American Society of Hematology 2020 guidelines for sickle cell disease: Prevention, diagnosis, and treatment of cerebrovascular disease in children and adults
Michael R. DeBaun,Lori C. Jordan,Allison A. King,Jeffrey Schatz,Elliott Vichinsky,Christine K. Fox,Robert C. McKinstry,Paul Telfer,Michael A. Kraut,Lubna Daraz,Fenella J. Kirkham,Fenella J. Kirkham,Fenella J. Kirkham,Mohammad Hassan Murad +13 more
TLDR
These evidence-based guidelines of the American Society of Hematology are intended to support the SCD community in decisions about prevention, diagnosis, and treatment of the most common neurological morbidities in SCD.About:
This article is published in Blood Advances.The article was published on 2020-04-28 and is currently open access. It has received 151 citations till now.read more
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Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France
F. Bernaudin,Jean-Hugues Dalle,Dominique Bories,Régis Peffault de Latour,Marie Robin,Yves Bertrand,Corinne Pondarré,Jean-Pierre Vannier,Bénédicte Neven,M. Kuentz,Sébastien Maury,Patrick Lutz,Catherine Paillard,Karima Yakouben,Isabelle Thuret,Claire Galambrun,Nathalie Dhedin,Charlotte Jubert,Pierre Rohrlich,Jacques-Olivier Bay,Felipe Suarez,Nicole Raus,Jean-Paul Vernant,Eliane Gluckman,Catherine Poirot,Gérard Socié,Société Française de Greffe de Moelle et de Thérapie Cellulaire +26 more
TL;DR: The aim of the present study was to analyze long-term outcomes, including chimerism, SCA-related events and biological data, and fertility in a French series of 234 SCA patients under 30 years of age who, from 1988 to 2012, received a matched-sibling-donor stem cell transplantation following standardized myeloablative conditioning.
Journal ArticleDOI
Voxelotor in adolescents and adults with sickle cell disease (HOPE): long-term follow-up results of an international, randomised, double-blind, placebo-controlled, phase 3 trial
Jo Howard,Kenneth I. Ataga,Robert Clark Brown,Maureen Achebe,Videlis Nduba,Amal El-Beshlawy,Hoda Hassab,Irene Agodoa,Margaret Tonda,Sarah Gray,Joshua Lehrer-Graiwer,Elliott Vichinsky +11 more
TL;DR: In 2019, voxelotor (1500 mg) was approved in the USA for the treatment of sickle cell disease in patients aged 12 years and older on the basis of HOPE trial data as mentioned in this paper.
Journal ArticleDOI
Moderate fixed‐dose hydroxyurea for primary prevention of strokes in Nigerian children with sickle cell disease: Final results of the SPIN trial
Najibah A. Galadanci,Shehu U. Abdullahi,Shehi Abubakar,Binta W. Jibir,Hauwa Aminu,Aliyu Tijjani,Muhammad S. Abba,Musa A. Tabari,Aisha Amal Galadanci,Awwal Musa Borodo,Raymond Belonwu,Auwal Salihu,Mark Rodeghier,Djamila L. Ghafuri,Brittany Covert Greene,Kathleen A. Neville,Adetola A. Kassim,Fenella J. Kirkham,Lori C. Jordan,Muktar H. Aliyu,Michael R. DeBaun +20 more
TL;DR: This is the first clinical safety and efficacy study of TruUCARTM GC027: The first-in-human, universal CAR-T therapy for adult relapsed/refractory T-cell acute lymphoblastic leukemia (r/r T-ALL) at the Virtual Annual Meeting I 2020.
Journal ArticleDOI
Hydroxyurea for primary stroke prevention in children with sickle cell anaemia in Nigeria (SPRING): a double-blind, multicentre, randomised, phase 3 trial.
Shehu U. Abdullahi,Binta W. Jibir,Halima Bello-Manga,Safiya Gambo,H. M. Inuwa,Aliyu Tijjani,Nura Idris,Aisha Amal Galadanci,Mustapha Shuaibu Hikima,Najibah A. Galadanci,Awwal Musa Borodo,AM Tabari,Lawal Haliru,A. Suleiman,Jamil Ibrahim,Brittany Covert Greene,Djamila L. Ghafuri,Mark Rodeghier,James C. Slaughter,Fenella J. Kirkham,Kathleen A. Neville,Adetola A. Kassim,Edwin Trevathan,Lori C. Jordan,Muktar H. Aliyu,Michael Dean +25 more
TL;DR: The SPRING trial as mentioned in this paper showed that the initial moderate-dose compared with low-dose hydroxyurea decreases the incidence of stroke for children with abnormal transcranial Doppler velocities.
Journal ArticleDOI
Red cell transfusion and alloimmunization in sickle cell disease
Grace Linder,Stella T. Chou +1 more
TL;DR: In this paper, the authors discuss transfusion methods, indications, and complications in sickle cell disease with an emphasis on alloimmunization and delayed hemolytic transfusion reactions.
References
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GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
TL;DR: The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.
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Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more
TL;DR: These guidelines supersede the prior 2007 guidelines and 2009 updates and support the overarching concept of stroke systems of care and detail aspects of stroke care from patient recognition; emergency medical services activation, transport, and triage; through the initial hours in the emergency department and stroke unit.
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GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables
Gordon H. Guyatt,Andrew D Oxman,Elie A. Akl,Regina Kunz,Gunn Elisabeth Vist,Jan Brozek,Susan L Norris,Yngve Falck-Ytter,Paul Glasziou,Hans deBeer,Roman Jaeschke,David Rind,Joerg J Meerpohl,Philipp Dahm,Holger J. Schünemann +14 more
TL;DR: The GRADE process begins with asking an explicit question, including specification of all important outcomes, and provides explicit criteria for rating the quality of evidence that include study design, risk of bias, imprecision, inconsistency, indirectness, and magnitude of effect.
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Validation of Clinical Classification Schemes for Predicting Stroke: Results From the National Registry of Atrial Fibrillation
Brian F. Gage,Amy D. Waterman,William D. Shannon,Michael Boechler,Michael W. Rich,Martha J. Radford +5 more
TL;DR: The 2 existing classification schemes and especially a new stroke risk index, CHADS, can quantify risk of stroke for patients who have AF and may aid in selection of antithrombotic therapy.
Journal ArticleDOI
Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
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