Journal ArticleDOI
A simple method to eliminate the antigenicity of surface class I MHC molecules from the membrane of viable cells by acid treatment at pH 3
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TLDR
A simple, reproducible method which specifically eliminates the antigenicity of surface class I major histocompatibility complex (MHC) molecules by acid treatment at pH 3 from the membrane of viable cells is described.About:
This article is published in Journal of Immunological Methods.The article was published on 1987-06-26. It has received 141 citations till now. The article focuses on the topics: Antigen & Antigenicity.read more
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Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability.
TL;DR: It is shown that the immunogenicity of HIV-1-derived peptides can be predicted more accurately by their dissociation rate than by the MHC class I binding affinity, which leads to a more precise identification of candidate CTL epitopes than selection based on affinity alone.
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Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells
Ignacio Cebrian,Geraldine Visentin,Nicolas Blanchard,Mabel Jouve,Alexandre Bobard,Catarina Moita,Jost Enninga,Luis F. Moita,Sebastian Amigorena,Ariel Savina +9 more
TL;DR: These findings provide insight into an intracellular traffic pathway required for crosspresentation and show that Sec22b-dependent recruitment of ER proteins to Phgs critically influences phagosomal functions in DCs.
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A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.
Eric Reits,Joost Neijssen,Carla A. Herberts,Willemien E. Benckhuijsen,Lennert Janssen,Jan W. Drijfhout,Jacques Neefjes +6 more
TL;DR: It is shown that intracellular aminopeptidases degrade peptides within seconds, almost irrespectively of amino acid sequence, and three distinct proteolytic activities during antigen processing in vivo are defined.
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Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia.
John W. Semple,John Freedman +1 more
TL;DR: Data indicate that CD4+ T-helper cells from patients with ATP are stimulated by normal platelet antigen(s) to secrete IL-2 and may modulate the enhanced antiplatelet autoantibody response.
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Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16‐induced tumors
Mariet C.W. Feltkamp,Gienke R. Vreugdenhil,Michel P. M. Vierboom,Elisabeth Ras,Sjoerd H. van der Burg,Jan ter Schegget,Cornelis J. M. Melief,W. Martin Kast +7 more
TL;DR: It is demonstrated that a CTL line raised against the subdominant CTL epitope, offered as synthetic peptide E7 49–57, eradicates established HPV16‐induced tumors in mice, and it is illustrated for the first time that HPV 16‐specific CTL interfere directly with HPV16-induced tumors.
References
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A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).
T. Abo,Charles M. Balch +1 more
TL;DR: The monoclonal antibody HNK-1, produced against a membrane antigen from the cultured T cell line, HSB-2, defines the first differentiation antigen shown to be selectively expressed on human NK and K cells.
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Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.
Hans-Gustaf Ljunggren,Klas Kärre +1 more
TL;DR: The reduced tumorigenicity of sublines with impaired H-2 expression is largely, if not exclusively due to rapid elimination by NK cells, which may reflect an inverse, indirect relation between factors controlling H- 2 expression and NK sensitivity.
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T cell subsets and the recognition of MHC class.
TL;DR: In this model T cell "recognition" of MHC and antigen consists of several independent but connected interactions of T cell surface structure with MHC molecules and antigen on antigen-presenting cells or targets.
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A glycolipid on the surface of mouse natural killer cells
TL;DR: Results indicate that asialo GM 1 is expressed on mouse NK cells in a high concentration, and suggests that the antibody to asIALo GM1 is responsible for the anti‐NK activity contained in the anti-BAT antiserum.
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Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection
TL;DR: H–2 gene transfection was used to restore expression of H–2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma and reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice.