A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis.
Louise China,Nick Freemantle,Ewan Forrest,Yiannis Kallis,Stephen D. Ryder,Gavin Wright,Andrew J. Portal,Natalia Becares Salles,Derek W. Gilroy,Alastair O’Brien +9 more
TLDR
In patients with decompensated cirrhosis, infection and increased systemic inflammation cause organ dysfunction and death in patients as discussed by the authors, and preclinical studies provide support for an anti-inflamma...Abstract:
Background Infection and increased systemic inflammation cause organ dysfunction and death in patients with decompensated cirrhosis. Preclinical studies provide support for an antiinflamma...read more
Citations
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Acute-on-Chronic Liver Failure Clinical Guidelines
Jasmohan S. Bajaj,Jacqueline G. O'Leary,Jennifer C. Lai,Florence Wong,Millie D. Long,Robert J. Wong,Patrick S. Kamath +6 more
TL;DR: These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and represent the official practice recommendations of the American College of Gastroenterology.
Journal ArticleDOI
Albumin in Advanced Liver Diseases: The Good and Bad of a Drug!
TL;DR: The role of albumin solutions in the treatment of decompensated cirrhosis was discussed in this article, where it was shown that long-term administration of HAS can modify the course of patients with liver failure by reducing the onset of new complications, improving the quality of life, and providing survival benefits.
Journal ArticleDOI
Gut-derived systemic inflammation as a driver of depression in chronic liver disease.
TL;DR: In this paper, the role of the dysfunctional gut-liver-brain axis as a driver of gut-derived systemic inflammation requires further exploration and consideration as a target for therapy for depression in patients with cirrhosis.
Journal ArticleDOI
Gut-derived systemic inflammation as a driver of depression in chronic liver disease
TL;DR: Ferrari et al. as mentioned in this paper investigated the role of the dysfunctional gut-liver-brain axis as a driver of gut-derived systemic inflammation in patients with depression and chronic liver disease.
Journal ArticleDOI
A randomized-controlled trial comparing 20% albumin to plasmalyte in patients with cirrhosis and sepsis-induced hypotension [ALPS trial].
Rakhi Maiwall,Abhinav Kumar,Samba Siva Rao Pasupuleti,A. Hidam,Harsh Vardhan Tevethia,Guresh Kumar,Amrish Sahney,Lalita Gouri Mitra,Shiv Kumar Sarin +8 more
TL;DR: In this paper , the authors compared the efficacy and safety of 20% albumin to plasmalyte in reversing sepsis-induced hypotension in critically ill patients with cirrhosis.
References
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Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis.
TL;DR: The stimulation of the renin‐angiotensin‐aldosterone system, vasopressin release and sympathetic nervous system associated with cirrhosis is not consonant with primary volume expansion, and favors the “overflow” hypothesis.
Journal ArticleDOI
Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis
Pau Sort,Miquel Navasa,Vicente Arroyo,Xavier Aldeguer,Ramon Planas,Luis Ruiz-del-Arbol,Lluis Castells,Victor Vargas,Germán Soriano,Mónica Guevara,Pere Ginès,Joan Rodés +11 more
TL;DR: In patients with cirrhosis and spontaneous bacterial peritonitis, treatment with intravenous albumin in addition to an antibiotic reduces the incidence of renal impairment and death in comparison with treatment with an antibiotic alone.
Journal ArticleDOI
Albumin Replacement in Patients with Severe Sepsis or Septic Shock
Pietro Caironi,Gianni Tognoni,Serge Masson,Roberto Fumagalli,Antonio Pesenti,Marilena Romero,Caterina Fanizza,Luisa Caspani,Stefano Faenza,Giacomo Grasselli,Gaetano Iapichino,Massimo Antonelli,Vieri Parrini,Gilberto Fiore,Roberto Latini,Luciano Gattinoni,Abstr Act +16 more
TL;DR: In patients with severe sepsis, albumin replacement in addition to crystalloids, as compared with crystalloids alone, did not improve the rate of survival at 28 and 90 days.
Journal ArticleDOI
Composite outcomes in randomized trials: greater precision but with greater uncertainty?
TL;DR: It is suggested that current guidelines for the undertaking and reporting of clinical trials could be revised to reflect the common use of composite outcomes in clinical trials, as well as the arguments for and against them.
Journal ArticleDOI
Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012
TL;DR: This version of the American Association for the Study of Liver Diseases Practice Guideline is the fourth iteration of this guideline and represents a thorough update of the 2009 version.
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