A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
More filters
Journal ArticleDOI
Amygdala responsiveness to emotional words is modulated by subclinical anxiety and depression.
Inga Laeger,Christian Dobel,Udo Dannlowski,Udo Dannlowski,Harald Kugel,Dominik Grotegerd,Johanna Kissler,Katharina Keuper,Annuschka Eden,Pienie Zwitserlood,Peter Zwanzger +10 more
TL;DR: Results suggest a modulation of negative-word processing by subclinical depression and anxiety, as well as possible prefrontal compensatory processes during unintentional emotion regulation in subjects with higher trait anxiety.
Journal ArticleDOI
Emotion and cortical-subcortical function: conceptual developments
TL;DR: A conceptual analysis indicates that there is considerable confusion as to what experimental work to this time indicates about the role of cortical and subcortical structures in the expression of emotions, and attempts to clarify what can and cannot be justified as established concerning the workings of the brain and emotions.
Journal ArticleDOI
Age-related differences in brain activity underlying identification of emotional expressions in faces
TL;DR: The results support previous research demonstrating age differences in brain activity during emotional processing, and suggest possible age-related differences in cognitive strategy during identification of happy faces, despite no effect of age on this ability.
Journal ArticleDOI
Distinct contributions of the amygdala and hippocampus to fear expression
TL;DR: Data show that the hippocampus and amygdala contribute independently to the overall expression of defensive responses, and both operated groups showed shorter food‐retrieval latencies and exhibited fewer defensive and more approach behaviors when exposed to the fear‐provoking stimuli.
Journal ArticleDOI
Faces and eyes in human lateral prefrontal cortex.
Annie W. Chan,Paul E. Downing +1 more
TL;DR: In this paper, the authors examined a region at the junction of the right inferior frontal sulcus and the precentral sulcus (right inferior frontal junction or rIFJ) that responds more to faces than to several other object categories.
References
More filters
Journal ArticleDOI
Statistical parametric maps in functional imaging: A general linear approach
Karl J. Friston,Andrew P. Holmes,Keith J. Worsley,J-B. Poline,Chris D. Frith,Richard S. J. Frackowiak +5 more
TL;DR: In this paper, the authors present a general approach that accommodates most forms of experimental layout and ensuing analysis (designed experiments with fixed effects for factors, covariates and interaction of factors).
Book
The Expression of the Emotions in Man and Animals
TL;DR: The Expression of the Emotions in Man and Animals Introduction to the First Edition and Discussion Index, by Phillip Prodger and Paul Ekman.
Journal ArticleDOI
Spatial registration and normalization of images
Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
TL;DR: A general technique that facilitates nonlinear spatial (stereotactic) normalization and image realignment is presented that minimizes the sum of squares between two images following non linear spatial deformations and transformations of the voxel (intensity) values.
Journal ArticleDOI
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala.
Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.