A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
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The amygdala of patients with Parkinson’s disease is silent in response to fearful facial expressions
TL;DR: Somatosensory recruitment may overcome the mild cognitive emotional deficits that are present in patients with PD owing to a dysfunction of the amygdala, and Corticostriatal connections may be variably affected by a lack of dopamine or by pathological changes in the amygdala.
Journal ArticleDOI
Cortical correlates of face and scene inversion: a comparison.
Russell A. Epstein,J. Stephen Higgins,Whitney E. Parker,Geoffrey K. Aguirre,Samantha Cooperman +4 more
TL;DR: These results demonstrate that both face and scene inversion cause a shift from specialized processing streams towards generic object-processing mechanisms; however, this shift only leads to a reliable behavioral penalty in the case of face inversion.
Journal ArticleDOI
Resting State Functional Connectivity in Mild Traumatic Brain Injury at the Acute Stage: Independent Component and Seed-Based Analyses
Armin Iraji,Randall R. Benson,Robert D. Welch,Brian J. O'Neil,John L. Woodard,Syed Imran Ayaz,Andrew Kulek,Valerie Mika,P. Medado,Hamid Soltanian-Zadeh,Tianming Liu,E. Mark Haacke,Zhifeng Kou +12 more
TL;DR: Resting-state functional connectivity of the DMN could serve as a potential biomarker for improved detection of mTBI in the acute setting and alterations of multiple brain networks at the resting state are demonstrated.
Journal ArticleDOI
Major depression is associated with impaired processing of emotion in music as well as in facial and vocal stimuli.
C. Naranjo,Charles Kornreich,Salvatore Campanella,Xavier Noël,Yun-Marie Vandriette,B. Gillain,X. De Longueville,Benjamin Delatte,Paul Verbanck,Eric Constant +9 more
TL;DR: Major depression is associated with a general negative bias in the processing of emotional stimuli, and emotional processing impairment in depression is not confined to interpersonal stimuli, being also present in the ability to feel music accurately.
Book ChapterDOI
Investigating audiovisual integration of emotional signals in the human brain.
TL;DR: This chapter reviews behavioural, neuroanatomical, electrophysiological and neuroimaging studies pertaining to audiovisual integration of emotional communicative signals and argues that these approaches provide complementing information as they assess different aspects of multisensory Integration of emotional information.
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Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
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Journal ArticleDOI
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Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.