Journal ArticleDOI
90 years of monoamine oxidase: some progress and some confusion.
TLDR
This account concentrates key advances that explain why the monoamine oxidases remain of pharmacological and biochemical interest and on some areas of continuing uncertainty.Abstract:
It would not be practical to attempt to deal with all the advances that have informed our understanding of the behavior and functions of this enzyme over the past 90 years. This account concentrates key advances that explain why the monoamine oxidases remain of pharmacological and biochemical interest and on some areas of continuing uncertainty. Some issues that remain to be understood or are in need of further clarification are highlighted.read more
Citations
More filters
Journal ArticleDOI
Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications
Yu Chong,Qiang Liu,Cuicui Ge +2 more
TL;DR: This review systematically illustrates the classification of oxidase-mimicking nanozymes in terms of the acting group of representative substrates and discusses their possible catalytic mechanisms.
Brain monoamine oxidase A inhibition in cigarette smokers
N Orad,G Ene-Jackwang +1 more
TL;DR: The results show that tobacco smoke exposure is associated with marked reduction in brainMAOA, and this reduction is about half of that produced by a brief treatment with tranylcypromine, which suggests that MAO A inhibition needs to be considered as a potential contributing variable in the high rate of smoking in depression and in the development of more effective strategies for smoking cessation.
Journal ArticleDOI
Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease.
Liqian Gao,Liqian Gao,Wei Wang,Wei Wang,Xuan Wang,Fen Yang,Xie Liuxing,Jun Shen,Margaret A. Brimble,Qicai Xiao,Qicai Xiao,Shao Q. Yao +11 more
TL;DR: This review comprehensively summarize the design and working mechanisms of fluorescent probes along with their applications in the detection of various PD biomarkers and provides perspectives on how these limitations can be overcome to develop better fluorescent probes suitable for application in clinical trials in the future.
Journal ArticleDOI
Inhibitors of MAO-B and COMT: their effects on brain dopamine levels and uses in Parkinson's disease.
TL;DR: The scientific background to the localization and function of the enzymes, the physiological changes resulting from their inhibition, and the basic and clinical pharmacology of the various inhibitors and their role in treatment of Parkinson’s disease are described.
Journal ArticleDOI
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors
TL;DR: This work focused its attention on the researches performed in the last five years, involving chalcones or compounds that can be correlated to them, and classified the chalCones into different groups depending on their structural characteristics or common molecular properties.
References
More filters
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
From inflammation to sickness and depression: when the immune system subjugates the brain
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
Journal ArticleDOI
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
TL;DR: It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.
Journal ArticleDOI
Role of oxygen radicals in DNA damage and cancer incidence
TL;DR: The epidemiological trials together with in vitro experiments suggest that the optimal approach is to reduce endogenous and exogenous sources of oxidative stress, rather than increase intake of anti-oxidants.
Journal ArticleDOI
Some observations upon a new inhibitor of monoamine oxidase in brain tissue.
TL;DR: The hypothesis that in the enzyme prepared, the MAO is a binary system of enzymes each of which has a detectably different sensitivity to this particular inhibitor, is put forward and evidence after dialysis supports this hypothesis.
Related Papers (5)
The therapeutic potential of monoamine oxidase inhibitors.
Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness.
Moussa B.H. Youdim,Y S Bakhle +1 more