Journal ArticleDOI
Allogeneic bone marrow–derived mesenchymal stromal cells for hepatitis B virus–related acute‐on‐chronic liver failure: A randomized controlled trial
Bing Liang Lin,Jun Feng Chen,Wei Hong Qiu,Ke Wei Wang,Dong ying Xie,Xiaoyong Chen,Qiu Li Liu,Liang Peng,Jian Guo Li,Yong Yu Mei,Wei Zhen Weng,Yan Wen Peng,Hui Juan Cao,Jun Qiang Xie,Shi Bin Xie,Andy Peng Xiang,Zhi Liang Gao,Zhi Liang Gao +17 more
TLDR
Peripheral infusion of allogeneic bone marrow–derived MSCs is safe and convenient for patients with HBV‐related ACLF and significantly increases the 24‐week survival rate by improving liver function and decreasing the incidence of severe infections.About:
This article is published in Hepatology.The article was published on 2017-07-01. It has received 191 citations till now. The article focuses on the topics: Liver function & Liver disease.read more
Citations
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Journal ArticleDOI
Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases.
TL;DR: Current understanding of the immunomodulatory mechanisms of MSCs and issues related to their therapeutic application are discussed, which suggest the plasticity of immunoregulation by M SCs is controlled by the intensity and complexity of inflammatory stimuli.
Journal ArticleDOI
Chronic hepatitis B virus infection.
TL;DR: Non-invasive assessment of liver fibrosis is emerging as an important assessment modality and long-term nucleos(t)ide-analogue therapy is safe and well tolerated, achieves potent viral suppression, and reduces the incidence of liver-related complications.
Journal ArticleDOI
Mesenchymal stem cell therapy for the treatment of inflammatory diseases: Challenges, opportunities, and future perspectives.
TL;DR: Recent progress made on the use of MSCs as immunomodulatory agents, developmental challenges posed by MSC-based therapy, and the strategies being used to overcome these challenges are discussed.
Journal ArticleDOI
Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
TL;DR: Not only are MSC-EVs’ preservation, transfer, and production easier, but their administration is also safer, hence some clinical trials are ongoing, however, much effort is required to improve the characterization of EVs to avoid artifacts and guarantee reproducibility of the studies.
Journal ArticleDOI
Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells as a Potential Source for Cartilage and Bone Regeneration: An In Vitro Study
Antonio Marmotti,Silvia Mattia,Filippo Castoldi,Andrea Barbero,Laura Mangiavini,D. E. Bonasia,Matteo Bruzzone,Federico Dettoni,Raffaele Scurati,Giuseppe M. Peretti +9 more
TL;DR: The results suggest that the UC-MSCs isolated from minced umbilical cords may represent a valuable allogeneic cell population, which might have a potential for orthopaedic tissue engineering such as the on-demand cell delivery using chondrogenic, osteogenic, and endochondral scaffold.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Mesenchymal stem cells reside in virtually all post-natal organs and tissues
TL;DR: The results suggest that the distribution of MSCs throughout the post-natal organism is related to their existence in a perivascular niche, which has implications for understanding MSC biology, and for clinical and pharmacological purposes.
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Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.
Guangwen Ren,Liying Zhang,Xin Zhao,Guangwu Xu,Yingyu Zhang,Arthur I. Roberts,Robert Chunhua Zhao,Yufang Shi +7 more
TL;DR: It is found that proinflammatory cytokines are required to induce immunosuppression by MSCs through the concerted action of chemokines and NO.
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Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
Raj Makkar,Rachel Ruckdeschel Smith,Ke Cheng,Konstantinos Malliaras,Louise Thomson,Daniel S. Berman,Lawrence S.C. Czer,Linda Marbán,Adam Mendizabal,Peter V. Johnston,Stuart D. Russell,Karl H. Schuleri,Albert C. Lardo,Gary Gerstenblith,Eduardo Marbán +14 more
TL;DR: In this paper, Cardiosphere-derived cells (CDCs) were used to reduce scarring after myocardial infarction, increase viable myocardium, and boost cardiac function in preclinical models.
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Human Bone Marrow Stromal Cells Express a Distinct Set of Biologically Functional Chemokine Receptors
Marek Honczarenko,Yi Le,Marcin Swierkowski,Ionita Ghiran,Aleksandra M. Glodek,Leslie E. Silberstein +5 more
TL;DR: The findings suggest that several chemokine axes may operate in BMSC biology and may be important parameters in the validation of cultured BMSCs intended for cell therapy.