A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence.
Zhou Shen,Gang Wang,Yiling Yang,Jiale Shi,Liurong Fang,Fang Li,Shaobo Xiao,Zhen F. Fu,Zhen F. Fu,Guiqing Peng +9 more
TLDR
It is demonstrated that alphacoronavirus nsp1 is an essential virulence determinant, providing a potential paradigm for the development of a new attenuated vaccine based on modified nSp1.About:
This article is published in Journal of Biological Chemistry.The article was published on 2019-09-13 and is currently open access. It has received 52 citations till now. The article focuses on the topics: Coronavirus & Alphacoronavirus.read more
Citations
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A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses.
TL;DR: Current understanding of the induction of a proinflammatory cytokine storm by other highly pathogenic human coronaviruses, their adaptation to humans and their usurpation of the cell death programmes are summarized.
Journal ArticleDOI
Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0).
TL;DR: An operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital.
Journal ArticleDOI
Structure of nonstructural protein 1 from SARS-CoV-2.
TL;DR: A comparison of the authors' structure with the SARS-CoV-1 nsp1 structure reveals how mutations alter the conformation of flexible loops, inducing the formation of novel secondary structural elements and new surface features.
Journal ArticleDOI
Structural characterization of Nonstructural protein 1 from SARS-CoV-2.
TL;DR: The crystal structure of the globular domain of SARS-CoV-2 Nsp1 is reported, encompassing residues 13 to 127, at a resolution of 1.65 Å, and reveals how variations in amino acid sequence manifest as distinct structural features.
Journal ArticleDOI
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression.
Keisuke Nakagawa,Shinji Makino +1 more
TL;DR: A review of gene expression suppression functions of nonstructural protein 1 (nsp1) of SARS-CoV nsp1 is presented in this paper, with a primary focus on SARS CoV Nsp1.
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