A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
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TLDR
Recent experimental findings are discussed that support the view that this 'neoHebbian' framework can account for memory behavior in a variety of learning situations.About:
This article is published in Trends in Neurosciences.The article was published on 2011-10-01 and is currently open access. It has received 377 citations till now. The article focuses on the topics: Hebbian theory & Long-term potentiation.read more
Citations
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How schema and novelty augment memory formation.
Marlieke T. R. van Kesteren,Marlieke T. R. van Kesteren,Dirk J. Ruiter,Guillén Fernández,Guillén Fernández,Richard N. Henson +5 more
TL;DR: Lesion and neuroimaging findings in animals and humans that relate to the apparent paradoxical relationship between schema and novelty and a framework relating key brain regions in medial temporal lobe and medial prefrontal cortex during encoding, consolidation and retrieval of information as a function of its congruency with existing information represented in neocortex are reviewed.
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The synaptic plasticity and memory hypothesis: encoding, storage and persistence.
TL;DR: Evidence derived using optical imaging, molecular-genetic and optogenetic techniques in conjunction with appropriate behavioural analyses continues to offer support for the idea that changing the strength of connections between neurons is one of the major mechanisms by which engrams are stored in the brain.
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What Learning Systems do Intelligent Agents Need? Complementary Learning Systems Theory Updated
TL;DR: This work updates complementary learning systems (CLS) theory and extends it by showing that recurrent activation of hippocampal traces can support some forms of generalization and that neocortical learning can be rapid for information that is consistent with known structure.
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States of Curiosity Modulate Hippocampus-Dependent Learning via the Dopaminergic Circuit
TL;DR: Findings suggest a link between the mechanisms supporting extrinsic reward motivation and intrinsic curiosity and highlight the importance of stimulating curiosity to create more effective learning experiences.
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High-frequency neural activity and human cognition: Past, present and possible future of intracranial EEG research
Jean-Philippe Lachaux,Nikolai Axmacher,Nikolai Axmacher,Florian Mormann,Eric Halgren,Nathan E. Crone +5 more
TL;DR: Overall, iEEG research on HFA should play an increasing role in cognitive neuroscience in humans, because it can be explicitly linked to basic research in animals, and the future evolution of this field is discussed.
References
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Dopamine-Dependent Interactions between Limbic and Prefrontal Cortical Plasticity in the Nucleus Accumbens: Disruption by Cocaine Sensitization
Yukiori Goto,Anthony A. Grace +1 more
TL;DR: Interactions of limbic-prefrontal cortical synaptic plasticity and its dysfunction within the accumbens could underlie complex information processing deficits observed in individuals following psychostimulant administration.
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Action Dominates Valence in Anticipatory Representations in the Human Striatum and Dopaminergic Midbrain
Marc Guitart-Masip,Lluís Fuentemilla,Dominik R. Bach,Quentin J. M. Huys,Peter Dayan,Raymond J. Dolan,Emrah Düzel +6 more
TL;DR: During anticipation, in the striatum and a lateral region within the substantia nigra/ventral tegmental area (SN/VTA), action representations dominated over valence representations, challenging a conventional and dominant association between these areas and state value representations.
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Protein synthesis-dependent formation of protein kinase mzeta in long-term potentiation
TL;DR: In this article, the authors examined the regulation of PKMzeta after sub-threshold stimulation that produced short-term potentiation (STP) and after suprathreshold stimulation by single and multiple tetanic trains that produced LTP.
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Dopamine Selectively Inhibits the Direct Cortical Pathway to the CA1 Hippocampal Region
TL;DR: The results provide the first evidence for strong dopaminergic control of transmission in the perforant path and suggest that dopamine hyperfunction and/or NMDA hypofunction abnormalities implicated in schizophrenia may isolate CA1 from its main source of sensory information.
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NOvelty-related motivation of anticipation and exploration by dopamine (NOMAD): implications for healthy aging.
TL;DR: It is proposed that maximizing the use of the dopaminergic neuromodulation mechanism by maintaining mobility and exploration of novel environments could be a potential mechanism to slow age-related decline of memory.
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