23Na Magnetic Resonance Imaging-Determined Tissue Sodium in Healthy Subjects and Hypertensive Patients
Christoph W. Kopp,Peter Linz,Anke Dahlmann,Matthias Hammon,Jonathan Jantsch,Dominik N. Müller,Roland E. Schmieder,Alexander Cavallaro,Kai-Uwe Eckardt,Michael Uder,Friedrich C. Luft,Jens Titze +11 more
TLDR
23Na magnetic resonance imaging could have utility in assessing the role of tissue Na+ storage for cardiovascular morbidity and mortality in longitudinal studies, and it is suggested that patients with refractory hypertension had increased tissueNa+ content, compared with normotensive controls.Abstract:
High dietary salt intake is associated with hypertension; the prevalence of salt-sensitive hypertension increases with age. We hypothesized that tissue Na(+) might accumulate in hypertensive patients and that aging might be accompanied by Na(+) deposition in tissue. We implemented (23)Na magnetic resonance imaging to measure Na(+) content of soft tissues in vivo earlier, but had not studied essential hypertension. We report on a cohort of 56 healthy control men and women, and 57 men and women with essential hypertension. The ages ranged from 22 to 90 years. (23)Na magnetic resonance imaging measurements were made at the level of the calf. We observed age-dependent increases in Na(+) content in muscle in men, whereas muscle Na(+) content did not change with age in women. We estimated water content with conventional MRI and found no age-related increases in muscle water in men, despite remarkable Na(+) accumulation, indicating water-free Na(+) storage in muscle. With increasing age, there was Na(+) deposition in the skin in both women and men; however, skin Na(+) content remained lower in women. Similarly, this sex difference was found in skin water content, which was lower in women than in men. In contrast to muscle, increasing Na(+) content was paralleled with increasing skin water content. When controlled for age, we found that patients with refractory hypertension had increased tissue Na(+) content, compared with normotensive controls. These observations suggest that (23)Na magnetic resonance imaging could have utility in assessing the role of tissue Na(+) storage for cardiovascular morbidity and mortality in longitudinal studies.read more
Citations
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Journal ArticleDOI
Sodium MRI: Methods and applications
TL;DR: An up-to-date review of the theoretical background, the methodology, the challenges, limitations, and current and potential new applications of sodium MRI is presented.
Journal ArticleDOI
Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD.
Markus P. Schneider,Ulrike Raff,Christoph W. Kopp,Johannes B. Scheppach,Sebastian Toncar,Christoph Wanner,Georg Schlieper,Turgay Saritas,Jürgen Floege,Matthias Schmid,Anna Birukov,Anke Dahlmann,Peter Linz,Rolf Janka,Michael Uder,Roland E. Schmieder,Jens Titze,Kai-Uwe Eckardt +17 more
TL;DR: Skin sodium content is found to be closely linked to left ventricular mass in patients with CKD, unaffected by BP and total body overhydration, and interventions that reduce skin sodium content might improve cardiovascular outcomes in these patients.
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SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial.
Marina V. Karg,Agnes Bosch,Dennis Kannenkeril,Kristina Striepe,Christian Ott,M. P. Schneider,F. Boemke-Zelch,Peter Linz,Armin M. Nagel,Jens Titze,Michael Uder,Roland E. Schmieder +11 more
TL;DR: SGLT-2 inhibition with dapagliflozin resulted in a significant decrease in tissue sodium content of the skin after 6 weeks, which point to a decrease of total sodium content in patients with type 2 diabetes prone to cardiovascular complications, that might be mitigated by SGLT -2 inhibition.
Journal ArticleDOI
Spooky sodium balance
Jens Titze,Jens Titze,Anke Dahlmann,Kathrin Lerchl,Christoph W. Kopp,Natalia Rakova,Natalia Rakova,Agnes Schröder,Friedrich C. Luft,Friedrich C. Luft +9 more
TL;DR: TBNa was not dependent on sodium intake but instead exhibited far longer infradian rhythms independent of extracellular water, body weight, or blood pressure, which could be relevant to therapeutic strategies for hypertension and target-organ damage.
Journal ArticleDOI
The Pathophysiological Role of Interstitial Sodium in Heart Failure
Petra Nijst,Frederik H. Verbrugge,Lars Grieten,Matthias Dupont,Paul Steels,W.H. Wilson Tang,Wilfried Mullens +6 more
TL;DR: A better appreciation of this new Na(+) "compartment" might improve current management of HF and several therapies have been proven to stabilize interstitial GAG networks.
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