A differential neural response in the human amygdala to fearful and happy facial expressions
J. S. Morris,Chris D. Frith,David I. Perrett,Duncan Rowland,Andrew W. Young,Andrew J. Calder,Raymond J. Dolan +6 more
TLDR
Direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness is reported, providing direct evidence that the humangdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.Abstract:
The amygdala is thought to play a crucial role in emotional and social behaviour. Animal studies implicate the amygdala in both fear conditioning and face perception. In humans, lesions of the amygdala can lead to selective deficits in the recognition of fearful facial expressions and impaired fear conditioning, and direct electrical stimulation evokes fearful emotional responses. Here we report direct in vivo evidence of a differential neural response in the human amygdala to facial expressions of fear and happiness. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. The neuronal response in the left amygdala was significantly greater to fearful as opposed to happy expressions. Furthermore, this response showed a significant interaction with the intensity of emotion (increasing with increasing fearfulness, decreasing with increasing happiness). The findings provide direct evidence that the human amygdala is engaged in processing the emotional salience of faces, with a specificity of response to fearful facial expressions.read more
Citations
More filters
Journal ArticleDOI
Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers.
Daniela Eser,Gregor Leicht,Jürgen Lutz,Stephan Wenninger,Valerie Kirsch,Cornelius Schüle,Susanne Karch,Thomas C. Baghai,Oliver Pogarell,Christine Born,Rainer Rupprecht,Christoph Mulert +11 more
TL;DR: Overall brain activation patterns are not related to the subjective anxiety response to CCK‐4, but amygdala activation may be involved in the subjective perception of CCK•4‐induced fear.
Posted Content
The Human Face of Game Theory: Trust and Reciprocity in Sequential Games
TL;DR: In this paper, the authors examine the emotional cues registered by the face and investigate the meaning of those cues mean for signaling an actor's intentions in a two-branch sequential bargaining game.
Journal ArticleDOI
BDNF, relative preference, and reward circuitry responses to emotional communication
Gregory P. Gasic,Jordan W. Smoller,Roy H. Perlis,Mei Sun,Sang Lee,Byoung Woo Kim,Myung Joo Lee,Daphne J. Holt,Anne J. Blood,Nikos Makris,D.K. Kennedy,Richard D. Hoge,Richard D. Hoge,J. Calhoun,Maurizio Fava,James F. Gusella,Hans C. Breiter +16 more
TL;DR: It is shown that functional allelic variation in BDNF modulates human brain circuits processing reward/aversion information and relative preference transactions and that this variation affects human judgment and decision‐making regarding relative preference.
Journal ArticleDOI
Increased amygdala activation to emotional auditory stimuli in the blind.
TL;DR: In this article, the authors used functional magnetic resonance imaging in sighted and connatally blind volunteers to investigate amygdala involvement in auditory emotional processing, and found that the blind showed robust selective activation in the amygdala to fearful and angry compared to neutral voices but also showed stronger activation to those stimuli than sighted participants.
Journal ArticleDOI
Psychophysiological Assessment of Prejudice: Past Research, Current Status, and Future Directions
TL;DR: Several psychophysiological approaches have been found valuable for assessing the valence and intensity of emotional responses and the availability of these tools make prejudice research ready for a return to psychophysiology methodologies.
References
More filters
Journal ArticleDOI
Statistical parametric maps in functional imaging: A general linear approach
Karl J. Friston,Andrew P. Holmes,Keith J. Worsley,J-B. Poline,Chris D. Frith,Richard S. J. Frackowiak +5 more
TL;DR: In this paper, the authors present a general approach that accommodates most forms of experimental layout and ensuing analysis (designed experiments with fixed effects for factors, covariates and interaction of factors).
Book
The Expression of the Emotions in Man and Animals
TL;DR: The Expression of the Emotions in Man and Animals Introduction to the First Edition and Discussion Index, by Phillip Prodger and Paul Ekman.
Journal ArticleDOI
Spatial registration and normalization of images
Karl J. Friston,John Ashburner,Chris D. Frith,Jean-Baptiste Poline,Jon D. Heather,Richard S. J. Frackowiak +5 more
TL;DR: A general technique that facilitates nonlinear spatial (stereotactic) normalization and image realignment is presented that minimizes the sum of squares between two images following non linear spatial deformations and transformations of the voxel (intensity) values.
Journal ArticleDOI
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala.
Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.