Journal ArticleDOI
Amino-decorated mesoporous silica nanoparticles for controlled sofosbuvir delivery
Yasir Mehmood,Ikram Ullah Khan,Yasser Shahzad,Rizwan Ullah Khan,Syed Haroon Khalid,Abid Mehmood Yousaf,Talib Hussain,Sajid Asghar,Ikrima Khalid,Muhammad Asif,Shefaat Ullah Shah +10 more
TLDR
In this article, the synthesis of amino-decorated mesoporous silica nanoparticles (MSNs) for sustained delivery and enhanced bioavailability of sofosbuvir was described.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2020-02-15. It has received 25 citations till now.read more
Citations
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Journal ArticleDOI
Mesoporous silica nanoparticles: synthesis methods and their therapeutic use-recent advances.
Mohsen Ghaferi,Maedeh Koohi Moftakhari Esfahani,Aun Raza,Sitah Al Harthi,Sitah Al Harthi,Hasan Ebrahimi Shahmabadi,Seyed Ebrahim Alavi +6 more
TL;DR: A literature review will take an in-depth look into the properties of various types of Mesoporous silica nanoparticles, and discuss their characteristics, in terms of cellular uptake, drug delivery and release, and their therapeutic applications, biocompatibility and safety issues.
Journal ArticleDOI
Understanding the removal of an anionic dye in textile wastewaters by adsorption on ZnCl2 activated carbons from rice and coffee husk wastes: A combined experimental and theoretical study
Marcela Paredes-Laverde,Maurin Salamanca,Javier D. Diaz-Corrales,Elizabeth Flórez,Javier Silva-Agredo,Ricardo A. Torres-Palma +5 more
TL;DR: In this article, the removal efficiency of the obtained adsorbents was tested using indigo carmine (IC) at different pH, as a model dye, in both distilled water and textile wastewater.
Journal ArticleDOI
Recent advances in prodrug-based nanoparticle therapeutics
TL;DR: In this paper, an overview of FDA-approved prodrugs is provided to familiarize the reader with their advantages over traditional small molecule drugs and to describe the chemistries that can be used to create them.
Journal ArticleDOI
Mesoporous Silica Nanoparticles Improve Oral Delivery of Antitubercular Bicyclic Nitroimidazoles.
Chee Wei Ang,Chee Wei Ang,Lendl Tan,Zhi Qu,Nicholas P. West,Mark E. Cooper,Amirali Popat,Mark A. T. Blaskovich +7 more
TL;DR: In this paper, mesoporous silica nanoparticles (MCM-41) were used as drug carriers for the delivery of poorly soluble antibacterial agents against tuberculosis in mice.
Journal ArticleDOI
Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
Nagi M. El-Shafai,Mamdouh S. Masoud,Mohamed Ibrahim,Mohamed S. Ramadan,Gaber A.M. Mersal,Ibrahim M. El-Mehasseb +5 more
TL;DR: In this article , the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to create a novel hybrid composite (Cs@βCD -SOF).
References
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Adsorption of Gases in Multimolecular Layers
Journal ArticleDOI
The Determination of Pore Volume and Area Distributions in Porous Substances. I. Computations from Nitrogen Isotherms
Journal ArticleDOI
Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
Journal ArticleDOI
Sofosbuvir for previously untreated chronic hepatitis C infection
Eric Lawitz,Alessandra Mangia,David L. Wyles,Maribel Rodriguez-Torres,Tarek Hassanein,Stuart C. Gordon,Michael Schultz,M. Davis,Zeid Kayali,K. Rajender Reddy,Ira M. Jacobson,Kris V. Kowdley,L. Nyberg,G. Mani Subramanian,Robert H. Hyland,Sarah Arterburn,Deyuan Jiang,John McNally,Diana M. Brainard,William T. Symonds,John G. McHutchison,Aasim Sheikh,Zobair M. Younossi,Edward Gane +23 more
TL;DR: In a single-group study of sofosbuvir combined with peginterferon-ribavirin, patients with predominantly genotype 1 or 4 HCV infection had a rate of sustained virologic response of 90% at 12 weeks.
Journal ArticleDOI
Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs.
TL;DR: In this review, it is intended to discuss the recent advances related on the area of solid dispersions.
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Chitosan-Capped Mesoporous Silica Nanoparticles as pH-Responsive Nanocarriers for Controlled Drug Release
Xiaoxi Hu,Yun Wang,Bo Peng +2 more