A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
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What does the amygdala contribute to social cognition
TL;DR: The amygdala processes a psychological stimulus dimension related to saliency or relevance; mechanisms have been identified to link it to processing unpredictability; and insights from reward learning have situated it within a network of structures that include the prefrontal cortex and the ventral striatum in processing the current value of stimuli.
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Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans.
Hugo D. Critchley,Douglas R. Corfield,M. P. Chandler,Christopher J. Mathias,Christopher J. Mathias,Raymond J. Dolan +5 more
TL;DR: Evidence is provided for the involvement of areas previously implicated in cognitive and emotional behaviours in the representation of peripheral autonomic states, consistent with a functional organization that produces integrated cardiovascular response patterns in the service of volitional andotional behaviours.
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The Link between Social Cognition and Self-referential Thought in the Medial Prefrontal Cortex
TL;DR: Results suggest that self-reflection may be used to infer the mental states of others when they are sufficiently similar to self, a test of simulation theory's prediction that inferences based on self- Reflection should only be made for similar others.
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The structural and functional connectivity of the amygdala: From normal emotion to pathological anxiety
M. Justin Kim,Rebecca A. Loucks,Amy L. Palmer,Annemarie C. Brown,Kimberly M. Solomon,Ashley N. Marchante,Paul J. Whalen +6 more
TL;DR: The capacity for efficient crosstalk between the amygdala and the mPFC, which is represented as the strength of the amygdala-mPFC circuitry, is crucial to beneficial outcomes in terms of reported anxiety.
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Emotion, olfaction, and the human amygdala: Amygdala activation during aversive olfactory stimulation
David H. Zald,José V. Pardo +1 more
TL;DR: Evidence is provided that the human amygdala participates in the hedonic or emotional processing of olfactory stimuli and the activity within the left amygdala was associated significantly with subjective ratings of perceived aversiveness.
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Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
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Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.