1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells.
Guido Heine,Uwe Niesner,Hyun-Dong Chang,Andreas Steinmeyer,Ulrich Zügel,Torsten Zuberbier,Andreas Radbruch,Margitta Worm +7 more
TLDR
It is reported here that activation of human B cells by B cell receptor, CD40 and IL‐4 signals induces expression of the gene for 25‐hydroxyvitamin‐D3–1α‐hydroxylase (CYP1α), and their ability to produce calcitriol from its precursor, suggest that pro‐vitamin D (25‐Hydroxyv vitamin D3) can be used as a modulator of allergic immune responses.Abstract:
1,25-dihydroxyvitamin D(3) (calcitriol) regulates immune responses, e.g., inhibits expression of IgE by B cells and enhances expression of IL-10 by dendritic cells and T cells. We report here that activation of human B cells by B cell receptor, CD40 and IL-4 signals induces expression of the gene for 25-hydroxyvitamin-D3-1alpha-hydroxylase (CYP1alpha). Accordingly, these B cells generate and secrete significant amounts of calcitriol. In activated B cells calcitriol induces expression of the genes Cyp24, encoding a vitamin D hydroxylase, and Trpv6, encoding a calcium selective channel protein. Calcitriol enhances IL-10 expression of activated B cells more than threefold, both by recruiting the vitamin D receptor to the promoter of Il-10, and to lesser extent by modulation of calcium-dependent signaling. The molecular link in activated B cells between vitamin D signaling, expression of IgE and IL-10, and their ability to produce calcitriol from its precursor, suggest that pro-vitamin D (25-hydroxyvitamin D(3)) can be used as a modulator of allergic immune responses.read more
Citations
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Journal ArticleDOI
The regulation of IL-10 production by immune cells
Margarida Saraiva,Anne O'Garra +1 more
TL;DR: Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.
Journal ArticleDOI
Vitamin D: modulator of the immune system.
TL;DR: 1,25(OH)(2)D(3) is described as an immunomodulator targeting various immune cells, including monocytes, macrophages, dendritic cells (DCs), as well as T-lymphocytes and B-LYmphocytes, hence modulating both innate and adaptive immune responses.
Journal ArticleDOI
Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease
Shankar S. Iyer,Genhong Cheng +1 more
TL;DR: M modes of regulation of IL-10 gene expression in immune effector cell types are discussed, including signal transduction, epigenetics, promoter architecture, and post-transcriptional regulation, and how aberrant regulation contributes to immunopathology and disease progression.
Journal ArticleDOI
An update on vitamin D and human immunity.
TL;DR: The conclusion from these reports is that many nonclassical actions of vitamin D are independent of conventional vitamin D endocrinology and are therefore more sensitive to variations in vitamin D status.
Journal ArticleDOI
Immunologic Effects of Vitamin D on Human Health and Disease
TL;DR: It is advisable to increase vitamin D intake and have sensible sunlight exposure to maintain serum 25-hydroxyvitamin D at least 30 ng/L, and preferably at 40–60 ng/mL (100–150 nmol/L) to achieve the optimal overall health benefits of vitamin D.
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