Journal ArticleDOI
A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation
TLDR
The effects, as a whole, depict this compound as a drug candidate for diseases in which peroxidative damage is associated with the induction of inflammatory responses and specifically with activation of a respiratory burst of leucocytes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1994-05-01. It has received 158 citations till now. The article focuses on the topics: Lipid peroxidation & Respiratory burst.read more
Citations
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Journal Article
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Journal ArticleDOI
Flavonoids as Antioxidants
TL;DR: This review presents the current knowledge on structural aspects and in vitro antioxidant capacity of most common flavonoids as well as in vivo antioxidant activity and effects on endogenous antioxidants.
Journal ArticleDOI
The biochemistry and medical significance of the flavonoids.
TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.
Journal ArticleDOI
Flavonoids: antioxidants or signalling molecules?
TL;DR: A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration.
Journal ArticleDOI
Antioxidant and prooxidant properties of flavonoids.
TL;DR: The aim of this review is to discuss both the antioxidant and prooxidant effects of flavonoids.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Book ChapterDOI
Flavonoids as antioxidants: determination of radical-scavenging efficiencies.
TL;DR: The radical chemistry of flavonoids not only is of interest from a kinetic or mechanistic point of view but also offers considerable insight into structural relationships of highly evolved plant components.
Journal ArticleDOI
Oxidants from phagocytes: agents of defense and destruction
TL;DR: From the Blood Research Laboratory and the Department of Medicine, Tufts-New England Medical Center.
Journal ArticleDOI
The O2- -forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function.
Journal ArticleDOI
Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages.
Catherine V. de Whalley,Sara M. Rankin,J.Robin S. Hoult,Wendy Jessup,Wendy Jessup,David S. Leake +5 more
TL;DR: It is shown that certain flavonoids, plant constituents found in the diet, are potent inhibitors of the modification of 125I-labelled LDL by macrophages, with IC50 values in the micromolar range, raising the possibility that flavonoid may protect LDL against oxidation in atherosclerotic lesions and may therefore be natural anti-atherosclerosis components of the diet.