokine regulates SMC behaviour and phenotype in cardiovascular diseases driven by intimal hyperplasia.

TL;DR: The antiarthritic effects of AMG487 are demonstrated in CIA animal model and the development of CXCR3 antagonists as a novel strategy for the treatment of inflammatory and arthritic conditions are supported.

TL;DR: It is observed that erastin suppressed the malignant phenotypes of liver cancer cells by inhibiting O-GlcNAcylation of c-Jun and further inhibited protein expression, transcription activity and nuclear accumulation of c.Jun.

TL;DR: Recent understandings on the roles of HSPG in cytokine stimulated cellular signaling are discussed, focusing on FGF, TGF-β, Wnt, Hh, HGF and VEGF.

TL;DR: A role for FABPs is increasingly being reported in tumor biology with elevated exogenous FABP expression being associated with tumor progression and invasiveness, however, a less clear role has been appreciated for dysregulated FABp expression during cell transformation and early expansion.

TL;DR: The results indicate that Sirt3 enhancement could be an effective approach to retard the development of post-infarction cardiac injury via disrupting mitochondrial fission and normalizing the AMPK-Drp1 axis.

TL;DR: It is suggested that lactate accelerates osteoblastic phenotype transition of VSMC and calcium deposition partly through the BNIP3-mediated mitophagy deficiency induced oxidative stress and apoptosis.

TL;DR: This is the first study to report that SLFN5 inhibits cancer migration and invasiveness in several common cancer cell lines by repressing MT1-MMP expression via the AKT/GSK-3β/β-catenin signalling pathway, suggesting that SL FN5 plays wide inhibitory roles in various cancers.

TL;DR: A novel mechanism of cZNF292 is delineated in enhancing hypoxic tumor cell radiosensitivity, which might provide valuable targets for radiation therapy for hepatoma.

TL;DR: It is demonstrated that decreased lncRNA LINC00667 could promote renal tubular epithelial cell proliferation and ameliorate renal fibrosis in CRF via the miR-19b-3p/LINC 00667/connective tissue growth factor (CTGF) signaling pathway.

TL;DR: It is shown that Cd induced significant increases in autophagosomes with a concomitant elevation of LC3-II and p62 in PC12 cells and primary neurons and activation of Akt functioned in impairing autophagic flux, and that inhibition of AkT to improve autophagy flux is a promising strategy against Cd-induced neurotoxicity and neurodegeneration.

TL;DR: This study strongly suggests the adverse effect of AREG in PM-induced inflammation and mucus hypersecretion via the EGFR-PI3Kα-AKT/ERK pathway and contributes to a better understanding of the biological mechanisms underlying exacerbation of chronic respiratory diseases induced by PM exposure.

TL;DR: It is demonstrated that SREBP-1 could be a key player in oxLDL-induced excessive lipid accumulation leading to macrophage FCF via ROS-mediated NLRP3/IL-1β/SRE BP-1 pathway.

TL;DR: Investigation of the effect of MALAT1 on the proliferation, migration, and drug sensitivity of CRC cells in vitro and in vivo and the mechanisms involved therein suggests the interaction between MALat1 and miR-20b-5p could be a novel therapeutic target for CRC.

TL;DR: The findings suggest the protective effect of JTE013 on brain endothelial barrier integrity is likely mediated by suppressing p38 and Erk1/2-dependent cPLA2 phosphorylation under oxidative stress.

TL;DR: SFKs associate with prognosis and the local inflammatory response in patients with stage I-III CRC and active membrane FGR and HCK work in parallel to promote tumour progression and down-regulation of the localinflammatory lymphocytic response.

TL;DR: LXA4 may ameliorate vascular endothelial cell oxidative stress injury and subsequent thrombotic response via LXA4 receptor-dependent activation of the Nrf2-HO-1 signaling, implying a promising strategy for DVT and its complication.

TL;DR: The central role of Fra-2 connecting inflammation, cellular proliferation and extracellular matrix deposition underlying chronic lung diseases and what the authors can learn for future therapeutic options are discussed.

TL;DR: Light is shone on the interplay between IL-18 and IL-22 and their opponents in order to provide integrated information on their biology, pathophysiological significance, and prospect as targets and/or instruments of therapeutic intervention.

TL;DR: It is shown that NanoBRET ligand binding assays can be performed at gene-edited receptors under endogenous promotion in live cells, therefore overcoming a fundamental limitation of NanoBret ligand assays.

TL;DR: AKT2 increases the invasion, tumorigenesis, and metastasis of colon cancer cells in vitro and promotes lung metastasis in nude mice in vivo through the phosphorylation of the T473 site of HK2 by upregulating NF-κB, HIF1α, MMP2, and MMP9.

TL;DR: Overall, this study indicated that radiation specifically triggered the intrinsic apoptotic signaling pathway through Bcl-2 family protein-dependent mitochondrial permeabilization, which indicates targeting mitochondria is a promising strategy for cancer radiotherapy.

TL;DR: The role of ER stress in hyperglycemia induced gluco-metabolic aberrations and liver injury as confirmed by ISRIB, a standard chemical ER stress inhibitor is affirm.

TL;DR: It is shown that autophagy negatively regulates Wnt/β-catenin signalling in glioblastoma multiforme (GBM) cells, through Dishevelled degradation, and the first evidence is provided thatAutophagy promotes β- catenin relocalisation within the cell, by inducing a decrease of the nuclear protein fraction.

TL;DR: It is reported that USF2 (upstream stimulatory factor 2), a basic helix-loop-helix-leucine-zip transcription factor, is necessary for the transcriptional activity of Smurf1 and SmurF2 and shed new light on the cancer-promoting role of USF 2.

TL;DR: These studies indicate that identifying potential miRNAs (including hsa-miR-19a-5p) as therapeutic targets for inhibiting angiogenesis and tumor progression will require this type of physiologically relevant analysis.