A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
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Journal ArticleDOI
Neurocognitive explanations of the antisocial personality disorders
Tames Blair,Uta Frith +1 more
TL;DR: This paper aims to provide an understanding of the antisocial personality disorders (APDs) that is informed by developmental cognitive neuroscience and concludes that the development of the APDs is associated with an impairment in emotional processing and that this impairment may be due to dysfunction within a circuit which involves the amygdala.
Journal ArticleDOI
Neural networks related to dysfunctional face processing in autism spectrum disorder
Thomas Nickl-Jockschat,Claudia Rottschy,Johanna Thommes,Frank Schneider,Angela R. Laird,Peter T. Fox,Simon B. Eickhoff +6 more
TL;DR: A functionally and structurally disturbed network of occipital regions related primarily to face processing, which interact with inferior frontal as well as limbic regions and may be the core of aberrant face processing and reduced interest in faces in ASD is suggested.
Journal ArticleDOI
The role of the amygdala in face perception and evaluation
TL;DR: It is argued that faces automatically evoke responses not only in these regions but also in the amygdala, and one of the functions of the amygdala is to bias attention to atypical faces, which are associated with higher uncertainty.
Journal ArticleDOI
Fear conditioning and brain activity: a positron emission tomography study in humans.
TL;DR: Fear conditioning increased rCBF in the central gray of the midbrain; bilaterally in the hypothalamus, the thalamus, and the left striatum; and in the right and left anterior cingulate and right prefrontal cortices; and only neural activity in the left cerebellum solely reflected processes associated with true Pavlovian conditioning.
Book ChapterDOI
The cingulate cortex and limbic systems for action, emotion, and memory.
TL;DR: Damage to the anterior cingulate cortex can impair hippocampal episodic memory and retrieval, especially the spatial component, and these functions are related to the place of this proisocortical limbic region in brain connectivity.
References
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Statistical parametric maps in functional imaging: A general linear approach
Karl J. Friston,Andrew P. Holmes,Keith J. Worsley,J-B. Poline,Chris D. Frith,Richard S. J. Frackowiak +5 more
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The Expression of the Emotions in Man and Animals
TL;DR: The Expression of the Emotions in Man and Animals Introduction to the First Edition and Discussion Index, by Phillip Prodger and Paul Ekman.
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Spatial registration and normalization of images
Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
TL;DR: A general technique that facilitates nonlinear spatial (stereotactic) normalization and image realignment is presented that minimizes the sum of squares between two images following non linear spatial deformations and transformations of the voxel (intensity) values.
Journal ArticleDOI
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala.
Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.