A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
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Individuals with Autism Spectrum Disorder Show Normal Responses to a Fear Potential Startle Paradigm
TL;DR: The results suggest that this aspect of amygdala function, namely fear conditioning and potentiation of the startle response, is intact in individuals with autism.
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Fixing the stimulus-as-fixed-effect fallacy in task fMRI
TL;DR: A Bayesian mixed model (the random stimulus model; RSM) is developed that can be used to improve parameter estimates, properly control false positive rates, and test novel research hypotheses about stimulus-level variability in human brain responses.
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The neuroscience of social interaction : decoding, imitating, and influencing the actions of others
Chris D. Frith,Daniel M. Wolpert +1 more
TL;DR: This book presents the unifying computational framework for motor control and social interaction, a rapprochement between developmental psychology and cognitive neuroscience and the study of social interactions.
Journal ArticleDOI
Differences in startle reactivity during the perception of angry and fearful faces.
TL;DR: The results of two experiments indicated that viewing anger was associated with a significantly heightened startle response (p < .05) relative to viewing fear, happy, and neutral, which suggests that while anger and fear faces convey messages of "threat", their priming effect on startle circuitry differs.
Journal ArticleDOI
Boys do it the right way: sex-dependent amygdala lateralization during face processing in adolescents.
Sophia Schneider,Jan Peters,Uli Bromberg,Stefanie Brassen,Mareike M. Menz,Stephan F. Miedl,Eva Loth,Tobias Banaschewski,Alexis Barbot,Gareth J. Barker,Patricia J. Conrod,Jeffrey W. Dalley,Herta Flor,Jürgen Gallinat,Hugh Garavan,Andreas Heinz,Bernd Itterman,Catherine Mallik,Karl Mann,Eric Artiges,Tomáš Paus,Tomáš Paus,Tomáš Paus,Jean-Baptiste Poline,Marcella Rietschel,Laurence J. Reed,Michael N. Smolka,Rainer Spanagel,Claudia Speiser,Andreas Ströhle,Maren Struve,Gunter Schumann,Christian Büchel +32 more
TL;DR: The results indicate that adolescents display a sex-dependent lateralization of amygdala activation that is also present in basic processes of emotional perception, which suggests aSex-dependent development of human emotion processing and may further implicate possible etiological pathways for mental disorders most frequent in adolescent males.
References
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Journal ArticleDOI
Statistical parametric maps in functional imaging: A general linear approach
Karl J. Friston,Andrew P. Holmes,Keith J. Worsley,J-B. Poline,Chris D. Frith,Richard S. J. Frackowiak +5 more
TL;DR: In this paper, the authors present a general approach that accommodates most forms of experimental layout and ensuing analysis (designed experiments with fixed effects for factors, covariates and interaction of factors).
Book
The Expression of the Emotions in Man and Animals
TL;DR: The Expression of the Emotions in Man and Animals Introduction to the First Edition and Discussion Index, by Phillip Prodger and Paul Ekman.
Journal ArticleDOI
Spatial registration and normalization of images
Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
TL;DR: A general technique that facilitates nonlinear spatial (stereotactic) normalization and image realignment is presented that minimizes the sum of squares between two images following non linear spatial deformations and transformations of the voxel (intensity) values.
Journal ArticleDOI
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala.
Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.