A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects
Nora Lang,Maria J. N. Pereira,Maria J. N. Pereira,Yuhan Lee,Ingeborg Friehs,Nikolay V. Vasilyev,Eric N. Feins,Klemens Ablasser,Eoin D. O'Cearbhaill,Chenjie Xu,Assunta Fabozzo,Robert F. Padera,Steve Wasserman,Franz Freudenthal,Lino Ferreira,Robert Langer,Jeffrey M. Karp,Pedro J. del Nido +17 more
TLDR
The engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood is described.Abstract:
Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well within wet and highly dynamic environments within the body. This is especially relevant to minimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis.read more
Citations
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Journal ArticleDOI
Tough adhesives for diverse wet surfaces
Jianyu Li,Jianyu Li,Jianyu Li,Adam D. Celiz,Adam D. Celiz,Jiawei Yang,Quansan Yang,Quansan Yang,Isaac Wamala,William Whyte,William Whyte,William Whyte,Bo Ri Seo,Bo Ri Seo,Nikolay V. Vasilyev,Joost J. Vlassak,Zhigang Suo,David J. Mooney,David J. Mooney +18 more
TL;DR: A bioinspired design for adhesives consisting of an adhesive surface with a flexible matrix to develop an adhesive that has the right level of stick but moves with the surrounding tissues, which is effective in the presence of blood and thus might work during wound repair.
PatentDOI
Dry double-sided material for adhesion of wet tissues and devices
Xuanhe Zhao,Hyunwoo Yuk +1 more
TL;DR: A new strong, biocompatible and biodegradable double-sided tape can adhere to wet tissues and devices through a mechanism involving rapid water removal from the surface, swift hydrogen and electrostatic interactions, and covalent bonding.
Journal ArticleDOI
Light in diagnosis, therapy and surgery.
TL;DR: The fundamentals of light–matter interactions are revisited, the applications of light in imaging, diagnosis, therapy and surgery are described, their clinical use is overviewed, and the promise of emerging light-based technologies are discussed.
Journal ArticleDOI
Hydrogel Adhesion: A Supramolecular Synergy of Chemistry, Topology, and Mechanics
Journal ArticleDOI
A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Yi Hong,Zhou Feifei,Hua Yujie,Xianzhu Zhang,Chengyao Ni,Dihao Pan,Zhang Yiqing,Deming Jiang,Long Yang,Qiuning Lin,Yiwei Zou,Dongsheng Yu,David E. Arnot,Xiaohui Zou,Linyong Zhu,Shufang Zhang,Hongwei Ouyang +16 more
TL;DR: A photo-reactive adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute is designed, which appears to offer significant clinical advantage as a traumatic wound sealant.
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A biodegradable and biocompatible gecko-inspired tissue adhesive
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