A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
More filters
Journal ArticleDOI
Analysis of functional brain connections for positive-negative emotions using phase locking value.
TL;DR: Results show notable hemispheric lateralization as phase synchronization values between channels are significant and high in right hemisphere for all emotions and left frontal electrodes are also found to have control over emotion in terms of functional connectivity.
Journal ArticleDOI
The psychobiology of obsessive-compulsive disorder: how important is the role of disgust?
TL;DR: Findings on disgust and its mediating CSTC circuits may generate useful hypotheses for OCD research, as psychobiologic models of panic disorder and posttraumatic stress disorder have been strengthened by the inclusion of preclinical work on amygdala-mediated fear conditioning.
Journal ArticleDOI
Fear and anxiety: a simultaneous concept analysis.
Esther Jean Bay,Donna L. Algase +1 more
TL;DR: Fear and anxiety are distinct diagnoses guided by separate brain mechanisms and the author offers a process model for further critique by peers and clinical populations.
Journal ArticleDOI
Event-related potentials of attentional bias toward faces in the dot-probe task: A systematic review.
Robert D. Torrence,Lucy J. Troup +1 more
TL;DR: This review systematically searched for articles that used the dot-probe task with facial expressions and measured neural correlates with ERP and found that some of the inconsistencies might be the cause of methodological differences.
Journal ArticleDOI
Neurophysiological correlates of habituation during exposure in spider phobia.
Dick J. Veltman,Wim E. Tuinebreijer,Daniël Winkelman,Adriaan A. Lammertsma,Menno P. Witter,Raymond J. Dolan,Paul M. G. Emmelkamp +6 more
TL;DR: It is concluded that prolonged exposure to phobic stimuli is associated with a significant decrease in bilateral anterior MTL regional cerebral blood flow, which implicates this region in phobic fear.
References
More filters
Journal ArticleDOI
Statistical parametric maps in functional imaging: A general linear approach
Karl J. Friston,Andrew P. Holmes,Keith J. Worsley,J-B. Poline,Chris D. Frith,Richard S. J. Frackowiak +5 more
TL;DR: In this paper, the authors present a general approach that accommodates most forms of experimental layout and ensuing analysis (designed experiments with fixed effects for factors, covariates and interaction of factors).
Book
The Expression of the Emotions in Man and Animals
TL;DR: The Expression of the Emotions in Man and Animals Introduction to the First Edition and Discussion Index, by Phillip Prodger and Paul Ekman.
Journal ArticleDOI
Spatial registration and normalization of images
Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
TL;DR: A general technique that facilitates nonlinear spatial (stereotactic) normalization and image realignment is presented that minimizes the sum of squares between two images following non linear spatial deformations and transformations of the voxel (intensity) values.
Journal ArticleDOI
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala.
Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.