A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
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The dark side of emotion: the addiction perspective.
TL;DR: The thesis argued here is that the brain has specific neurochemical neurocircuitry coded by the hedonic extremes of pleasant and unpleasant emotions that have been identified through the study of opponent processes in the domain of addiction.
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An Investigation of the Structural, Connectional, and Functional Subspecialization in the Human Amygdala
TL;DR: In this article, the authors employed methods for large-scale data mining to perform a connectivity-derived parcellation of the human amygdala based on whole-brain coactivation patterns computed for each seed voxel.
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A functional anatomy of anticipatory anxiety.
Phyllis Chua,M. Krams,Ivan Toni,Richard E. Passingham,Richard E. Passingham,Raymond J. Dolan,Raymond J. Dolan +6 more
TL;DR: Findings support the role of paralimbic structures as neural substrates of anticipatory anxiety and the failure to demonstrate behavioral and neurophysiological changes with the distractor task may reflect the modest increases in anxiety with the shock, the relatively simple distractionor task, and small sample size.
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A developmental examination of amygdala response to facial expressions
Amanda E. Guyer,Christopher S. Monk,Erin B. McClure-Tone,Eric E. Nelson,Roxann Roberson-Nay,Abby D. Adler,Stephen J. Fromm,Ellen Leibenluft,Daniel S. Pine,Monique Ernst +9 more
TL;DR: There is a need for more work examining developmental changes in the amygdala's response to fearful faces and in amygdala functional connectivity during face processing, according to prior research on amygdala function and development.
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Activity in the human brain predicting differential heart rate responses to emotional facial expressions.
Hugo D. Critchley,Pia Rotshtein,Yoko Nagai,John P. O'Doherty,Christopher J. Mathias,Raymond J. Dolan +5 more
TL;DR: This work shows that orienting heart rate acceleration to emotional face stimuli was modulated as a function of the emotion depicted, and suggests that amygdala, insula, anterior cingulate, and brainstem represent an interface for selective generation of visceral reactions that contribute to the embodied component of emotional reaction.
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Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
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Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.