A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
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Fear Recognition Ability Predicts Differences in Social Cognitive and Neural Functioning in Men
TL;DR: It is suggested that important individual differences in social cognitive skills are expressed within the healthy male population, which appear to have a basis in a compromised neural system that underpins social information processing.
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Neural activation in the “reward circuit” shows a nonlinear response to facial attractiveness
TL;DR: This study is the first to demonstrate heightened responses to both rewarding and aversive faces in numerous areas of this putative reward circuit, and discovery of nonlinear responses to attractiveness throughout the reward circuit echoes the history of amygdala research.
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THE HUMAN AMYGDALA IS INVOLVED IN GENERAL BEHAVIORAL RELEVANCE DETECTION: EVIDENCE FROM AN EVENT-RELATED FUNCTIONAL MAGNETIC RESONANCE IMAGING Go-NoGo TASK
Olga Therese Ousdal,Jimmy Jensen,Andres Server,Ahmad R. Hariri,Per H. Nakstad,Ole A. Andreassen +5 more
TL;DR: A role for the human amygdala in general detection of behaviorally relevant stimuli is supported in event related functional magnetic resonance imaging (fMRI) and a modified Go-NoGo task.
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Amygdala volume correlates positively with fearfulness in normal healthy girls
TL;DR: A positive correlation between right amygdala volume in girls and normal fearfulness and amygdala morphology is found and may indicate that variation in amygdala morphology marks susceptibility to internalizing disorders.
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Anatomical MRI findings in mood and anxiety disorders.
TL;DR: In vivo structural magnetic resonance imaging (MRI) studies have evaluated the brain anatomy of various psychiatric disorders, allowing the investigation of putative abnormal brain circuits possibly involved in the patophysiology of psychiatric disorders.
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Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
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Journal ArticleDOI
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala.
Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.