A Consensus on the Diagnosis and Treatment of Acromegaly Complications
Shlomo Melmed,Felipe F. Casanueva,Anne Klibanski,Marcello D. Bronstein,Philippe Chanson,Philippe Chanson,Steven W. J. Lamberts,Christian J. Strasburger,John A.H. Wass,Andrea Giustina +9 more
TLDR
In March 2011, the Acromegaly Consensus Group met to revise and update the guidelines on the diagnosis and treatment of acromEGaly complications and the need for a new disease staging model was considered, and design of such a tool was proposed.Abstract:
In March 2011, the Acromegaly Consensus Group met to revise and update the guidelines on the diagnosis and treatment of acromegaly complications. The meeting was sponsored by the Pituitary Society and the European Neuroendocrinology Association and included experts skilled in the management of acromegaly. Complications considered included cardiovascular, endocrine and metabolic, sleep apnea, bone diseases, and mortality. Outcomes in selected, related clinical conditions were also considered, and included pregnancy, familial acromegaly and invasive macroadenomas. The need for a new disease staging model was considered, and design of such a tool was proposed.read more
Citations
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Journal ArticleDOI
Acromegaly: An Endocrine Society Clinical Practice Guideline
Laurence Katznelson,Edward R. Laws,Shlomo Melmed,Mark E. Molitch,Mohammad Hassan Murad,Andrea L. Utz,John A.H. Wass +6 more
TL;DR: This evidence-based guideline addresses important clinical issues regarding the evaluation and management of acromegaly, including the appropriate biochemical assessment, a therapeutic algorithm, including use of medical monotherapy or combination therapy, and management during pregnancy.
Journal ArticleDOI
Expert consensus document: A consensus on the medical treatment of acromegaly
Andrea Giustina,Philippe Chanson,David L. Kleinberg,Marcello D. Bronstein,David R. Clemmons,Anne Klibanski,Aart Jan van der Lely,Christian J. Strasburger,Steven W. J. Lamberts,Ken K. Y. Ho,Felipe F. Casanueva,Shlomo Melmed +11 more
TL;DR: This document represents the conclusions of the workshop consensus and considered treatment goals covering biochemical, clinical and tumour volume outcomes, and the place in guidelines of somatostatin receptor ligands, growth hormone receptor antagonists and dopamine agonists.
Journal ArticleDOI
Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update.
TL;DR: Incidence of mortality, its correlation with GH, and IGF-I levels and the shift in the main cause of mortality in patients with acromegaly are addressed and the effects of different acromEGaly treatment options on these complications are detailed.
Journal ArticleDOI
A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update.
Andrea Giustina,Ariel L. Barkan,Albert Beckers,Nienke R. Biermasz,Beverly M. K. Biller,Cesar Luiz Boguszewski,Marek Bolanowski,Vivien Bonert,Marcello D. Bronstein,Felipe F. Casanueva,David R. Clemmons,Annamaria Colao,Diego Ferone,Maria Fleseriu,Stefano Frara,Mônica R. Gadelha,Ezio Ghigo,Mark Gurnell,Anthony P. Heaney,Ken K. Y. Ho,Adriana G. Ioachimescu,Laurence Katznelson,Fahrettin Kelestimur,John J. Kopchick,Michal Krsek,Steven W. J. Lamberts,Marco Losa,Anton Luger,Pietro Maffei,Mónica Marazuela,Gherardo Mazziotti,Moisés Mercado,Pietro Mortini,Sebastian J C M M Neggers,Alberto M. Pereira,Stephan Petersenn,Manel Puig-Domingo,Roberto Salvatori,Ilan Shimon,Christian J. Strasburger,Stylianos Tsagarakis,A. J. van der Lely,John A.H. Wass,Maria Chiara Zatelli,Shlomo Melmed +44 more
TL;DR: Evidence-based approach consensus recommendations address important clinical issues regarding multidisciplinary management of acromegaly-related cardiovascular, endocrine, metabolic, and oncologic comorbidities, sleep apnea, and bone and joint disorders and their sequelae, as well as their effects on quality of life and mortality.
Journal ArticleDOI
Acromegaly at diagnosis in 3173 patients from the Liège Acromegaly Survey (LAS) Database
Patrick Petrossians,Adrian Daly,Emil Natchev,Luigi Maione,Karin Blijdorp,M Sahnoun-Fathallah,Renata S. Auriemma,Alpha Mamadou Diallo,Anna-Lena Hulting,Diego Ferone,Vaclav Hana,Silvia Filipponi,Caroline Sievers,Claudia Nogueira,Carmen Fajardo-Montañana,Davide Carvalho,Günter K. Stalla,Marie Lise Jaffrain-Rea,Brigitte Delemer,Annamaria Colao,Thierry Brue,Sebastian J C M M Neggers,Sabina Zacharieva,Philippe Chanson,Albert Beckers +24 more
TL;DR: This study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromEGaly at diagnosis.
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