Activation of p53 by Protein Inhibitor of Activated Stat1 (PIAS1)
TLDR
It is reported that protein inhibitor of activated Stat1 (PIAS1) interacts with the tetramerization and C-terminal regulatory domains of p53 in yeast two-hybrid analyses, suggesting that PIAS1 is a novel activator of p 53.About:
This article is published in Journal of Biological Chemistry.The article was published on 2002-03-08 and is currently open access. It has received 94 citations till now. The article focuses on the topics: Ectopic expression & SUMO protein.read more
Citations
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SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?
TL;DR: The small ubiquitin-related modifier SUMO posttranslationally modifies many proteins with roles in diverse processes including regulation of transcription, chromatin structure, and DNA repair, yielding new insights into regulation of gene expression, genome maintenance, and signal transduction.
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SIZ1-Mediated Sumoylation of ICE1 Controls CBF3/DREB1A Expression and Freezing Tolerance in Arabidopsis
Kenji Miura,Jing Bo Jin,Jiyoung Lee,Chan Yul Yoo,Vicki Stirm,Tomoko Miura,Edward N. Ashworth,Ray A. Bressan,Dae-Jin Yun,Paul M. Hasegawa +9 more
TL;DR: SIZ1-dependent sumoylation of ICE1 may activate and/or stabilize the protein, facilitating expression of CBF3/DREB1A and repression of MYB15, leading to low temperature tolerance.
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Nuclear and unclear functions of SUMO.
Jacob-S. Seeler,Anne Dejean +1 more
TL;DR: This work has shown that post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells.
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The genetics of the p53 pathway, apoptosis and cancer therapy
TL;DR: The p53 pathway has been shown to mediate cellular stress responses; p53 can initiate DNA repair, cell-cycle arrest, senescence and, importantly, apoptosis and this work focuses on how best to use knowledge of this pathway to tailor current therapies and develop novel ones.
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Coping with stress: multiple ways to activate p53
Henning F. Horn,Karen H. Vousden +1 more
TL;DR: This review will highlight some recently identified roles for p53 in tumour suppression, and discuss some of the numerous mechanisms through which p53 can be regulated and activated.
References
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p53, the Cellular Gatekeeper for Growth and Division
TL;DR: The author regrets the lack of citations for many important observations mentioned in the text, but their omission is made necessary by restrictions in the preparation of review manuscripts.
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Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
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Mdm2 promotes the rapid degradation of p53
TL;DR: It is proposed that the Mdm2-promoted degradation of p53 provides a new mechanism to ensure effective termination of the p53 signal.
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Regulation of p53 stability by Mdm2
TL;DR: It is shown that interaction with Mdm2 can also result in a large reduction in p53 protein levels through enhanced proteasome-dependent degradation, which may contribute to the maintenance of low p53 concentrations in normal cells.
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p53: puzzle and paradigm.
Linda J. Ko,Carol Prives +1 more
TL;DR: Some of the key developments leading to the current state of knowledge in p53 research are presented and how they either shed light on or add to the complexities of p53 are discussed.