A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
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Disgust in pre-clinical Huntington's disease: a longitudinal study.
TL;DR: Recognising facial expressions of disgust was significantly impaired on all three assessments in the HD+ group, while recognition of vocal emotions and the experience of emotions were largely unaffected, confirming that deficits in recognition of facial expression of disgust are an early correlate of carrying the gene for Huntington's disease.
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An fMRI study of facial emotion processing in children and adolescents with 22q11.2 deletion syndrome.
R Azuma,R Azuma,Quinton Deeley,Quinton Deeley,Linda E. Campbell,Eileen Daly,Vincent Giampietro,Michael Brammer,Kieran C. Murphy,Declan G. Murphy +9 more
TL;DR: Regions involved in face processing, including fusiform-extrastriate cortices, anterior cingulate gyri, and superomedial prefrontal cortices are activated by facial expressions of fearful, disgusted, and neutral expressions in children with 22q11DS but generally to a lesser degree than in controls.
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Regional brain atrophy in progressive supranuclear palsy and Lewy body disease.
TL;DR: Evidence is provided for selective regional atrophy that correlates with the underlying pathology of PSP and Lewy body disease and greater frontal lobe atrophy correlated with clinical dementia in PSP.
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Acute effects of heroin on negative emotional processing: relation of amygdala activity and stress-related responses.
André Schmidt,André Schmidt,Stefan Borgwardt,Hana Gerber,Gerhard A. Wiesbeck,Otto Schmid,Anita Riecher-Rössler,Renata Smieskova,Renata Smieskova,Undine E. Lang,Marc Walter +10 more
TL;DR: The results show a direct relation between the acute heroin effects on stress-related emotions, stress reactivity, and left amygdala response to negative facial expressions and provide new insights into the mechanisms underlying negative reinforcement in heroin addiction and the effects of regular heroin substitution.
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The role of the amygdala in signaling prospective outcome of choice.
Itamar Kahn,Itamar Kahn,Yehezkel Yeshurun,Pia Rotshtein,Itzhak Fried,Itzhak Fried,Dafna Ben-Bashat,Talma Hendler +7 more
TL;DR: A critical period, when choice has been made but outcome was still unknown, activated the amygdala preferentially following the choice that entailed risk of loss, and this response of the amygdala differentiated between subject's covert choice of either playing fair or foul.
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TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.