Journal ArticleDOI
Molecular Genetics of Attention-Deficit/Hyperactivity Disorder
Stephen V. Faraone,Roy H. Perlis,Alysa E. Doyle,Jordan W. Smoller,Jennifer J. Goralnick,Meredith A. Holmgren,Pamela Sklar +6 more
TLDR
Family, twin, and adoption studies provide compelling evidence that genes play a strong role in mediating susceptibility to ADHD, and seven genes for which the same variant has been studied in three or more case-control or family-based studies show statistically significant evidence of association with ADHD.About:
This article is published in Biological Psychiatry.The article was published on 2005-06-01. It has received 2087 citations till now. The article focuses on the topics: Twin study & Attention deficit hyperactivity disorder.read more
Citations
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Journal ArticleDOI
Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review.
TL;DR: Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD, and moderate effect sizes and lack of universality of EF deficits among individuals with ADHD suggest that EF weaknesses are neither necessary nor sufficient to cause all cases of ADHD.
Journal ArticleDOI
The role of the posterior cingulate cortex in cognition and disease.
Robert Leech,David J. Sharp +1 more
TL;DR: A novel model of the posterior cingulate cortex's function is synthesized into a model that influences attentional focus by 'tuning' whole-brain metastability and so adjusts how stable brain network activity is over time, and is tested within the framework of complex dynamic systems theory.
Journal ArticleDOI
Practice Parameter for the Assessment and Treatment of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
Steven R. Pliszka,William Bernet,Oscar G. Bukstein,Heather J. Walter,Valerie Arnold,Joseph H. Beitchman,R. Scott Benson,Allan K. Chrisman,John D. Hamilton,Helene Keable,Joan Kinlan,Jon McClellan,David Rue,Ulrich Schoettle,Saundra Stock,Kristin Kroeger Ptakowski,Jennifer Medicus,Larry Greenhill,Timothy E. Wilens,Thomas J. Spencer,Joe Biederman,Mina K. Dulcan,Lily Hechtman,Caryn L. Carlson,William E. Pelham,James M. Swanson,Russell A. Barkley,Joan P. Gerring,Guy Palmes,Cynthia W. Santos,Catherine Jaselskis +30 more
TL;DR: This practice parameter describes the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) based on the current scientific evidence and clinical consensus of experts in the field.
Journal ArticleDOI
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Ditte Demontis,Ditte Demontis,Raymond K. Walters,Raymond K. Walters,Joanna Martin,Joanna Martin,Joanna Martin,Manuel Mattheisen,Thomas Damm Als,Thomas Damm Als,Esben Agerbo,Esben Agerbo,Gisli Baldursson,Rich Belliveau,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Claire Churchhouse,Ashley Dumont,Nicholas Eriksson,Michael J. Gandal,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Katrina L. Grasby,Jakob Grove,Olafur O Gudmundsson,Olafur O Gudmundsson,Christine Søholm Hansen,Christine Søholm Hansen,Christine Søholm Hansen,Mads E. Hauberg,Mads E. Hauberg,Mads V. Hollegaard,Mads V. Hollegaard,Daniel P. Howrigan,Daniel P. Howrigan,Hailiang Huang,Hailiang Huang,Julian Maller,Alicia R. Martin,Alicia R. Martin,Nicholas G. Martin,Jennifer L. Moran,Jonatan Pallesen,Jonatan Pallesen,Duncan S. Palmer,Duncan S. Palmer,Carsten Bøcker Pedersen,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Marianne Giørtz Pedersen,Timothy Poterba,Timothy Poterba,Jesper Buchhave Poulsen,Jesper Buchhave Poulsen,Stephan Ripke,Stephan Ripke,Stephan Ripke,Elise B. Robinson,F. Kyle Satterstrom,F. Kyle Satterstrom,Hreinn Stefansson,Christine Stevens,Patrick Turley,Patrick Turley,G. Bragi Walters,G. Bragi Walters,Hyejung Won,Hyejung Won,Margaret J. Wright,Ole A. Andreassen,Philip Asherson,Christie L. Burton,Dorret I. Boomsma,Bru Cormand,Søren Dalsgaard,Barbara Franke,Joel Gelernter,Joel Gelernter,Daniel H. Geschwind,Daniel H. Geschwind,Hakon Hakonarson,Jan Haavik,Jan Haavik,Henry R. Kranzler,Henry R. Kranzler,Jonna Kuntsi,Kate Langley,Klaus-Peter Lesch,Klaus-Peter Lesch,Klaus-Peter Lesch,Christel M. Middeldorp,Christel M. Middeldorp,Andreas Reif,Luis Augusto Rohde,Panos Roussos,Russell Schachar,Pamela Sklar,Edmund J.S. Sonuga-Barke,Patrick F. Sullivan,Patrick F. Sullivan,Anita Thapar,Joyce Y. Tung,Irwin D. Waldman,Sarah E. Medland,Kari Stefansson,Kari Stefansson,Merete Nordentoft,Merete Nordentoft,David M. Hougaard,David M. Hougaard,Thomas Werge,Thomas Werge,Thomas Werge,Ole Mors,Ole Mors,Preben Bo Mortensen,Mark J. Daly,Stephen V. Faraone,Anders D. Børglum,Anders D. Børglum,Benjamin M. Neale,Benjamin M. Neale +126 more
TL;DR: A genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls identifies variants surpassing genome- wide significance in 12 independent loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.
Journal ArticleDOI
SeminarAttention-deficit hyperactivity disorder
TL;DR: Converging evidence from animal and human studies implicates the dysregulation of frontal-subcortical-cerebellar catecholaminergic circuits in the pathophysiology of ADHD, and molecular imaging studies suggest that abnormalities of the dopamine transporter lead to impaired neurotransmission.
References
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Eric S. Lander,Leonid Kruglyak +1 more
TL;DR: Specific standards designed to maintain rigor while also promoting communication are proposed for the interpretation of linkage results in genetic studies under way for many complex traits.
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The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication.
Ronald C. Kessler,Lenard A. Adler,Russell A. Barkley,Joseph Biederman,C. Keith Conners,M.P.H. Olga Demler,Stephen V. Faraone,Laurence L. Greenhill,Mary J. Howes,Kristina Secnik,Thomas J. Spencer,T. Bedirhan Üstün,Ellen E. Walters,Alan M. Zaslavsky +13 more
TL;DR: Efforts are needed to increase the detection and treatment of adult ADHD and research is needed to determine whether effective treatment would reduce the onset, persistence, and severity of disorders that co-occur with adult ADHD.
Journal ArticleDOI
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
TL;DR: In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission.