A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
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A Role for the Human Amygdala in Recognizing Emotional Arousal From Unpleasant Stimuli
TL;DR: The findings suggest that the amygdala plays a critical role in knowledge concerning the arousal of negative emotions, a function that may explain the impaired recognition of fear and anger in patients with bilateral amygdala damage, and one that is consistent with the amygdala's role in processing stimuli related to threat and danger.
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Activation of anterior paralimbic structures during guilt-related script-driven imagery
Lisa M. Shin,Lisa M. Shin,Darin D. Dougherty,Scott P. Orr,Roger K. Pitman,Mark Lasko,Michael L. Macklin,Nathaniel M. Alpert,Alan J. Fischman,Scott L. Rauch +9 more
TL;DR: These results, along with those of previous studies, are consistent with the notion that anterior paralimbic regions of the brain mediate negative emotional states in healthy individuals.
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Effect of a single dose of citalopram on amygdala response to emotional faces
TL;DR: Such an immediate effect of an SSRI on amygdala responses to threat supports the idea that antidepressants have an earlier onset of therapeutically relevant effects than conventionally thought.
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Impaired recognition of disgust in Huntington's disease gene carriers.
TL;DR: People who were free from clinical symptoms and did not perform significantly more poorly than non-carriers on any of the background tests, on any other face processing tasks, and even for recognition of any other basic emotion points strongly to the importance of the basal ganglia in the emotion of disgust.
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Specific brain processing of facial expressions in people with alexithymia: an H215O‐PET study
Michiko Kano,Shin Fukudo,Jiro Gyoba,Miyuki Kamachi,Masaaki Tagawa,Hideki Mochizuki,Masatoshi Itoh,Michio Hongo,Kazuhiko Yanai +8 more
TL;DR: It is suggested that people with alexithymia process facial expressions differently from people without alexITHymia, and that this difference may account for the disorder of affect regulation and consequent peculiar behaviour in people with the disease.
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Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
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Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.