A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis.
Ashley Busacker,John D. Newell,Thomas J. Keefe,Eric A. Hoffman,Janice Cook Granroth,Mario Castro,Sean B. Fain,Sally E. Wenzel +7 more
TLDR
Quantitative CT-determined air trapping in asthmatic subjects identifies a group of individuals at high risk for severe disease, including history of pneumonia, neutrophilic inflammation, and atopy.About:
This article is published in Chest.The article was published on 2009-01-01 and is currently open access. It has received 261 citations till now. The article focuses on the topics: Air trapping & Risk factor.read more
Citations
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Journal ArticleDOI
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung,Sally E. Wenzel,Jan Brozek,Andrew Bush,Mario Castro,Peter J. Sterk,Ian M. Adcock,Eric D. Bateman,Elisabeth H. Bel,Eugene R. Bleecker,Louis-Philippe Boulet,Christopher E. Brightling,Pascal Chanez,Sven-Erik Dahlén,Ratko Djukanovic,Urs Frey,Mina Gaga,Peter G. Gibson,Qutayba Hamid,Nizar N. Jajour,Thais Mauad,Ronald L. Sorkness,W. Gerald Teague +22 more
TL;DR: Recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults and coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy are provided.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
Journal ArticleDOI
Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program
Wendy C. Moore,Deborah A. Meyers,Sally E. Wenzel,W. Gerald Teague,Huashi Li,Xingnan Li,Ralph B. D'Agostino,Mario Castro,Douglas Curran-Everett,Anne M. Fitzpatrick,Benjamin Gaston,Nizar N. Jarjour,Ronald L. Sorkness,William J. Calhoun,Kian Fan Chung,Suzy A.A. Comhair,Raed A. Dweik,Elliot Israel,Stephen P. Peters,William W. Busse,Serpil C. Erzurum,Eugene R. Bleecker +21 more
TL;DR: Five distinct clinical phenotypes of asthma have been identified using an unsupervised hierarchical cluster analysis, which supports clinical heterogeneity in asthma and the need for new approaches for the classification of disease severity in asthma.
Journal ArticleDOI
Asthma outcomes: Biomarkers
Stanley J. Szefler,Sally E. Wenzel,Robert H. Brown,Serpil C. Erzurum,John V. Fahy,Robert G. Hamilton,John F. Hunt,Hirohito Kita,Andrew H. Liu,Reynold A. Panettieri,Robert P. Schleimer,Michael Minnicozzi +11 more
TL;DR: The working group participants propose the use of multiallergen screening in all asthma clinical trials to characterize study populations with respect to atopic status and develop standard procedures to harmonize sample collection for clinical trial biorepositories.
Journal ArticleDOI
Severe asthma: from characteristics to phenotypes to endotypes.
TL;DR: The identification of these endotypes, either by matching biology, genetics and therapeutic responses to therapy with clinically or statistically defined phenotypes or through unbiased genetic and genomic approaches, remains limited.
References
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Book
Applied Logistic Regression
David W. Hosmer,Stanley Lemeshow +1 more
TL;DR: Hosmer and Lemeshow as discussed by the authors provide an accessible introduction to the logistic regression model while incorporating advances of the last decade, including a variety of software packages for the analysis of data sets.
Journal ArticleDOI
Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.
Julie A. Anderson,Bartolome R. Celli,Gary T. Ferguson,Christine Jenkins,Paul W. Jones,Julie C. Yates,Jørgen Vestbo +6 more
TL;DR: The reduction in death from all causes among patients with COPD in the combination-therapy group did not reach the predetermined level of statistical significance, and there were significant benefits in all other outcomes among these patients.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
Automatic lung segmentation for accurate quantitation of volumetric X-ray CT images
TL;DR: A sequence of morphological operations is used to smooth the irregular boundary along the mediastinum in order to obtain results consistent with these obtained by manual analysis, in which only the most central pulmonary arteries are excluded from the lung region.
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